Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5K1A

Crystal structure of the UAF1-USP12 complex in C2 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0003677	molecular_function	DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005768	cellular_component	endosome
B	0005770	cellular_component	late endosome
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0007283	biological_process	spermatogenesis
B	0007338	biological_process	single fertilization
B	0008584	biological_process	male gonad development
B	0035264	biological_process	multicellular organism growth
B	0035800	molecular_function	deubiquitinase activator activity
B	0043130	molecular_function	ubiquitin binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043588	biological_process	skin development
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0048568	biological_process	embryonic organ development
B	0048705	biological_process	skeletal system morphogenesis
B	0048872	biological_process	homeostasis of number of cells
B	0050679	biological_process	positive regulation of epithelial cell proliferation
B	0072520	biological_process	seminiferous tubule development
B	1902525	biological_process	regulation of protein monoubiquitination
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0016579	biological_process	protein deubiquitination
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005768	cellular_component	endosome
D	0005770	cellular_component	late endosome
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0007338	biological_process	single fertilization
D	0008584	biological_process	male gonad development
D	0035264	biological_process	multicellular organism growth
D	0035800	molecular_function	deubiquitinase activator activity
D	0043130	molecular_function	ubiquitin binding
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043588	biological_process	skin development
D	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
D	0048568	biological_process	embryonic organ development
D	0048705	biological_process	skeletal system morphogenesis
D	0048872	biological_process	homeostasis of number of cells
D	0050679	biological_process	positive regulation of epithelial cell proliferation
D	0072520	biological_process	seminiferous tubule development
D	1902525	biological_process	regulation of protein monoubiquitination
D	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	0004843	molecular_function	cysteine-type deubiquitinase activity
E	0016579	biological_process	protein deubiquitination
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0003677	molecular_function	DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005768	cellular_component	endosome
F	0005770	cellular_component	late endosome
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006974	biological_process	DNA damage response
F	0007283	biological_process	spermatogenesis
F	0007338	biological_process	single fertilization
F	0008584	biological_process	male gonad development
F	0035264	biological_process	multicellular organism growth
F	0035800	molecular_function	deubiquitinase activator activity
F	0043130	molecular_function	ubiquitin binding
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043588	biological_process	skin development
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0048568	biological_process	embryonic organ development
F	0048705	biological_process	skeletal system morphogenesis
F	0048872	biological_process	homeostasis of number of cells
F	0050679	biological_process	positive regulation of epithelial cell proliferation
F	0072520	biological_process	seminiferous tubule development
F	1902525	biological_process	regulation of protein monoubiquitination
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	0016579	biological_process	protein deubiquitination
H	0000724	biological_process	double-strand break repair via homologous recombination
H	0003677	molecular_function	DNA binding
H	0003690	molecular_function	double-stranded DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005768	cellular_component	endosome
H	0005770	cellular_component	late endosome
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006974	biological_process	DNA damage response
H	0007283	biological_process	spermatogenesis
H	0007338	biological_process	single fertilization
H	0008584	biological_process	male gonad development
H	0035264	biological_process	multicellular organism growth
H	0035800	molecular_function	deubiquitinase activator activity
H	0043130	molecular_function	ubiquitin binding
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0043588	biological_process	skin development
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0048568	biological_process	embryonic organ development
H	0048705	biological_process	skeletal system morphogenesis
H	0048872	biological_process	homeostasis of number of cells
H	0050679	biological_process	positive regulation of epithelial cell proliferation
H	0072520	biological_process	seminiferous tubule development
H	1902525	biological_process	regulation of protein monoubiquitination
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS186
A	CYS189
A	CYS233
A	CYS236

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS186
C	CYS189
C	CYS233
C	CYS236

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN E 401

Chain	Residue
E	CYS189
E	CYS233
E	CYS236
E	CYS186

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN G 401

Chain	Residue
G	CYS186
G	CYS189
G	CYS233
G	CYS236

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA

Chain	Residue	Details
B	LEU90-ALA104
B	VAL132-VAL146

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYCNSvLQ

Chain	Residue	Details
A	GLY40-GLN55

site_id	PS00973
Number of Residues	19
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY

Chain	Residue	Details
A	TYR300-TYR318

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q8BH57

Chain	Residue	Details
B	TYR28
D	TYR28
F	TYR28
H	TYR28

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
B	LYS214
D	LYS214
F	LYS214
H	LYS214

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q8BH57

Chain	Residue	Details
B	LYS578
D	LYS578
F	LYS578
H	LYS578

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
B	THR613
G	CYS189
G	CYS233
G	CYS236
D	THR613
F	THR613
H	THR613
C	CYS233
C	CYS236
E	CYS189
E	CYS233
E	CYS236

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)