Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JMN

Fusidic acid bound AcrB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015567	molecular_function	alkane transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0015895	biological_process	alkane transport
A	0015908	biological_process	fatty acid transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0042930	biological_process	enterobactin transport
A	0042931	molecular_function	enterobactin transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015567	molecular_function	alkane transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0015895	biological_process	alkane transport
B	0015908	biological_process	fatty acid transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0042930	biological_process	enterobactin transport
B	0042931	molecular_function	enterobactin transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015567	molecular_function	alkane transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0015895	biological_process	alkane transport
C	0015908	biological_process	fatty acid transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0042930	biological_process	enterobactin transport
C	0042931	molecular_function	enterobactin transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FUA A 1101

Chain	Residue
A	ILE27
A	LYS334
A	HIS338
A	VAL341
A	LMT1103
A	HOH1201

site_id	AC2
Number of Residues	7
Details	binding site for residue LMT A 1102

Chain	Residue
A	ALA890
A	LEU891
C	ARG8
C	PHE11
A	GLY440
A	GLY444
A	CYS887

site_id	AC3
Number of Residues	5
Details	binding site for residue LMT A 1103

Chain	Residue
A	ILE27
A	VAL32
A	VAL341
A	ILE348
A	FUA1101

site_id	AC4
Number of Residues	7
Details	binding site for residue LMT A 1104

Chain	Residue
A	ARG8
A	PHE11
B	GLN439
B	GLY440
B	VAL443
B	GLY444
B	P3G1110

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 1105

Chain	Residue
A	ARG185
A	GLU273
A	GLY755
A	TYR772

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 1106

Chain	Residue
A	THR696
A	ASN700
A	HOH1340
E	ARG23
E	TRP57

site_id	AC7
Number of Residues	2
Details	binding site for residue ETE A 1107

Chain	Residue
A	ALA385
A	HOH1318

site_id	AC8
Number of Residues	2
Details	binding site for residue ETE A 1108

Chain	Residue
A	GLY957
A	ARG1031

site_id	AC9
Number of Residues	5
Details	binding site for residue FUA B 1101

Chain	Residue
B	LEU300
B	HIS338
B	VAL341
B	LMT1104
B	HOH1308

site_id	AD1
Number of Residues	7
Details	binding site for residue LMT B 1102

Chain	Residue
B	SER530
B	GLY533
B	ARG536
B	ARG540
B	TYR541
B	PHE1020
D	ASP72

site_id	AD2
Number of Residues	1
Details	binding site for residue LMT B 1103

Chain	Residue
B	ARG363

site_id	AD3
Number of Residues	10
Details	binding site for residue LMT B 1104

Chain	Residue
B	ILE27
B	ASN298
B	LEU300
B	ASP301
B	ALA304
B	PHE380
B	FUA1101
B	HOH1202
B	HOH1206
B	HOH1308

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL B 1105

Chain	Residue
B	ARG239
B	TYR758
B	ASN760
B	ASP761
C	PRO119
C	GLN120

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL B 1106

Chain	Residue
B	GLN108
B	MET115
B	VAL127
C	GLN112

site_id	AD6
Number of Residues	5
Details	binding site for residue PTY B 1107

Chain	Residue
B	PHE899
B	PHE1033
B	HOH1314
B	HOH1323
B	HOH1324

site_id	AD7
Number of Residues	2
Details	binding site for residue D12 B 1108

Chain	Residue
B	MET1
B	MET447

site_id	AD8
Number of Residues	2
Details	binding site for residue P3G B 1110

Chain	Residue
A	LMT1104
B	GLN439

site_id	AD9
Number of Residues	2
Details	binding site for residue D10 B 1112

Chain	Residue
A	LYS29
B	VAL454

site_id	AE1
Number of Residues	4
Details	binding site for residue FUA C 1101

Chain	Residue
C	LYS334
C	HIS338
C	VAL341
C	LMT1104

site_id	AE2
Number of Residues	6
