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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JJM

Crystal Structure of Homodimeric Androgen Receptor Ligand-Binding Domain bound to DHT and LxxLL peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue DHT A 1001

Chain	Residue
A	LEU704
A	ASN705
A	GLN711
A	MET742
A	MET749
A	ARG752
A	THR877

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 1002

Chain	Residue
M	FME503
A	PRO849
A	CYS852

site_id	AC3
Number of Residues	1
Details	binding site for residue CL A 1003

Chain	Residue
A	SER851

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 1004

Chain	Residue
A	GLY688
A	ARG710

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 1005

Chain	Residue
A	TRP751
A	PHE754
A	THR755
A	ASN758
A	LEU805

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 1006

Chain	Residue
A	SER696
A	PHE697
A	LYS777
A	ARG779
A	HOH1110
A	HOH1119

site_id	AC7
Number of Residues	8
Details	binding site for residue DHT B 1001

Chain	Residue
B	LEU704
B	ASN705
B	GLN711
B	MET742
B	MET749
B	ARG752
B	PHE764
B	THR877

site_id	AC8
Number of Residues	2
Details	binding site for residue ZN B 1002

Chain	Residue
B	CYS852
F	FME503

site_id	AC9
Number of Residues	1
Details	binding site for residue CL B 1003

Chain	Residue
B	SER851

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO B 1004

Chain	Residue
B	PHE754
B	THR755
B	ASN758
C	TRP751

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO B 1005

Chain	Residue
B	GLY688
B	ARG710

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO B 1006

Chain	Residue
B	ARG846
B	SER851

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 B 1007

Chain	Residue
B	SER696
B	PHE697
B	LYS777
B	ARG779
B	HOH1101
B	HOH1103

site_id	AD5
Number of Residues	7
Details	binding site for residue DHT C 1001

Chain	Residue
C	LEU704
C	ASN705
C	GLN711
C	MET749
C	ARG752
C	PHE764
C	THR877

site_id	AD6
Number of Residues	2
Details	binding site for residue ZN C 1002

Chain	Residue
C	CYS852
K	FME503

site_id	AD7
Number of Residues	2
Details	binding site for residue EDO C 1003

Chain	Residue
C	GLY688
C	ARG710

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL C 1004

Chain	Residue
B	GLU681
B	TRP751
B	PRO801
B	LEU805
C	THR755
C	ASN758

site_id	AD9
Number of Residues	5
Details	binding site for residue PGE C 1005

Chain	Residue
C	HIS776
D	ASN833
D	LYS836
D	ARG840
D	MET886

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 C 1006

Chain	Residue
C	SER696
C	PHE697
C	LYS777
C	ARG779
C	HOH1109

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 C 1007

Chain	Residue
B	LYS836
C	ARG779
C	VAL887

site_id	AE3
Number of Residues	2
Details	binding site for residue ZN D 1002

Chain	Residue
D	CYS852
L	FME503

site_id	AE4
Number of Residues	8
Details	binding site for residue DHT D 1001

Chain	Residue
D	LEU704
D	ASN705
D	GLN711
D	MET745
D	MET749
D	ARG752
D	PHE764
D	THR877

site_id	AE5
Number of Residues	2
Details	binding site for residue CL D 1003

Chain	Residue
D	PRO892
D	GLU893

site_id	AE6
Number of Residues	3
Details	binding site for residue EDO D 1004

Chain	Residue
D	ARG779
D	LYS836
D	VAL887

site_id	AE7
Number of Residues	2
Details	binding site for residue EDO D 1005

Chain	Residue
D	GLY688
D	ARG710

site_id	AE8
Number of Residues	4
Details	binding site for residue ACT D 1006

Chain	Residue
D	LYS825
D	LYS822
D	ASN823
D	GLN824

site_id	AE9
Number of Residues	4
Details	binding site for residue EDO D 1007

Chain	Residue
D	TRP751
D	THR755
D	ASN758
D	LEU805

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 D 1008

Chain	Residue
D	SER696
D	PHE697
D	LYS777
D	ARG779
D	HOH1107
D	HOH1108

site_id	AF2
Number of Residues	10
Details	binding site for Di-peptide FME F 920 and SER F 921

Chain	Residue
B	ASP839
B	ALA843
B	ARG846
B	LYS847
B	ASN848
B	PRO849
B	CYS852
B	ZN1002
C	ILE882
F	ASP505

site_id	AF3
Number of Residues	9
Details	binding site for Di-peptide FME K 503 and SER K 504

