5K0I

mpges1 bound to an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005515	molecular_function	protein binding
A	0005641	cellular_component	nuclear envelope lumen
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006693	biological_process	prostaglandin metabolic process
A	0007165	biological_process	signal transduction
A	0008283	biological_process	cell population proliferation
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0019233	biological_process	sensory perception of pain
A	0031620	biological_process	regulation of fever generation
A	0032308	biological_process	positive regulation of prostaglandin secretion
A	0043295	molecular_function	glutathione binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050220	molecular_function	prostaglandin-E synthase activity
A	0050727	biological_process	regulation of inflammatory response
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18682561","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23431194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BPM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YK5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4YL3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5T37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TL9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Essential for protaglandin-E synthase activity","evidences":[{"source":"PubMed","id":"26755582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27684486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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