5K97

Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SM A 401

Chain	Residue
A	GLY2
A	GLU160
A	ASP181
A	SM403
A	SM404
A	HOH689
E	DT7

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SM A 402

Chain	Residue
A	GLU160
A	SM404
A	HOH525
E	HOH113
A	ASP86
A	GLU158

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SM A 403

Chain	Residue
A	GLU160
A	ASP179
A	ASP181
A	SM401
E	DT7

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SM A 404

Chain	Residue
A	GLU158
A	GLU160
A	SM401
A	SM402
A	HOH525
E	DT7
E	HOH103
E	HOH113

---

site_id	AC5
Number of Residues	6
Details	binding site for residue K A 405

Chain	Residue
A	SER237
A	ILE238
A	ILE241
A	HOH640
D	DT5
D	HOH131

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SM A 406

Chain	Residue
A	GLU57
A	GLU285
A	GLU313
A	GLN342
A	HOH537
A	HOH588
A	HOH598

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SM A 407

Chain	Residue
A	GLU57
A	GLU59
A	GLU313
A	GLN342
A	HOH589
A	HOH639
A	HOH668

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SM A 408

Chain	Residue
A	GLY49
A	ASP51
A	HOH724
A	HOH803

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SM A 409

Chain	Residue
A	GLU102
A	HOH545
A	HOH891
A	HOH901

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO A 410

Chain	Residue
A	GLY2
A	ILE3
A	ASP179
A	MET180
A	HOH596
E	DG8

---

Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPvYVFDGkpPqLK

Chain	Residue	Details
A	ILE79-LYS93

---

site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GIPYLdAPsEAEASC

Chain	Residue	Details
A	GLY149-CYS163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	Region: {"description":"I-domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15616578","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5FV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"5ZOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK2","evidences":[{"source":"HAMAP-Rule","id":"MF_03140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20729856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---