5K77
Dbr1 in complex with 7-mer branched RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| C | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| C | 0000398 | biological_process | mRNA splicing, via spliceosome |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006397 | biological_process | mRNA processing |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| D | 0000398 | biological_process | mRNA splicing, via spliceosome |
| D | 0003723 | molecular_function | RNA binding |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| E | 0000375 | biological_process | RNA splicing, via transesterification reactions |
| E | 0000398 | biological_process | mRNA splicing, via spliceosome |
| E | 0003723 | molecular_function | RNA binding |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006397 | biological_process | mRNA processing |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0008419 | molecular_function | RNA lariat debranching enzyme activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0048471 | cellular_component | perinuclear region of cytoplasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS14 |
| A | HIS16 |
| A | ASP45 |
| A | HIS232 |
| A | FE2402 |
| A | OH408 |
| v | G510 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue FE2 A 402 |
| Chain | Residue |
| A | HIS180 |
| A | HIS230 |
| A | ZN401 |
| A | OH408 |
| v | G510 |
| A | ASP45 |
| A | ASN90 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ARG50 |
| A | ASN95 |
| A | HIS99 |
| A | PRO146 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | LYS18 |
| A | TYR64 |
| A | LYS249 |
| A | TYR252 |
| V | A501 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS320 |
| A | TYR321 |
| B | TYR74 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | TYR74 |
| A | HOH547 |
| D | LYS320 |
| D | TYR321 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | LYS289 |
| A | THR338 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue OH A 408 |
| Chain | Residue |
| A | CYS14 |
| A | ASP45 |
| A | HIS180 |
| A | HIS230 |
| A | HIS232 |
| A | ZN401 |
| A | FE2402 |
| v | G510 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue FE2 B 401 |
| Chain | Residue |
| B | ASP45 |
| B | ASN90 |
| B | HIS180 |
| B | HIS230 |
| B | ZN402 |
| B | OH407 |
| w | G510 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | CYS14 |
| B | HIS16 |
| B | ASP45 |
| B | HIS232 |
| B | FE2401 |
| B | OH407 |
| w | G510 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ARG50 |
| B | ASN95 |
| B | HIS99 |
| B | PRO146 |
| B | HOH513 |
| B | HOH559 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | LYS18 |
| B | LYS249 |
| W | A501 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | GLN184 |
| B | GLY185 |
| B | LYS215 |
| B | HOH510 |
| B | HOH557 |
| C | THR307 |
| C | LYS308 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | THR307 |
| B | LYS308 |
| C | LYS215 |
| C | HOH546 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue OH B 407 |
| Chain | Residue |
| B | CYS14 |
| B | ASP45 |
| B | HIS180 |
| B | HIS230 |
| B | HIS232 |
| B | FE2401 |
| B | ZN402 |
| w | G510 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 401 |
| Chain | Residue |
| C | CYS14 |
| C | HIS16 |
| C | ASP45 |
| C | HIS232 |
| C | FE2402 |
| C | OH410 |
| x | G510 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue FE2 C 402 |
| Chain | Residue |
| C | ASP45 |
| C | ASN90 |
| C | HIS180 |
| C | HIS230 |
| C | ZN401 |
| C | OH410 |
| x | G510 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| C | PRO146 |
| C | HOH505 |
| C | HOH516 |
| C | HOH574 |
| C | ARG50 |
| C | ASN95 |
| C | HIS99 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | LYS320 |
| C | TYR321 |
| C | HOH503 |
| C | HOH515 |
| D | TYR51 |
| D | TYR74 |
| D | THR332 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 405 |
| Chain | Residue |
| C | GLN199 |
| C | CYS233 |
| C | GLU234 |
| C | ASN254 |
| C | HOH598 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 406 |
