5L46
Crystal structure of human dimethylglycine-dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006579 | biological_process | amino-acid betaine catabolic process |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019695 | biological_process | choline metabolic process |
| A | 0042426 | biological_process | choline catabolic process |
| A | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006579 | biological_process | amino-acid betaine catabolic process |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019695 | biological_process | choline metabolic process |
| B | 0042426 | biological_process | choline catabolic process |
| B | 0047865 | molecular_function | dimethylglycine dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue FAD A 901 |
| Chain | Residue |
| A | ILE55 |
| A | GLY87 |
| A | SER88 |
| A | THR89 |
| A | HIS91 |
| A | ALA93 |
| A | LEU95 |
| A | PRO218 |
| A | VAL219 |
| A | ALA247 |
| A | ALA248 |
| A | GLY56 |
| A | GLY249 |
| A | TRP251 |
| A | VAL255 |
| A | HIS270 |
| A | TYR272 |
| A | GLY370 |
| A | PRO371 |
| A | ILE372 |
| A | PHE397 |
| A | GLY398 |
| A | GLY57 |
| A | TYR399 |
| A | GLY400 |
| A | ILE401 |
| A | ILE402 |
| A | GLY58 |
| A | CYS59 |
| A | VAL60 |
| A | LEU79 |
| A | GLU80 |
| A | LYS81 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | binding site for Di-peptide FAD B 901 and HIS B 64 |
| Chain | Residue |
| B | ILE55 |
| B | GLY56 |
| B | GLY57 |
| B | GLY58 |
| B | CYS59 |
| B | VAL60 |
| B | LEU79 |
| B | GLU80 |
| B | LYS81 |
| B | GLY87 |
| B | SER88 |
| B | THR89 |
| B | TRP90 |
| B | ALA92 |
| B | ALA93 |
| B | GLY94 |
| B | LEU95 |
| B | VAL219 |
| B | ALA248 |
| B | GLY249 |
| B | TRP251 |
| B | HIS270 |
| B | TYR272 |
| B | VAL368 |
| B | PRO371 |
| B | ILE372 |
| B | PHE397 |
| B | TYR399 |
| B | GLY400 |
| B | ILE401 |
| B | ILE402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27486859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L46","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q63342","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Tele-8alpha-FAD histidine","evidences":[{"source":"PubMed","id":"27486859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L46","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBT9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
