5JXF

Crystal structure of Flavobacterium psychrophilum DPP11 in complex with dipeptide Arg-Asp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0043171	biological_process	peptide catabolic process
A	0070009	molecular_function	serine-type aminopeptidase activity
B	0004177	molecular_function	aminopeptidase activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0008239	molecular_function	dipeptidyl-peptidase activity
B	0043171	biological_process	peptide catabolic process
B	0070009	molecular_function	serine-type aminopeptidase activity
C	0004177	molecular_function	aminopeptidase activity
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0008239	molecular_function	dipeptidyl-peptidase activity
C	0043171	biological_process	peptide catabolic process
C	0070009	molecular_function	serine-type aminopeptidase activity
D	0004177	molecular_function	aminopeptidase activity
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0043171	biological_process	peptide catabolic process
D	0070009	molecular_function	serine-type aminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ARG A 801

Chain	Residue
A	HIS83
A	ASP207
A	ASN210
A	TRP211
A	ALA321
A	ASN325
A	PHE660
A	ASP661
A	ASP802

---

site_id	AC2
Number of Residues	11
Details	binding site for residue ASP A 802

Chain	Residue
A	TRP211
A	THR640
A	GLY641
A	GLY642
A	ASN643
A	SER644
A	PHE660
A	ASP661
A	ARG662
A	ARG801
A	HOH901

---

site_id	AC3
Number of Residues	10
Details	binding site for residue ARG B 801

Chain	Residue
B	HIS83
B	ASP207
B	ASN210
B	TRP211
B	ALA321
B	ASN325
B	PHE660
B	ASP661
B	ASP802
B	HOH1064

---

site_id	AC4
Number of Residues	10
Details	binding site for residue ASP B 802

Chain	Residue
B	HIS83
B	TRP211
B	THR640
B	GLY641
B	GLY642
B	SER644
B	PHE660
B	ARG662
B	ARG801
B	HOH910

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL C 801

Chain	Residue
C	GLY627

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL D 801

Chain	Residue
D	GLY627

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL D 802

Chain	Residue
D	THR639
D	ASN659
D	HOH905

---

site_id	AC8
Number of Residues	3
Details	binding site for residue NA D 803

Chain	Residue
D	GLU258
D	GLY576
D	TYR584

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Charge relay system => ECO:0000250|UniProtKB:V5YM14

Chain	Residue	Details
A	HIS83
D	HIS83
D	ASP219
D	SER644
A	ASP219
A	SER644
B	HIS83
B	ASP219
B	SER644
C	HIS83
C	ASP219
C	SER644

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Is essential for the Asp/Glu P1 specificity of DPP11; involved in the recognition of the Asp/Glu residue at the P1 position of substrate peptides => ECO:0000250|UniProtKB:B2RID1

Chain	Residue	Details
A	ARG662
B	ARG662
C	ARG662
D	ARG662

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