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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5KZ5

Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold

Functional Information from GO Data
ChainGOidnamespacecontents
10030170molecular_functionpyridoxal phosphate binding
10031071molecular_functioncysteine desulfurase activity
10044571biological_process[2Fe-2S] cluster assembly
20030170molecular_functionpyridoxal phosphate binding
20031071molecular_functioncysteine desulfurase activity
20044571biological_process[2Fe-2S] cluster assembly
30030170molecular_functionpyridoxal phosphate binding
30031071molecular_functioncysteine desulfurase activity
30044571biological_process[2Fe-2S] cluster assembly
40030170molecular_functionpyridoxal phosphate binding
40031071molecular_functioncysteine desulfurase activity
40044571biological_process[2Fe-2S] cluster assembly
a0005506molecular_functioniron ion binding
a0016226biological_processiron-sulfur cluster assembly
a0051536molecular_functioniron-sulfur cluster binding
A0004322molecular_functionferroxidase activity
A0005739cellular_componentmitochondrion
A0006879biological_processintracellular iron ion homeostasis
A0008199molecular_functionferric iron binding
A0016226biological_processiron-sulfur cluster assembly
A0018283biological_processiron incorporation into metallo-sulfur cluster
b0005506molecular_functioniron ion binding
b0016226biological_processiron-sulfur cluster assembly
b0051536molecular_functioniron-sulfur cluster binding
B0004322molecular_functionferroxidase activity
B0005739cellular_componentmitochondrion
B0006879biological_processintracellular iron ion homeostasis
B0008199molecular_functionferric iron binding
B0016226biological_processiron-sulfur cluster assembly
B0018283biological_processiron incorporation into metallo-sulfur cluster
c0005506molecular_functioniron ion binding
c0016226biological_processiron-sulfur cluster assembly
c0051536molecular_functioniron-sulfur cluster binding
C0004322molecular_functionferroxidase activity
C0005739cellular_componentmitochondrion
C0006879biological_processintracellular iron ion homeostasis
C0008199molecular_functionferric iron binding
C0016226biological_processiron-sulfur cluster assembly
C0018283biological_processiron incorporation into metallo-sulfur cluster
d0005506molecular_functioniron ion binding
d0016226biological_processiron-sulfur cluster assembly
d0051536molecular_functioniron-sulfur cluster binding
D0004322molecular_functionferroxidase activity
D0005739cellular_componentmitochondrion
D0006879biological_processintracellular iron ion homeostasis
D0008199molecular_functionferric iron binding
D0016226biological_processiron-sulfur cluster assembly
D0018283biological_processiron incorporation into metallo-sulfur cluster
e0005506molecular_functioniron ion binding
e0016226biological_processiron-sulfur cluster assembly
e0051536molecular_functioniron-sulfur cluster binding
E0004322molecular_functionferroxidase activity
E0005739cellular_componentmitochondrion
E0006879biological_processintracellular iron ion homeostasis
E0008199molecular_functionferric iron binding
E0016226biological_processiron-sulfur cluster assembly
E0018283biological_processiron incorporation into metallo-sulfur cluster
f0005506molecular_functioniron ion binding
f0016226biological_processiron-sulfur cluster assembly
f0051536molecular_functioniron-sulfur cluster binding
F0004322molecular_functionferroxidase activity
F0005739cellular_componentmitochondrion
F0006879biological_processintracellular iron ion homeostasis
F0008199molecular_functionferric iron binding
F0016226biological_processiron-sulfur cluster assembly
F0018283biological_processiron incorporation into metallo-sulfur cluster
g0005506molecular_functioniron ion binding
g0016226biological_processiron-sulfur cluster assembly
g0051536molecular_functioniron-sulfur cluster binding
G0004322molecular_functionferroxidase activity
G0005739cellular_componentmitochondrion
G0006879biological_processintracellular iron ion homeostasis
G0008199molecular_functionferric iron binding
G0016226biological_processiron-sulfur cluster assembly
G0018283biological_processiron incorporation into metallo-sulfur cluster
h0005506molecular_functioniron ion binding
h0016226biological_processiron-sulfur cluster assembly
h0051536molecular_functioniron-sulfur cluster binding
H0004322molecular_functionferroxidase activity
H0005739cellular_componentmitochondrion
H0006879biological_processintracellular iron ion homeostasis
H0008199molecular_functionferric iron binding
H0016226biological_processiron-sulfur cluster assembly
H0018283biological_processiron incorporation into metallo-sulfur cluster
i0005506molecular_functioniron ion binding
i0016226biological_processiron-sulfur cluster assembly
i0051536molecular_functioniron-sulfur cluster binding
I0004322molecular_functionferroxidase activity
I0005739cellular_componentmitochondrion
I0006879biological_processintracellular iron ion homeostasis
I0008199molecular_functionferric iron binding
I0016226biological_processiron-sulfur cluster assembly
I0018283biological_processiron incorporation into metallo-sulfur cluster
j0005506molecular_functioniron ion binding