Details	binding site for residue LMT C 1102

Chain	Residue
C	ALA22
C	LEU25
C	ALA26
C	LYS29
C	HOH1230
C	HOH1381

site_id	AE3
Number of Residues	5
Details	binding site for residue LMT C 1103

Chain	Residue
C	SER530
C	GLY533
C	ARG536
C	ARG540
C	TYR541

site_id	AE4
Number of Residues	4
Details	binding site for residue LMT C 1104

Chain	Residue
C	FUA1101
C	HOH1232
C	LEU28
C	VAL32

site_id	AE5
Number of Residues	1
Details	binding site for residue LMT C 1105

Chain	Residue
C	TRP515

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 C 1106

Chain	Residue
C	GLY691
C	HIS692
C	HOH1272

site_id	AE7
Number of Residues	6
Details	binding site for residue GOL C 1107

Chain	Residue
C	ARG185
C	GLU273
C	ASN274
C	GLY755
C	GLY756
C	MET774

site_id	AE8
Number of Residues	8
Details	binding site for residue GOL C 1108

Chain	Residue
C	ALA160
C	ASN161
C	ASP764
C	ARG765
C	ARG767
C	LYS769
C	HOH1222
C	HOH1290

site_id	AE9
Number of Residues	3
Details	binding site for residue PTY C 1109

Chain	Residue
C	VAL454
C	PHE458
C	SER875

site_id	AF1
Number of Residues	7
Details	binding site for residue PTY C 1110

Chain	Residue
B	ARG8
B	PHE11
C	GLN439
C	LEU891
C	GLU893
C	GLU947
C	HEX1117

site_id	AF2
Number of Residues	5
Details	binding site for residue PTY C 1111

Chain	Residue
C	SER894
C	TRP895
C	SER896
C	ARG1030
C	HOH1278

site_id	AF3
Number of Residues	3
Details	binding site for residue D12 C 1112

Chain	Residue
C	MET552
C	PHE556
C	VAL557

site_id	AF4
Number of Residues	2
Details	binding site for residue D12 C 1113

Chain	Residue
C	GLY387
C	PHE388

site_id	AF5
Number of Residues	1
Details	binding site for residue ETE C 1115

Chain	Residue
C	HOH1307

site_id	AF6
Number of Residues	2
Details	binding site for residue HEX C 1117

Chain	Residue
C	MET1
C	PTY1110

site_id	AF7
Number of Residues	2
Details	binding site for residue GOL D 201

Chain	Residue
D	ASP143
D	LYS147

site_id	AF8
Number of Residues	3
Details	binding site for residue GOL E 201

Chain	Residue
A	HOH1291
E	ASP143
E	LYS147

site_id	AF9
Number of Residues	4
Details	binding site for residue GOL E 202

Chain	Residue
A	TYR811
E	GLU20
E	ARG23
E	ASP44

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ILE438
B	ALA491-THR538
B	ALA889-PRO898
B	LEU944-LEU972
B	ILE1019-HIS1049
C	MET1-PRO9
C	LEU357-THR365
C	GLU414-ILE438
C	ALA491-THR538
C	ALA889-PRO898
A	LEU357-THR365
C	LEU944-LEU972
C	ILE1019-HIS1049
A	GLU414-ILE438
A	ALA491-THR538
A	ALA889-PRO898
A	LEU944-LEU972
A	ILE1019-HIS1049
B	MET1-PRO9
B	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE10-LEU28
B	ILE10-LEU28
C	ILE10-LEU28

site_id	SWS_FT_FI3
Number of Residues	1932
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	LYS29-SER336
B	PHE556-ASN871
B	ARG919-ASP924
B	THR993-GLY998
C	LYS29-SER336
C	PHE386-ASN391
C	PHE458-ALA465
C	PHE556-ASN871
C	ARG919-ASP924
C	THR993-GLY998
A	PHE386-ASN391
A	PHE458-ALA465
A	PHE556-ASN871
A	ARG919-ASP924
A	THR993-GLY998
B	LYS29-SER336
B	PHE386-ASN391
B	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ILE337-TYR356
B	ILE337-TYR356
C	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLN439-ALA457
B	GLN439-ALA457
C	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ILE466-PRO490
B	ILE466-PRO490
C	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	GLY539-LEU555
B	GLY539-LEU555
C	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLN872-LEU888
B	GLN872-LEU888
C	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	PHE899-PHE918
B	PHE899-PHE918
C	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	VAL925-ILE943
B	VAL925-ILE943
C	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ARG973-SER992
B	ARG973-SER992
C	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	ALA999-ALA1018
B	ALA999-ALA1018
C	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)