| Chain | Residue |
| C | LYS18 |
| C | LYS249 |
| X | A501 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 407 |
| Chain | Residue |
| C | LYS189 |
| C | GLU238 |
| C | GLU239 |
| C | GLY240 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 408 |
| Chain | Residue |
| C | ARG20 |
| C | ARG24 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 409 |
| Chain | Residue |
| C | TYR74 |
| C | HOH577 |
| E | LYS320 |
| E | TYR321 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue OH C 410 |
| Chain | Residue |
| C | CYS14 |
| C | ASP45 |
| C | HIS180 |
| C | HIS230 |
| C | HIS232 |
| C | ZN401 |
| C | FE2402 |
| x | G510 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue FE2 D 401 |
| Chain | Residue |
| D | ASP45 |
| D | ASN90 |
| D | HIS180 |
| D | HIS230 |
| D | ZN402 |
| D | OH408 |
| y | G510 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue ZN D 402 |
| Chain | Residue |
| D | CYS14 |
| D | HIS16 |
| D | ASP45 |
| D | HIS232 |
| D | FE2401 |
| D | OH408 |
| y | G510 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 403 |
| Chain | Residue |
| D | ARG50 |
| D | ASN95 |
| D | HIS99 |
| D | PRO146 |
| D | HOH517 |
| D | HOH533 |
| D | HOH550 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 404 |
| Chain | Residue |
| D | SER172 |
| D | GLN173 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 405 |
| Chain | Residue |
| D | GLN163 |
| D | SER298 |
| D | ILE299 |
| D | SER300 |
| D | HOH590 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 406 |
| Chain | Residue |
| D | GLY68 |
| D | HIS71 |
| D | LEU72 |
| D | HOH599 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 407 |
| Chain | Residue |
| D | LYS18 |
| D | TYR64 |
| D | LYS249 |
| D | TYR252 |
| Y | A501 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue OH D 408 |
| Chain | Residue |
| D | CYS14 |
| D | ASP45 |
| D | HIS180 |
| D | HIS230 |
| D | HIS232 |
| D | FE2401 |
| D | ZN402 |
| y | G510 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue FE2 E 401 |
| Chain | Residue |
| E | ASP45 |
| E | ASN90 |
| E | HIS180 |
| E | HIS230 |
| E | ZN402 |
| E | OH407 |
| z | G510 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue ZN E 402 |
| Chain | Residue |
| E | CYS14 |
| E | HIS16 |
| E | ASP45 |
| E | HIS232 |
| E | FE2401 |
| E | OH407 |
| z | G510 |
| site_id | AF9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 E 403 |
| Chain | Residue |
| E | ARG50 |
| E | ASN95 |
| E | HIS99 |
| E | PRO146 |
| E | HOH509 |
| E | HOH529 |
| E | HOH545 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 E 404 |
| Chain | Residue |
| E | LYS18 |
| E | TYR64 |
| E | LYS249 |
| E | TYR252 |
| Z | A501 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 E 405 |
| Chain | Residue |
| E | GLN163 |
| E | SER298 |
| E | ILE299 |
| E | SER300 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 E 406 |
| Chain | Residue |
| B | LYS320 |
| B | TYR321 |
| E | TYR51 |
| E | TYR74 |
| E | HOH570 |
| site_id | AG4 |
| Number of Residues | 8 |
| Details | binding site for residue OH E 407 |
| Chain | Residue |
| E | CYS14 |
| E | ASP45 |
| E | HIS180 |
| E | HIS230 |
| E | HIS232 |
| E | FE2401 |
| E | ZN402 |
| z | G510 |
| site_id | AG5 |
| Number of Residues | 25 |
| Details | binding site for Di-nucleotide G G 510 and A V 501 |
| Chain | Residue |
| A | HIS16 |
| A | ASP45 |
| A | GLN47 |
| A | VAL60 |
| A | PRO61 |
| A | TYR64 |
| A | ASN90 |
| A | GLY201 |
| A | PHE202 |
| A | ASP205 |
| A | LEU209 |
| A | HIS230 |
| A | MET231 |
| A | HIS232 |
| A | LYS249 |
| A | ZN401 |
| A | FE2402 |
| A | SO4404 |
| A | OH408 |
| A | HOH529 |
| A | HOH534 |
| v | U511 |
| v | HOH601 |
| V | A500 |
| V | C502 |
| site_id | AG6 |
| Number of Residues | 22 |
| Details | binding site for Di-nucleotide G H 510 and A W 501 |
| Chain | Residue |
| B | HIS16 |
| B | ASP45 |
| B | GLN47 |
| B | PRO61 |
| B | LYS63 |
| B | TYR64 |
| B | ASN90 |
| B | GLY201 |
| B | ASP205 |
| B | LEU209 |
| B | HIS230 |
| B | MET231 |
| B | HIS232 |
