5LRW
Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ALA342 |
| A | SER343 |
| A | HOH631 |
| A | HOH690 |
| A | HOH711 |
| C | GLU145 |
| C | ASP146 |
| C | SER149 |
| C | ARG153 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | GLN136 |
| C | LEU137 |
| C | PRO138 |
| C | ARG308 |
| C | HOH619 |
| C | HOH624 |
| C | HOH651 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide CYS C 194 and NEH D 76 |
| Chain | Residue |
| C | THR188 |
| C | THR189 |
| C | ASP191 |
| C | GLY192 |
| C | ASN193 |
| C | LEU195 |
| C | LEU196 |
| C | HIS197 |
| C | ALA198 |
| C | SER293 |
| C | ALA357 |
| C | PHE359 |
| C | HOH715 |
| D | GLY75 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide GLY D 75 and NEH D 76 |
| Chain | Residue |
| C | ASP191 |
| C | GLY192 |
| C | CYS194 |
| C | SER293 |
| C | LEU294 |
| C | ALA357 |
| C | PHE359 |
| C | HOH611 |
| D | ARG74 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Region: {"description":"Regulatory loop","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12682062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14748687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22179831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Stabilizes the conformation of the regulatory loop","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
