5JWA
the structure of malaria PfNDH2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0003960 | molecular_function | quinone reductase (NADPH) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| A | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0003954 | molecular_function | NADH dehydrogenase activity |
| H | 0003960 | molecular_function | quinone reductase (NADPH) activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| H | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | GLY47 |
| A | THR78 |
| A | PRO79 |
| A | CYS117 |
| A | ALA147 |
| A | VAL148 |
| A | GLY149 |
| A | VAL167 |
| A | THR211 |
| A | GLY353 |
| A | ASP354 |
| A | SER48 |
| A | PRO434 |
| A | THR435 |
| A | ALA436 |
| A | GLN437 |
| A | ALA439 |
| A | MG602 |
| A | MG603 |
| A | MG604 |
| A | MG605 |
| A | HOH752 |
| A | GLY49 |
| A | HOH762 |
| A | HOH772 |
| A | HOH806 |
| A | HOH811 |
| A | HOH819 |
| A | TRP50 |
| A | GLY51 |
| A | ILE69 |
| A | SER70 |
| A | PRO71 |
| A | ARG72 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ALA147 |
| A | VAL148 |
| A | GLY149 |
| A | ILE352 |
| A | GLY353 |
| A | ASP354 |
| A | CYS355 |
| A | FAD601 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | GLY49 |
| A | GLY51 |
| A | GLY52 |
| A | ALA147 |
| A | FAD601 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 604 |
| Chain | Residue |
| A | GLY49 |
| A | ARG72 |
| A | THR76 |
| A | FAD601 |
| A | HOH772 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 605 |
| Chain | Residue |
| A | GLY149 |
| A | ALA150 |
| A | LYS168 |
| A | ASP354 |
| A | FAD601 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue TRT A 606 |
| Chain | Residue |
| A | TYR527 |
| H | TRP511 |
| H | PHE518 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue TRT A 607 |
| Chain | Residue |
| A | GLN506 |
| A | ARG514 |
| A | TRT608 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue TRT A 608 |
| Chain | Residue |
| A | LYS501 |
| A | ILE505 |
| A | PHE521 |
| A | LYS525 |
| A | TRT607 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 609 |
| Chain | Residue |
| A | TRP500 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 610 |
| Chain | Residue |
| A | ASP221 |
| A | LYS225 |
| A | HIS479 |
| A | ARG529 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 612 |
| Chain | Residue |
| A | TYR231 |
| A | LYS232 |
| A | ASP233 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 613 |
| Chain | Residue |
| A | GLY87 |
| A | THR88 |
| A | ASP520 |
| A | LYS523 |
| A | THR524 |
| A | HOH837 |
| site_id | AD4 |
| Number of Residues | 35 |
| Details | binding site for residue FAD H 601 |
| Chain | Residue |
| H | THR211 |
| H | GLY353 |
| H | ASP354 |
| H | PRO434 |
| H | THR435 |
| H | ALA436 |
| H | GLN437 |
| H | ALA439 |
| H | TYR504 |
| H | MG602 |
| H | MG603 |
| H | MG604 |
| H | MG605 |
| H | HOH734 |
| H | HOH768 |
| H | HOH794 |
| H | HOH799 |
| H | HOH817 |
| H | GLY47 |
| H | SER48 |
| H | GLY49 |
| H | TRP50 |
| H | GLY51 |
| H | ILE69 |
| H | SER70 |
| H | PRO71 |
| H | ARG72 |
| H | THR78 |
| H | PRO79 |
| H | GLU116 |
| H | CYS117 |
| H | ALA147 |
| H | VAL148 |
| H | GLY149 |
| H | VAL167 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue MG H 602 |
| Chain | Residue |
| H | ALA147 |
| H | VAL148 |
| H | GLY149 |
| H | ILE352 |
| H | GLY353 |
| H | ASP354 |
| H | CYS355 |
| H | FAD601 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MG H 603 |
| Chain | Residue |
| H | GLY47 |
| H | GLY49 |
| H | GLY51 |
| H | GLY52 |
| H | ALA147 |
| H | FAD601 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue MG H 604 |
| Chain | Residue |
| H | GLY49 |
| H | ARG72 |
| H | THR76 |
| H | FAD601 |
| H | HOH799 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MG H 605 |
| Chain | Residue |
| H | GLY149 |
| H | ALA150 |
| H | LYS168 |
| H | ASP354 |
| H | FAD601 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue TRT H 606 |
| Chain | Residue |
| A | TRP511 |
| A | PHE518 |
| H | TYR527 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue TRT H 607 |
| Chain | Residue |
| H | LYS501 |
| H | ILE505 |
| H | PHE518 |
| H | PHE521 |
| H | LYS525 |
| H | TRT608 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue TRT H 608 |
| Chain | Residue |
| H | GLN506 |
| H | ARG514 |
| H | TRT607 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue ACT H 609 |
| Chain | Residue |
| H | LEU268 |
| H | ASN269 |
| H | HOH748 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT H 610 |
| Chain | Residue |
| H | ASP221 |
| H | LYS225 |
| H | HIS479 |
| H | ARG529 |
| H | HOH728 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue ACT H 611 |
| Chain | Residue |
| H | TRP500 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue ACT H 612 |
| Chain | Residue |
| A | ARG177 |
| H | ASN92 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue ACT H 613 |
| Chain | Residue |
| H | LYS162 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue ACT H 614 |
| Chain | Residue |
| H | ILE157 |
| H | VAL206 |
| H | TYR277 |
| H | VAL278 |
| H | SER309 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue ACT H 615 |
| Chain | Residue |
| H | PHE460 |