| B | LYS249 |
| B | FE2401 |
| B | ZN402 |
| B | SO4404 |
| B | OH407 |
| B | HOH549 |
| w | U511 |
| W | A500 |
| W | C502 |
| site_id | AG7 |
| Number of Residues | 25 |
| Details | binding site for Di-nucleotide G I 510 and A X 501 |
| Chain | Residue |
| C | HIS16 |
| C | ASP45 |
| C | GLN47 |
| C | VAL60 |
| C | PRO61 |
| C | TYR64 |
| C | ASN90 |
| C | GLY201 |
| C | PHE202 |
| C | ASP205 |
| C | LEU209 |
| C | HIS230 |
| C | MET231 |
| C | HIS232 |
| C | LYS249 |
| C | ZN401 |
| C | FE2402 |
| C | SO4406 |
| C | OH410 |
| C | HOH532 |
| C | HOH592 |
| x | U511 |
| x | HOH601 |
| X | A500 |
| X | C502 |
| site_id | AG8 |
| Number of Residues | 23 |
| Details | binding site for Di-nucleotide G J 510 and A Y 501 |
| Chain | Residue |
| D | HIS16 |
| D | ASP45 |
| D | GLN47 |
| D | VAL60 |
| D | PRO61 |
| D | TYR64 |
| D | ASN90 |
| D | GLY201 |
| D | PHE202 |
| D | ASP205 |
| D | LEU209 |
| D | HIS230 |
| D | MET231 |
| D | HIS232 |
| D | LYS249 |
| D | FE2401 |
| D | ZN402 |
| D | SO4407 |
| D | OH408 |
| D | HOH523 |
| y | U511 |
| Y | A500 |
| Y | C502 |
| site_id | AG9 |
| Number of Residues | 23 |
| Details | binding site for Di-nucleotide G K 510 and A Z 501 |
| Chain | Residue |
| E | HIS16 |
| E | ASP45 |
| E | GLN47 |
| E | VAL60 |
| E | PRO61 |
| E | TYR64 |
| E | ASN90 |
| E | GLY201 |
| E | PHE202 |
| E | ASP205 |
| E | LEU209 |
| E | HIS230 |
| E | MET231 |
| E | HIS232 |
| E | LYS249 |
| E | FE2401 |
| E | ZN402 |
| E | SO4404 |
| E | OH407 |
| z | U511 |
| Z | A500 |
| Z | C502 |
| Z | HOH602 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27930312, ECO:0000269|PubMed:28504306, ECO:0007744|PDB:5K73, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78, ECO:0007744|PDB:5UKI |
| Chain | Residue | Details |
| A | CYS14 | |
| E | HIS16 | |
| A | HIS16 | |
| B | CYS14 | |
| B | HIS16 | |
| C | CYS14 | |
| C | HIS16 | |
| D | CYS14 | |
| D | HIS16 | |
| E | CYS14 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0000269|PubMed:28504306, ECO:0007744|PDB:4PEF, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K73, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78, ECO:0007744|PDB:5UKI |
| Chain | Residue | Details |
| A | ASP45 | |
| E | HIS180 | |
| A | HIS180 | |
| B | ASP45 | |
| B | HIS180 | |
| C | ASP45 | |
| C | HIS180 | |
| D | ASP45 | |
| D | HIS180 | |
| E | ASP45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|Ref.6, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:8DZK |
| Chain | Residue | Details |
| A | LYS59 | |
| D | LYS59 | |
| D | LYS134 | |
| D | HIS156 | |
| E | LYS59 | |
| E | LYS134 | |
| E | HIS156 | |
| A | LYS134 | |
| A | HIS156 | |
| B | LYS59 | |
| B | LYS134 | |
| B | HIS156 | |
| C | LYS59 | |
| C | LYS134 | |
| C | HIS156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|Ref.6, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:8DZK |
| Chain | Residue | Details |
| A | ASN90 | |
| B | ASN90 | |
| C | ASN90 | |
| D | ASN90 | |
| E | ASN90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI |
| Chain | Residue | Details |
| A | ALA91 | |
| B | ALA91 | |
| C | ALA91 | |
| D | ALA91 | |
| E | ALA91 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78 |
| Chain | Residue | Details |
| A | GLY201 | |
| E | HIS232 | |
| A | HIS232 | |
| B | GLY201 | |
| B | HIS232 | |
| C | GLY201 | |
| C | HIS232 | |
| D | GLY201 | |
| D | HIS232 | |
| E | GLY201 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25123664, ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEH, ECO:0007744|PDB:4PEI, ECO:0007744|PDB:5K77, ECO:0007744|PDB:5K78 |
| Chain | Residue | Details |
| A | ASP205 | |
| B | ASP205 | |
| C | ASP205 | |
| D | ASP205 | |
| E | ASP205 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27930312, ECO:0007744|PDB:4PEG, ECO:0007744|PDB:4PEI |
| Chain | Residue | Details |
| A | HIS230 | |
| E | MET231 | |
| A | MET231 | |
| B | HIS230 | |
| B | MET231 | |
| C | HIS230 | |
| C | MET231 | |
| D | HIS230 | |
| D | MET231 | |
| E | HIS230 |
