5M2V

Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 7E5 A 301

Chain	Residue
A	TYR61
A	GLU190
A	SER193
A	PRO88
A	LEU89
A	THR90
A	ARG95
A	SER141
A	THR142
A	SER173
A	MET189

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 302

Chain	Residue
A	HIS244
A	LYS247

---

site_id	AC3
Number of Residues	1
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG31

---

site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 A 304

Chain	Residue
A	SER22

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 305

Chain	Residue
A	GLN238
B	SER213

---

site_id	AC6
Number of Residues	11
Details	binding site for residue 7E5 B 301

Chain	Residue
B	GLU13
B	TYR61
B	PRO88
B	LEU89
B	THR90
B	ARG95
B	SER141
B	THR142
B	MET189
B	GLU190
B	SER193

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 B 302

Chain	Residue
B	HIS244
B	LYS247

---

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 B 303

Chain	Residue
A	GLU133
B	ARG31

---

site_id	AC9
Number of Residues	1
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG227

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CL B 305

Chain	Residue
B	GLN238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ

Chain	Residue	Details
A	LYS103
A	PHE105
A	LYS156
A	MET157
B	LYS103
B	PHE105
B	LYS156
B	MET157

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ

Chain	Residue	Details
A	ILE110
A	THR205
B	ILE110
B	THR205

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000255

Chain	Residue	Details
A	ILE177
B	ILE177

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000255

Chain	Residue	Details
A	SER213
B	SER213

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ILE11
A	MET18
A	VAL218
B	ILE11
B	MET18
B	VAL218

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