Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
B | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue MLA B 601 |
Chain | Residue |
B | TYR224 |
C | ARG74 |
B | ASP295 |
B | VAL296 |
B | PHE409 |
B | TYR514 |
B | HOH719 |
B | HOH761 |
B | HOH765 |
B | HOH903 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue GOL B 602 |
Chain | Residue |
B | GLN237 |
B | LYS322 |
B | PRO400 |
B | GLU526 |
B | VAL527 |
B | HOH784 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue GOL B 603 |
Chain | Residue |
B | ARG340 |
B | GLU390 |
B | LYS394 |
B | GLU435 |
B | PHE436 |
B | HOH708 |
B | HOH891 |
B | HOH946 |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
C | LYS27-ASP52 | |
site_id | PS00972 |
Number of Residues | 16 |
Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ |
Chain | Residue | Details |
B | GLY215-GLN230 | |
site_id | PS00973 |
Number of Residues | 18 |
Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY |
Chain | Residue | Details |
B | TYR448-TYR465 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
C | ARG54 | |
C | ARG72 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Essential for function |
Chain | Residue | Details |
C | HIS68 | |
Chain | Residue | Details |
C | SER65 | |
Chain | Residue | Details |
C | THR66 | |
Chain | Residue | Details |
C | GLY76 | |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
C | GLY76 | |
Chain | Residue | Details |
C | LYS11 | |
C | LYS48 | |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
C | LYS27 | |
Chain | Residue | Details |
C | LYS29 | |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
C | LYS33 | |
Chain | Residue | Details |
C | LYS63 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
B | PHE234 | electrostatic stabiliser |
B | ARG239 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | PHE480 | proton acceptor, proton donor |
B | ASN497 | electrostatic stabiliser |