5LA4
Crystal structure of apo human proheparanase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004566 | molecular_function | beta-glucuronidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006029 | biological_process | proteoglycan metabolic process |
| A | 0007155 | biological_process | cell adhesion |
| A | 0007160 | biological_process | cell-matrix adhesion |
| A | 0010575 | biological_process | positive regulation of vascular endothelial growth factor production |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030194 | biological_process | positive regulation of blood coagulation |
| A | 0030200 | biological_process | heparan sulfate proteoglycan catabolic process |
| A | 0030202 | biological_process | heparin proteoglycan metabolic process |
| A | 0030305 | molecular_function | heparanase activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0033690 | biological_process | positive regulation of osteoblast proliferation |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042060 | biological_process | wound healing |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045545 | molecular_function | syndecan binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051797 | biological_process | regulation of hair follicle development |
| A | 0051798 | biological_process | positive regulation of hair follicle development |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0060055 | biological_process | angiogenesis involved in wound healing |
| A | 0061028 | biological_process | establishment of endothelial barrier |
| A | 0061042 | biological_process | vascular wound healing |
| A | 0071806 | biological_process | protein transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 47 |
| Details | Propeptide: {"description":"Linker peptide","featureId":"PRO_0000042261","evidences":[{"source":"PubMed","id":"10395326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10446189","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12713442","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 129 |
| Details | Region: {"description":"Required for heterodimerization with the heparanase 8 kDa subunit","evidences":[{"source":"PubMed","id":"12927802","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Region: {"description":"Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15760902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15760902","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14573609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28581485","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5E8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5E9C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
