5KEG
Crystal structure of APOBEC3A in complex with a single-stranded DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000932 | cellular_component | P-body |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004126 | molecular_function | cytidine deaminase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0010526 | biological_process | transposable element silencing |
| A | 0016554 | biological_process | cytidine to uridine editing |
| A | 0044029 | biological_process | positive regulation of gene expression via chromosomal CpG island demethylation |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0045071 | biological_process | negative regulation of viral genome replication |
| A | 0045087 | biological_process | innate immune response |
| A | 0045869 | biological_process | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| A | 0051607 | biological_process | defense response to virus |
| A | 0070383 | biological_process | DNA cytosine deamination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 201 |
| Chain | Residue |
| A | HIS70 |
| A | CYS101 |
| A | CYS106 |
| A | CL203 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 203 |
| Chain | Residue |
| B | DC3 |
| A | HIS70 |
| A | PRO100 |
| A | CYS101 |
| A | CYS106 |
| A | ZN201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 116 |
| Details | Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
