5L46
Crystal structure of human dimethylglycine-dehydrogenase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006579 | biological_process | amino-acid betaine catabolic process |
A | 0009055 | molecular_function | electron transfer activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019695 | biological_process | choline metabolic process |
A | 0042426 | biological_process | choline catabolic process |
A | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
B | 0003723 | molecular_function | RNA binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006579 | biological_process | amino-acid betaine catabolic process |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019695 | biological_process | choline metabolic process |
B | 0042426 | biological_process | choline catabolic process |
B | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | binding site for residue FAD A 901 |
Chain | Residue |
A | ILE55 |
A | GLY87 |
A | SER88 |
A | THR89 |
A | HIS91 |
A | ALA93 |
A | LEU95 |
A | PRO218 |
A | VAL219 |
A | ALA247 |
A | ALA248 |
A | GLY56 |
A | GLY249 |
A | TRP251 |
A | VAL255 |
A | HIS270 |
A | TYR272 |
A | GLY370 |
A | PRO371 |
A | ILE372 |
A | PHE397 |
A | GLY398 |
A | GLY57 |
A | TYR399 |
A | GLY400 |
A | ILE401 |
A | ILE402 |
A | GLY58 |
A | CYS59 |
A | VAL60 |
A | LEU79 |
A | GLU80 |
A | LYS81 |
site_id | AC2 |
Number of Residues | 31 |
Details | binding site for Di-peptide FAD B 901 and HIS B 64 |
Chain | Residue |
B | ILE55 |
B | GLY56 |
B | GLY57 |
B | GLY58 |
B | CYS59 |
B | VAL60 |
B | LEU79 |
B | GLU80 |
B | LYS81 |
B | GLY87 |
B | SER88 |
B | THR89 |
B | TRP90 |
B | ALA92 |
B | ALA93 |
B | GLY94 |
B | LEU95 |
B | VAL219 |
B | ALA248 |
B | GLY249 |
B | TRP251 |
B | HIS270 |
B | TYR272 |
B | VAL368 |
B | PRO371 |
B | ILE372 |
B | PHE397 |
B | TYR399 |
B | GLY400 |
B | ILE401 |
B | ILE402 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27486859, ECO:0007744|PDB:5L46 |
Chain | Residue | Details |
A | CYS59 | |
B | PHE397 | |
A | GLU80 | |
A | GLY87 | |
A | VAL219 | |
A | PHE397 | |
B | CYS59 | |
B | GLU80 | |
B | GLY87 | |
B | VAL219 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q63342 |
Chain | Residue | Details |
A | TRP251 | |
B | TYR744 | |
A | GLU580 | |
A | TYR676 | |
A | GLU683 | |
A | TYR744 | |
B | TRP251 | |
B | GLU580 | |
B | TYR676 | |
B | GLU683 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Tele-8alpha-FAD histidine => ECO:0000269|PubMed:27486859, ECO:0007744|PDB:5L46 |
Chain | Residue | Details |
A | HIS91 | |
B | HIS91 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS114 | |
B | LYS335 | |
B | LYS360 | |
B | LYS764 | |
A | LYS168 | |
A | LYS223 | |
A | LYS335 | |
A | LYS360 | |
A | LYS764 | |
B | LYS114 | |
B | LYS168 | |
B | LYS223 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS148 | |
A | LYS434 | |
A | LYS523 | |
A | LYS655 | |
B | LYS148 | |
B | LYS434 | |
B | LYS523 | |
B | LYS655 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DBT9 |
Chain | Residue | Details |
A | LYS317 | |
A | LYS319 | |
A | LYS795 | |
B | LYS317 | |
B | LYS319 | |
B | LYS795 |