5L03

Crystal structure of 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE Synthase from BURKHOLDERIA PSEUDOMALLEI bound to L-tryptophan hydroxamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0046872	molecular_function	metal ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	ASP10
A	HIS12
A	HIS44
A	6ZB202

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site_id	AC2
Number of Residues	15
Details	binding site for residue 6ZB A 202

Chain	Residue
A	GLY60
A	PHE63
A	ASP65
A	LEU78
A	ZN201
A	HOH302
A	HOH303
A	HOH313
A	HOH385
B	LYS134
A	ASP10
A	HIS12
A	SER37
A	HIS44
A	ILE59

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 201

Chain	Residue
B	ASP10
B	HIS12
B	HIS44
B	HOH337

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 201

Chain	Residue
C	ASP10
C	HIS12
C	HIS44
C	HOH388

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Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDADVLlHAitDAlfG

Chain	Residue	Details
A	SER37-GLY52

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