5KEG

Crystal structure of APOBEC3A in complex with a single-stranded DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0010526	biological_process	retrotransposon silencing
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	HIS70
A	CYS101
A	CYS106
A	CL203

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site_id	AC2
Number of Residues	6
Details	binding site for residue CL A 203

Chain	Residue
B	DC3
A	HIS70
A	PRO100
A	CYS101
A	CYS106
A	ZN201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	ALA72

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS70
A	CYS101
A	CYS106

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