5L8H
Structure of USP46-UbVME
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001662 | biological_process | behavioral fear response |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0008343 | biological_process | adult feeding behavior |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0032228 | biological_process | regulation of synaptic transmission, GABAergic |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048149 | biological_process | behavioral response to ethanol |
| A | 0060013 | biological_process | righting reflex |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099149 | biological_process | regulation of postsynaptic neurotransmitter receptor internalization |
| A | 0101005 | molecular_function | deubiquitinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1000 |
| Chain | Residue |
| A | CYS182 |
| A | CYS185 |
| A | CYS229 |
| A | CYS232 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYVNSvLQ |
| Chain | Residue | Details |
| A | GLY36-GLN51 |
| site_id | PS00973 |
| Number of Residues | 19 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY |
| Chain | Residue | Details |
| A | TYR296-TYR314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26388029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22043315","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5CVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L8H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