j0016226biological_processiron-sulfur cluster assembly
j0051536molecular_functioniron-sulfur cluster binding
J0004322molecular_functionferroxidase activity
J0005739cellular_componentmitochondrion
J0006879biological_processintracellular iron ion homeostasis
J0008199molecular_functionferric iron binding
J0016226biological_processiron-sulfur cluster assembly
J0018283biological_processiron incorporation into metallo-sulfur cluster
k0005506molecular_functioniron ion binding
k0016226biological_processiron-sulfur cluster assembly
k0051536molecular_functioniron-sulfur cluster binding
K0004322molecular_functionferroxidase activity
K0005739cellular_componentmitochondrion
K0006879biological_processintracellular iron ion homeostasis
K0008199molecular_functionferric iron binding
K0016226biological_processiron-sulfur cluster assembly
K0018283biological_processiron incorporation into metallo-sulfur cluster
l0005506molecular_functioniron ion binding
l0016226biological_processiron-sulfur cluster assembly
l0051536molecular_functioniron-sulfur cluster binding
L0004322molecular_functionferroxidase activity
L0005739cellular_componentmitochondrion
L0006879biological_processintracellular iron ion homeostasis
L0008199molecular_functionferric iron binding
L0016226biological_processiron-sulfur cluster assembly
L0018283biological_processiron incorporation into metallo-sulfur cluster
M0030170molecular_functionpyridoxal phosphate binding
M0031071molecular_functioncysteine desulfurase activity
M0044571biological_process[2Fe-2S] cluster assembly
N0030170molecular_functionpyridoxal phosphate binding
N0031071molecular_functioncysteine desulfurase activity
N0044571biological_process[2Fe-2S] cluster assembly
O0030170molecular_functionpyridoxal phosphate binding
O0031071molecular_functioncysteine desulfurase activity
O0044571biological_process[2Fe-2S] cluster assembly
P0030170molecular_functionpyridoxal phosphate binding
P0031071molecular_functioncysteine desulfurase activity
P0044571biological_process[2Fe-2S] cluster assembly
Q0030170molecular_functionpyridoxal phosphate binding
Q0031071molecular_functioncysteine desulfurase activity
Q0044571biological_process[2Fe-2S] cluster assembly
R0030170molecular_functionpyridoxal phosphate binding
R0031071molecular_functioncysteine desulfurase activity
R0044571biological_process[2Fe-2S] cluster assembly
S0030170molecular_functionpyridoxal phosphate binding
S0031071molecular_functioncysteine desulfurase activity
S0044571biological_process[2Fe-2S] cluster assembly
T0030170molecular_functionpyridoxal phosphate binding
T0031071molecular_functioncysteine desulfurase activity
T0044571biological_process[2Fe-2S] cluster assembly
Functional Information from PROSITE/UniProt
site_idPS00595
Number of Residues20
DetailsAA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDLMsiSGHKiygpk.GvGaI
ChainResidueDetails
1ILE249-ILE268
site_idPS01344
Number of Residues15
DetailsFRATAXIN_1 Frataxin family signature. VINKQtPnkQIWlSS
ChainResidueDetails
HVAL144-SER158
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsActive site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"18650437","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23593335","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29097656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34824239","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues48
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29097656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31101807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34824239","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29097656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31101807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29097656","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WLW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsModified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"29097656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31101807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34824239","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6W1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RTK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsModified residue: {"description":"Cysteine persulfide","evidences":[{"source":"PubMed","id":"18650437","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23593335","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsActive site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"UniProtKB","id":"Q9D7P6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsActive site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"UniProtKB","id":"O29689","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31101807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues12
DetailsModified residue: {"description":"Cysteine persulfide","evidences":[{"source":"UniProtKB","id":"Q9D7P6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsModified residue: {"description":"Cysteine persulfide","evidences":[{"source":"PubMed","id":"24971490","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

250059

PDB entries from 2026-03-04

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