5JMN
Fusidic acid bound AcrB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015567 | molecular_function | alkane transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0015895 | biological_process | alkane transport |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0042930 | biological_process | enterobactin transport |
| B | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009410 | biological_process | response to xenobiotic stimulus |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| C | 0015562 | molecular_function | efflux transmembrane transporter activity |
| C | 0015567 | molecular_function | alkane transmembrane transporter activity |
| C | 0015721 | biological_process | bile acid and bile salt transport |
| C | 0015895 | biological_process | alkane transport |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022857 | molecular_function | transmembrane transporter activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042908 | biological_process | xenobiotic transport |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0042930 | biological_process | enterobactin transport |
| C | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098567 | cellular_component | periplasmic side of plasma membrane |
| C | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| C | 1990281 | cellular_component | efflux pump complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FUA A 1101 |
| Chain | Residue |
| A | ILE27 |
| A | LYS334 |
| A | HIS338 |
| A | VAL341 |
| A | LMT1103 |
| A | HOH1201 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1102 |
| Chain | Residue |
| A | ALA890 |
| A | LEU891 |
| C | ARG8 |
| C | PHE11 |
| A | GLY440 |
| A | GLY444 |
| A | CYS887 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue LMT A 1103 |
| Chain | Residue |
| A | ILE27 |
| A | VAL32 |
| A | VAL341 |
| A | ILE348 |
| A | FUA1101 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue LMT A 1104 |
| Chain | Residue |
| A | ARG8 |
| A | PHE11 |
| B | GLN439 |
| B | GLY440 |
| B | VAL443 |
| B | GLY444 |
| B | P3G1110 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1105 |
| Chain | Residue |
| A | ARG185 |
| A | GLU273 |
| A | GLY755 |
| A | TYR772 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1106 |
| Chain | Residue |
| A | THR696 |
| A | ASN700 |
| A | HOH1340 |
| E | ARG23 |
| E | TRP57 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue ETE A 1107 |
| Chain | Residue |
| A | ALA385 |
| A | HOH1318 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue ETE A 1108 |
| Chain | Residue |
| A | GLY957 |
| A | ARG1031 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue FUA B 1101 |
| Chain | Residue |
| B | LEU300 |
| B | HIS338 |
| B | VAL341 |
| B | LMT1104 |
| B | HOH1308 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue LMT B 1102 |
| Chain | Residue |
| B | SER530 |
| B | GLY533 |
| B | ARG536 |
| B | ARG540 |
| B | TYR541 |
| B | PHE1020 |
| D | ASP72 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue LMT B 1103 |
| Chain | Residue |
| B | ARG363 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue LMT B 1104 |
| Chain | Residue |
| B | ILE27 |
| B | ASN298 |
| B | LEU300 |
| B | ASP301 |
| B | ALA304 |
| B | PHE380 |
| B | FUA1101 |
| B | HOH1202 |
| B | HOH1206 |
| B | HOH1308 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 1105 |
| Chain | Residue |
| B | ARG239 |
| B | TYR758 |
| B | ASN760 |
| B | ASP761 |
| C | PRO119 |
| C | GLN120 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 1106 |
| Chain | Residue |
| B | GLN108 |
| B | MET115 |
| B | VAL127 |
| C | GLN112 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue PTY B 1107 |
| Chain | Residue |
| B | PHE899 |
| B | PHE1033 |
| B | HOH1314 |
| B | HOH1323 |
| B | HOH1324 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue D12 B 1108 |
| Chain | Residue |
| B | MET1 |
| B | MET447 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue P3G B 1110 |
| Chain | Residue |
| A | LMT1104 |
| B | GLN439 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue D10 B 1112 |
| Chain | Residue |
| A | LYS29 |
| B | VAL454 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue FUA C 1101 |
| Chain | Residue |
| C | LYS334 |
| C | HIS338 |
| C | VAL341 |
| C | LMT1104 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue LMT C 1102 |
| Chain | Residue |
| C | ALA22 |
| C | LEU25 |
| C | ALA26 |
| C | LYS29 |
| C | HOH1230 |
| C | HOH1381 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue LMT C 1103 |
| Chain | Residue |
| C | SER530 |
| C | GLY533 |
| C | ARG536 |
| C | ARG540 |
| C | TYR541 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue LMT C 1104 |
| Chain | Residue |
| C | FUA1101 |
| C | HOH1232 |
| C | LEU28 |
| C | VAL32 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue LMT C 1105 |
| Chain | Residue |
| C | TRP515 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 1106 |
| Chain | Residue |
| C | GLY691 |
| C | HIS692 |
| C | HOH1272 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 1107 |
| Chain | Residue |
| C | ARG185 |
| C | GLU273 |
| C | ASN274 |
| C | GLY755 |
| C | GLY756 |
| C | MET774 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 1108 |
| Chain | Residue |
| C | ALA160 |
| C | ASN161 |
| C | ASP764 |
| C | ARG765 |
| C | ARG767 |
| C | LYS769 |
| C | HOH1222 |
| C | HOH1290 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue PTY C 1109 |
| Chain | Residue |
| C | VAL454 |
| C | PHE458 |
| C | SER875 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue PTY C 1110 |
| Chain | Residue |
| B | ARG8 |
| B | PHE11 |
| C | GLN439 |
| C | LEU891 |
| C | GLU893 |
| C | GLU947 |
| C | HEX1117 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue PTY C 1111 |
| Chain | Residue |
| C | SER894 |
| C | TRP895 |
| C | SER896 |
| C | ARG1030 |
| C | HOH1278 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue D12 C 1112 |
| Chain | Residue |
| C | MET552 |
| C | PHE556 |
| C | VAL557 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue D12 C 1113 |
| Chain | Residue |
| C | GLY387 |
| C | PHE388 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue ETE C 1115 |
| Chain | Residue |
| C | HOH1307 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue HEX C 1117 |
| Chain | Residue |
| C | MET1 |
| C | PTY1110 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 201 |
| Chain | Residue |
| D | ASP143 |
| D | LYS147 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 201 |
| Chain | Residue |
| A | HOH1291 |
| E | ASP143 |
| E | LYS147 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 202 |
| Chain | Residue |
| A | TYR811 |
| E | GLU20 |
| E | ARG23 |
| E | ASP44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1932 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 54 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
