5LOW

Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
B	0016020	cellular_component	membrane
C	0016020	cellular_component	membrane
D	0000149	molecular_function	SNARE binding
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0017075	molecular_function	syntaxin-1 binding
F	0000149	molecular_function	SNARE binding
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0017075	molecular_function	syntaxin-1 binding
H	0016020	cellular_component	membrane
I	0016020	cellular_component	membrane
J	0016020	cellular_component	membrane
K	0000149	molecular_function	SNARE binding
K	0005249	molecular_function	voltage-gated potassium channel activity
K	0017075	molecular_function	syntaxin-1 binding
M	0000149	molecular_function	SNARE binding
M	0005249	molecular_function	voltage-gated potassium channel activity
M	0017075	molecular_function	syntaxin-1 binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue GOL A 701

Chain	Residue
A	GLN554
A	GLU610
K	GLN20

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 702

Chain	Residue
A	ASP571
A	ASP577
A	ASP631
A	TYR632
A	ASP633

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 703

Chain	Residue
A	ASP571
A	ASP631
A	ASP633
A	ASP639
A	MET570

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL B 701

Chain	Residue
B	LYS616
H	LEU545
H	GLU670

---

site_id	AC5
Number of Residues	7
Details	binding site for residue CA B 702

Chain	Residue
B	MET570
B	ASP571
B	ASP631
B	ASP633
B	ASP639
B	CA703
B	HOH806

---

site_id	AC6
Number of Residues	7
Details	binding site for residue CA B 703

Chain	Residue
B	ASP571
B	ASP577
B	ASP631
B	TYR632
B	ASP633
B	CA702
J	HOH804

---

site_id	AC7
Number of Residues	1
Details	binding site for residue GOL C 701

Chain	Residue
C	TRP672

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA C 702

Chain	Residue
C	MET570
C	ASP571
C	ASP631
C	ASP633
C	ASP639
C	HOH806

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA C 703

Chain	Residue
C	ASP571
C	ASP577
C	ASP631
C	TYR632
C	ASP633
C	HOH805

---

site_id	AD1
Number of Residues	6
Details	binding site for residue CA H 701

Chain	Residue
H	ASP571
H	ASP577
H	ASP631
H	TYR632
H	ASP633
H	HOH802

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CA H 702

Chain	Residue
G	HOH301
H	MET570
H	ASP633
H	ASP639
H	HOH803

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA I 701

Chain	Residue
C	ASP614
I	ASP571
I	ASP577
I	ASP631
I	TYR632
I	ASP633

---

site_id	AD4
Number of Residues	5
Details	binding site for residue CA I 702

Chain	Residue
I	MET570
I	ASP571
I	ASP631
I	ASP633
I	ASP639

---

site_id	AD5
Number of Residues	5
Details	binding site for residue CA J 701

Chain	Residue
J	MET570
J	ASP571
J	ASP633
J	ASP639
J	HOH809

---

site_id	AD6
Number of Residues	5
Details	binding site for residue CA J 702

Chain	Residue
J	ASP571
J	ASP577
J	ASP631
J	TYR632
J	ASP633

---

site_id	AD7
Number of Residues	2
Details	binding site for residue GOL K 101

Chain	Residue
H	HIS617
K	ARG59

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL M 101

Chain	Residue
C	GLY635
M	ASP19
M	ASP23
N	GLU143

---

site_id	AD9
Number of Residues	3
Details	binding site for residue GOL N 301

Chain	Residue
N	THR190
N	ASP193
N	GLN197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	798
Details	Domain: {"description":"C2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17166855","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CM6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17166855","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CM5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	124
Details	Domain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---