5LD2

Cryo-EM structure of RecBCD+DNA complex revealing activated nuclease domain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000725	biological_process	recombinational repair
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0004518	molecular_function	nuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0006974	biological_process	DNA damage response
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0008854	molecular_function	exodeoxyribonuclease V activity
B	0009314	biological_process	response to radiation
B	0009338	cellular_component	exodeoxyribonuclease V complex
B	0015616	molecular_function	DNA translocase activity
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0043138	molecular_function	3'-5' DNA helicase activity
B	0044355	biological_process	clearance of foreign intracellular DNA
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000725	biological_process	recombinational repair
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0004386	molecular_function	helicase activity
C	0004518	molecular_function	nuclease activity
C	0004527	molecular_function	exonuclease activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0008854	molecular_function	exodeoxyribonuclease V activity
C	0009314	biological_process	response to radiation
C	0009338	cellular_component	exodeoxyribonuclease V complex
C	0016787	molecular_function	hydrolase activity
C	0044355	biological_process	clearance of foreign intracellular DNA
C	0140097	molecular_function	catalytic activity, acting on DNA
D	0000166	molecular_function	nucleotide binding
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000725	biological_process	recombinational repair
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0004386	molecular_function	helicase activity
D	0004518	molecular_function	nuclease activity
D	0004527	molecular_function	exonuclease activity
D	0005524	molecular_function	ATP binding
D	0006281	biological_process	DNA repair
D	0006302	biological_process	double-strand break repair
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0008854	molecular_function	exodeoxyribonuclease V activity
D	0009338	cellular_component	exodeoxyribonuclease V complex
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0043139	molecular_function	5'-3' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ANP B 1501

Chain	Residue
B	GLY26
B	ARG448
B	LYS483
B	GLY746
B	GLU748
B	ARG808
B	MG1502
B	THR27
B	GLY28
B	LYS29
B	THR30
B	PHE31
B	GLU385
B	GLN417
B	TRP447

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG B 1502

Chain	Residue
B	THR30
B	GLU385
B	ANP1501

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	266
Details	Domain: {"description":"UvrD-like helicase C-terminal","evidences":[{"source":"HAMAP-Rule","id":"MF_01485","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	DNA binding: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01485","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15538360","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15538360","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01485","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15538360","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18668125","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01487","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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