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5LGD

The CIDRa domain from MCvar1 PfEMP1 bound to CD36

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000165biological_processMAPK cascade
A0001540molecular_functionamyloid-beta binding
A0001954biological_processpositive regulation of cell-matrix adhesion
A0002532biological_processproduction of molecular mediator involved in inflammatory response
A0005041molecular_functionlow-density lipoprotein particle receptor activity
A0005044molecular_functionscavenger receptor activity
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006869biological_processlipid transport
A0006898biological_processreceptor-mediated endocytosis
A0006910biological_processphagocytosis, recognition
A0006911biological_processphagocytosis, engulfment
A0007155biological_processcell adhesion
A0007166biological_processcell surface receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007596biological_processblood coagulation
A0008035molecular_functionhigh-density lipoprotein particle binding
A0008289molecular_functionlipid binding
A0009617biological_processresponse to bacterium
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0010886biological_processpositive regulation of cholesterol storage
A0015636molecular_functionshort-chain fatty acid transmembrane transporter activity
A0015908biological_processfatty acid transport
A0015909biological_processlong-chain fatty acid transport
A0015911biological_processlong-chain fatty acid import across plasma membrane
A0015912biological_processshort-chain fatty acid transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016525biological_processnegative regulation of angiogenesis
A0019915biological_processlipid storage
A0019934biological_processcGMP-mediated signaling
A0030169molecular_functionlow-density lipoprotein particle binding
A0030194biological_processpositive regulation of blood coagulation
A0030299biological_processintestinal cholesterol absorption
A0030301biological_processcholesterol transport
A0030666cellular_componentendocytic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031526cellular_componentbrush border membrane
A0031623biological_processreceptor internalization
A0031664biological_processregulation of lipopolysaccharide-mediated signaling pathway
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0033993biological_processresponse to lipid
A0034121biological_processregulation of toll-like receptor signaling pathway
A0034197biological_processtriglyceride transport
A0034381biological_processplasma lipoprotein particle clearance
A0034383biological_processlow-density lipoprotein particle clearance
A0034599biological_processcellular response to oxidative stress
A0035325molecular_functionToll-like receptor binding
A0035579cellular_componentspecific granule membrane
A0035634biological_processresponse to stilbenoid
A0038024molecular_functioncargo receptor activity
A0038060biological_processnitric oxide-cGMP-mediated signaling
A0042308biological_processnegative regulation of protein import into nucleus
A0042953biological_processlipoprotein transport
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043235cellular_componentreceptor complex
A0043254biological_processregulation of protein-containing complex assembly
A0043277biological_processapoptotic cell clearance
A0043410biological_processpositive regulation of MAPK cascade
A0044539biological_processlong-chain fatty acid import into cell
A0044877molecular_functionprotein-containing complex binding
A0045121cellular_componentmembrane raft
A0045177cellular_componentapical part of cell
A0045335cellular_componentphagocytic vesicle
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0050431molecular_functiontransforming growth factor beta binding
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050830biological_processdefense response to Gram-positive bacterium
A0050892biological_processintestinal absorption
A0050909biological_processsensory perception of taste
A0055096biological_processlow-density lipoprotein particle mediated signaling
A0060100biological_processpositive regulation of phagocytosis, engulfment
A0060907biological_processpositive regulation of macrophage cytokine production
A0070053molecular_functionthrombospondin receptor activity
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070508biological_processcholesterol import
A0070542biological_processresponse to fatty acid
A0070543biological_processresponse to linoleic acid
A0070892molecular_functionlipoteichoic acid immune receptor activity
A0071221biological_processcellular response to bacterial lipopeptide
A0071222biological_processcellular response to lipopolysaccharide
A0071223biological_processcellular response to lipoteichoic acid
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071447biological_processcellular response to hydroperoxide
A0071726biological_processcellular response to diacyl bacterial lipopeptide
A0071813molecular_functionlipoprotein particle binding
A0071944cellular_componentcell periphery
A0097009biological_processenergy homeostasis
A0098900biological_processregulation of action potential
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140052biological_processcellular response to oxidised low-density lipoprotein particle stimulus
A0150024biological_processoxidised low-density lipoprotein particle clearance
A0150025molecular_functionoxidised low-density lipoprotein particle receptor activity
A0150094biological_processamyloid-beta clearance by cellular catabolic process
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1901480molecular_functionoleate transmembrane transporter activity
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1904646biological_processcellular response to amyloid-beta
A1990000biological_processamyloid fibril formation
A1990379biological_processlipid transport across blood-brain barrier
A2000121biological_processregulation of removal of superoxide radicals
A2000334biological_processpositive regulation of blood microparticle formation
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues15
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AGLY2-CYS7
ASER462-LYS472

site_idSWS_FT_FI2
Number of Residues42
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLY8-VAL29
ALEU440-ILE461

site_idSWS_FT_FI3
Number of Residues409
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLY30-ASN439

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Critical for TLR4-TLR6 dimerization and signaling => ECO:0000269|PubMed:20037584
ChainResidueDetails
ATYR463

site_idSWS_FT_FI5
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:8798390
ChainResidueDetails
ACYS3
ACYS7
ACYS464
ACYS466

site_idSWS_FT_FI6
Number of Residues7
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN79
AASN102
AASN134
AASN163
AASN220
AASN235
AASN247

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN205

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401
ChainResidueDetails
AASN321

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN417

site_idSWS_FT_FI10
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:18353783, ECO:0000305|PubMed:21610069
ChainResidueDetails
ALYS469
ALYS472

226707

PDB entries from 2024-10-30

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