Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JWE

Crystal structure of H-2Db in complex with the LCMV-derived GP92-101 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0030670	cellular_component	phagocytic vesicle membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042612	cellular_component	MHC class I protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0006968	biological_process	cellular defense response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0030670	cellular_component	phagocytic vesicle membrane
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0042026	biological_process	protein refolding
D	0042612	cellular_component	MHC class I protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0051289	biological_process	protein homotetramerization
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0006968	biological_process	cellular defense response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0010977	biological_process	negative regulation of neuron projection development
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0030670	cellular_component	phagocytic vesicle membrane
F	0033077	biological_process	T cell differentiation in thymus
F	0034756	biological_process	regulation of iron ion transport
F	0042026	biological_process	protein refolding
F	0042612	cellular_component	MHC class I protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0051289	biological_process	protein homotetramerization
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0030670	cellular_component	phagocytic vesicle membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042612	cellular_component	MHC class I protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG75
F	GLN38
F	ARG81
F	LYS83

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 302

Chain	Residue
A	PHE8
A	TYR27
A	ASN30
B	PHE56
B	TYR63

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 B 101

Chain	Residue
B	GLN2
B	LYS3
B	THR4

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 102

Chain	Residue
B	LYS41
B	PHE70
B	THR71
B	TYR78

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL B 103

Chain	Residue
A	TRP204
A	LEU206
A	ARG234
A	GLN242
B	SER11
B	HIS13
B	PRO14
B	PRO15
B	ARG97

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL B 104

Chain	Residue
B	TYR26
B	SER57
B	TYR63

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL B 105

Chain	Residue
A	ARG234
B	ILE7
B	GLN8
B	VAL9
B	TYR94
B	ASP96
B	MET99

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL C 301

Chain	Residue
C	PRO47
C	ARG48
C	ALA49
C	PRO50
C	GLU53

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 D 101

Chain	Residue
D	LYS41
D	PHE70
D	THR71
D	TYR78

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 D 102

Chain	Residue
D	GLN2
D	LYS3
D	THR4

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL D 103

Chain	Residue
C	PHE8
C	TYR27
C	ASN30
D	PHE56
D	TYR63
D	GOL106
D	HOH201
D	HOH213
D	HOH216

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL D 104

Chain	Residue
C	TRP204
C	ARG234
D	SER11
D	PRO14
D	TRP95
D	ARG97
D	MET99

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL D 105

Chain	Residue
C	VAL231
C	ARG234
D	GLN8
D	VAL9
D	VAL93
D	MET99
D	HOH208

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL D 106

Chain	Residue
D	TYR26
D	SER57
D	GOL103
D	HOH213

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL E 301

Chain	Residue
E	PHE8
E	TYR27
E	ASN30
F	PHE56
F	TYR63

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 F 101

Chain	Residue
F	LYS41
F	PHE70
F	THR71
F	TYR78

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 F 102

Chain	Residue
F	LYS3
F	THR4

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 F 103

Chain	Residue
F	ARG12
F	HOH203
F	HOH205

site_id	AE1
Number of Residues	7
Details	binding site for residue GOL F 104

Chain	Residue
E	ARG234
E	GLN242
F	SER11
F	PRO14
F	TRP95
F	ARG97
F	MET99

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 G 301

Chain	Residue
G	PRO15
G	ALA89
G	GLY90

site_id	AE3
Number of Residues	6
Details	binding site for residue GOL G 302

Chain	Residue
G	TYR27
G	ASN30
H	PHE56
H	LYS58
H	TYR63
G	PHE8

site_id	AE4
Number of Residues	2
Details	binding site for residue GOL G 303

Chain	Residue
G	ARG21
H	GOL106

site_id	AE5
Number of Residues	5
Details	binding site for residue SO4 H 101

Chain	Residue
H	LYS41
H	PHE70
H	THR71
H	TYR78
H	HOH203

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 H 102

Chain	Residue
H	GLN2
H	LYS3
H	THR4

site_id	AE7
Number of Residues	1
Details	binding site for residue SO4 H 103

Chain	Residue
H	ARG12

site_id	AE8
Number of Residues	4
Details	binding site for residue SO4 H 104

Chain	Residue
C	ARG75
H	GLN38
H	ARG81
H	LYS83

site_id	AE9
Number of Residues	1
Details	binding site for residue GOL H 105

Chain	Residue
H	ARG81

site_id	AF1
Number of Residues	4
Details	binding site for residue GOL H 106

Chain	Residue
G	GOL303
H	ILE35
H	ILE37
H	MET51

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
C	ASN86
E	ASN86
G	ASN86

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
C	ASN176
E	ASN176
G	ASN176

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
C	ASN256
E	ASN256
G	ASN256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)