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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5KVH

Crystal structure of human apoptosis-inducing factor with W196A mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0046983	molecular_function	protein dimerization activity
B	0016491	molecular_function	oxidoreductase activity
B	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	37
Details	binding site for residue FAD A 701

Chain	Residue
A	GLY138
A	SER176
A	LYS177
A	LYS232
A	VAL233
A	ALA259
A	THR260
A	GLY261
A	PHE284
A	ARG285
A	LEU311
A	GLY139
A	GLY437
A	ASP438
A	GLU453
A	HIS454
A	HIS455
A	ALA458
A	PHE482
A	TRP483
A	HOH818
A	HOH849
A	GLY140
A	HOH852
A	HOH854
A	HOH867
A	HOH882
A	HOH885
A	HOH892
A	HOH904
A	HOH913
A	THR141
A	ALA142
A	VAL162
A	GLU164
A	ARG172
A	PRO173

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 702

Chain	Residue
A	TYR347
A	TRP351
A	PHE508
A	TYR560

site_id	AC3
Number of Residues	38
Details	binding site for residue FAD B 701

Chain	Residue
B	GLY138
B	GLY139
B	GLY140
B	THR141
B	ALA142
B	VAL162
B	GLU164
B	ARG172
B	PRO173
B	SER176
B	LYS177
B	LYS231
B	LYS232
B	VAL233
B	ALA259
B	THR260
B	GLY261
B	PHE284
B	ARG285
B	LEU311
B	GLU314
B	GLY437
B	ASP438
B	GLU453
B	HIS454
B	HIS455
B	ALA458
B	PHE482
B	TRP483
B	HOH805
B	HOH818
B	HOH821
B	HOH822
B	HOH830
B	HOH836
B	HOH841
B	HOH871
B	HOH957

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	GLY138
B	GLY138

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	GLU164
A	ARG172
A	VAL233
A	ASP438
B	GLU164
B	ARG172
B	VAL233
B	ASP438

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	LYS177
B	LYS177

site_id	SWS_FT_FI4
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:24914854, ECO:0007744\|PDB:4BUR

Chain	Residue	Details
A	ALA196
B	GLU336
B	GLY399
B	GLU453
B	GLU493
B	ASN583
A	GLY308
A	GLU336
A	GLY399
A	GLU453
A	GLU493
A	ASN583
B	ALA196
B	GLY308

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:23217327, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH

Chain	Residue	Details
A	ARG285
B	ARG285

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS342
B	LYS342

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:12198487, ECO:0000269\|PubMed:24914854, ECO:0000269\|PubMed:27178839, ECO:0000269\|PubMed:27818101, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6, ECO:0007744\|PDB:5FS7, ECO:0007744\|PDB:5FS8, ECO:0007744\|PDB:5FS9, ECO:0007744\|PDB:5KVH, ECO:0007744\|PDB:5KVI

Chain	Residue	Details
A	HIS454
B	HIS454

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:24914854, ECO:0007744\|PDB:4BUR, ECO:0007744\|PDB:4BV6

Chain	Residue	Details
A	TRP483
B	TRP483

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18691976, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR105
B	THR105

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS109
B	LYS109

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER116
B	SER116

site_id	SWS_FT_FI12
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER118
A	SER371
A	SER524
A	SER530
B	SER118
B	SER371
B	SER524
B	SER530

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER268
B	SER268

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER292
B	SER292

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9Z0X1

Chain	Residue	Details
A	LYS388
A	LYS593
B	LYS388
B	LYS593

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR521
B	THR521

site_id	SWS_FT_FI17
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:22103349

Chain	Residue	Details
A	LYS255
B	LYS255

229380

PDB entries from 2024-12-25

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