5K0I
mpges1 bound to an inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001516 | biological_process | prostaglandin biosynthetic process |
A | 0004364 | molecular_function | glutathione transferase activity |
A | 0004602 | molecular_function | glutathione peroxidase activity |
A | 0004667 | molecular_function | prostaglandin-D synthase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005641 | cellular_component | nuclear envelope lumen |
A | 0005737 | cellular_component | cytoplasm |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0006693 | biological_process | prostaglandin metabolic process |
A | 0007165 | biological_process | signal transduction |
A | 0008283 | biological_process | cell population proliferation |
A | 0008285 | biological_process | negative regulation of cell population proliferation |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0016853 | molecular_function | isomerase activity |
A | 0019233 | biological_process | sensory perception of pain |
A | 0031620 | biological_process | regulation of fever generation |
A | 0032308 | biological_process | positive regulation of prostaglandin secretion |
A | 0043295 | molecular_function | glutathione binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0050220 | molecular_function | prostaglandin-E synthase activity |
A | 0050727 | biological_process | regulation of inflammatory response |
A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 80 |
Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 11 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"18682561","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TL9","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Site: {"description":"Essential for protaglandin-E synthase activity","evidences":[{"source":"PubMed","id":"26755582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27684486","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |