5LG3

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with chlorpromazine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042391	biological_process	regulation of membrane potential
F	0042802	molecular_function	identical protein binding
F	0043005	cellular_component	neuron projection
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042391	biological_process	regulation of membrane potential
G	0042802	molecular_function	identical protein binding
G	0043005	cellular_component	neuron projection
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042391	biological_process	regulation of membrane potential
H	0042802	molecular_function	identical protein binding
H	0043005	cellular_component	neuron projection
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0007165	biological_process	signal transduction
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0042391	biological_process	regulation of membrane potential
I	0042802	molecular_function	identical protein binding
I	0043005	cellular_component	neuron projection
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0042391	biological_process	regulation of membrane potential
J	0042802	molecular_function	identical protein binding
J	0043005	cellular_component	neuron projection

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue Z80 A 401

Chain	Residue
A	ILE20
A	ILE162
A	ILE23
A	PHE126
A	VAL147
A	THR149
A	ASN151
A	GLU155
A	ASP158
A	TRP160

---

site_id	AC2
Number of Residues	11
Details	binding site for residue Z80 B 401

Chain	Residue
B	ILE20
B	ASN21
B	ILE23
B	PHE126
B	VAL147
B	THR149
B	ASN151
B	GLU155
B	ASP158
B	TRP160
B	ILE162

---

site_id	AC3
Number of Residues	12
Details	binding site for residue Z80 C 401

Chain	Residue
C	ILE20
C	ASN21
C	ILE23
C	PHE126
C	VAL147
C	THR149
C	GLU150
C	ASN151
C	GLU155
C	ASP158
C	TRP160
C	ILE162

---

site_id	AC4
Number of Residues	10
Details	binding site for residue Z80 D 401

Chain	Residue
D	ASN21
D	ILE23
D	PHE126
D	VAL147
D	THR149
D	ASN151
D	GLU155
D	ASP158
D	TRP160
D	ILE162

---

site_id	AC5
Number of Residues	12
Details	binding site for residue Z80 E 401

Chain	Residue
E	ILE20
E	ASN21
E	ILE23
E	PHE126
E	VAL147
E	THR149
E	GLU150
E	ASN151
E	GLU155
E	ASP158
E	TRP160
E	ILE162

---

site_id	AC6
Number of Residues	10
Details	binding site for residue Z80 F 401

Chain	Residue
F	ILE20
F	ILE23
F	PHE126
F	VAL147
F	THR149
F	ASN151
F	GLU155
F	ASP158
F	TRP160
F	ILE162

---

site_id	AC7
Number of Residues	12
Details	binding site for residue Z80 G 401

Chain	Residue
G	ILE20
G	ASN21
G	ILE23
G	PHE126
G	VAL147
G	THR149
G	GLU150
G	ASN151
G	GLU155
G	ASP158
G	TRP160
G	ILE162

---

site_id	AC8
Number of Residues	10
Details	binding site for residue Z80 H 401

Chain	Residue
H	ILE20
H	ILE23
H	PHE126
H	VAL147
H	THR149
H	ASN151
H	GLU155
H	ASP158
H	TRP160
H	ILE162

---

site_id	AC9
Number of Residues	11
Details	binding site for residue Z80 I 401

Chain	Residue
I	ASN21
I	ILE23
I	PHE126
I	VAL147
I	THR149
I	GLU150
I	ASN151
I	GLU155
I	ASP158
I	TRP160
I	ILE162

---

site_id	AD1
Number of Residues	11
Details	binding site for residue Z80 J 401

Chain	Residue
J	ILE23
J	PHE126
J	VAL147
J	THR149
J	GLU150
J	ASN151
J	GLU155
J	ASP158
J	TRP160
J	ILE162
J	ILE20

---