Chain	Residue
B	ILE882
C	ASP839
C	ALA843
C	ARG846
C	ASN848
C	PRO849
C	CYS852
C	ZN1002
K	ASP505

site_id	AF4
Number of Residues	9
Details	binding site for Di-peptide FME L 503 and SER L 504

Chain	Residue
D	ASP839
D	ALA843
D	ARG846
D	ASN848
D	PRO849
D	CYS852
D	ILE882
D	ZN1002
L	ASP505

site_id	AF5
Number of Residues	8
Details	binding site for Di-peptide FME M 503 and SER M 504

Chain	Residue
A	CYS669
A	ASP839
A	ALA843
A	ARG846
A	CYS852
A	ILE882
A	ZN1002
M	ASP505

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269\|PubMed:15563469, ECO:0000269\|PubMed:16641486, ECO:0000269\|PubMed:17591767, ECO:0000269\|PubMed:25091737, ECO:0007744\|PDB:1T5Z, ECO:0007744\|PDB:1T63, ECO:0007744\|PDB:1T65, ECO:0007744\|PDB:1XJ7, ECO:0007744\|PDB:2AM9, ECO:0007744\|PDB:2AMA, ECO:0007744\|PDB:2AMB, ECO:0007744\|PDB:2PIO, ECO:0007744\|PDB:2PIP, ECO:0007744\|PDB:2PIR, ECO:0007744\|PDB:2PIT, ECO:0007744\|PDB:2PIU, ECO:0007744\|PDB:2PIV, ECO:0007744\|PDB:2PIW, ECO:0007744\|PDB:2PIX, ECO:0007744\|PDB:2PKL, ECO:0007744\|PDB:2PNU, ECO:0007744\|PDB:2Q7I, ECO:0007744\|PDB:2Q7J, ECO:0007744\|PDB:2Q7K, ECO:0007744\|PDB:2Q7L, ECO:0007744\|PDB:2YHD, ECO:0007744\|PDB:2YLO, ECO:0007744\|PDB:2YLP, ECO:0007744\|PDB:2YLQ, ECO:0007744\|PDB:3L3X, ECO:0007744\|PDB:3L3Z, ECO:0007744\|PDB:3ZQT, ECO:0007744\|PDB:4HLW, ECO:0007744\|PDB:4K7A, ECO:0007744\|PDB:4OEA, ECO:0007744\|PDB:4OED, ECO:0007744\|PDB:4OEY, ECO:0007744\|PDB:4OEZ, ECO:0007744\|PDB:4OFR, ECO:0007744\|PDB:4OFU, ECO:0007744\|PDB:5JJM

Chain	Residue	Details
C	ASN705
D	ASN705
B	ASN705

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:15563469, ECO:0000269\|PubMed:16641486, ECO:0000269\|PubMed:17591767, ECO:0000269\|PubMed:25091737, ECO:0007744\|PDB:1T5Z, ECO:0007744\|PDB:1T63, ECO:0007744\|PDB:1T65, ECO:0007744\|PDB:1XJ7, ECO:0007744\|PDB:2AM9, ECO:0007744\|PDB:2AMA, ECO:0007744\|PDB:2PIO, ECO:0007744\|PDB:2PIP, ECO:0007744\|PDB:2PIQ, ECO:0007744\|PDB:2PIR, ECO:0007744\|PDB:2PIT, ECO:0007744\|PDB:2PIU, ECO:0007744\|PDB:2PIV, ECO:0007744\|PDB:2PIW, ECO:0007744\|PDB:2PIX, ECO:0007744\|PDB:2PKL, ECO:0007744\|PDB:2Q7I, ECO:0007744\|PDB:2Q7J, ECO:0007744\|PDB:2Q7K, ECO:0007744\|PDB:2Q7L, ECO:0007744\|PDB:2YHD, ECO:0007744\|PDB:2YLO, ECO:0007744\|PDB:2YLP, ECO:0007744\|PDB:2YLQ, ECO:0007744\|PDB:2Z4J, ECO:0007744\|PDB:3L3X, ECO:0007744\|PDB:3L3Z, ECO:0007744\|PDB:3ZQT, ECO:0007744\|PDB:4HLW, ECO:0007744\|PDB:4K7A, ECO:0007744\|PDB:4OEA, ECO:0007744\|PDB:4OED, ECO:0007744\|PDB:4OEY, ECO:0007744\|PDB:4OEZ, ECO:0007744\|PDB:4OFR, ECO:0007744\|PDB:4OFU, ECO:0007744\|PDB:5JJM

Chain	Residue	Details
C	THR877
D	ARG752
D	THR877
C	ARG752
B	ARG752
B	THR877

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with coactivator LXXL and FXXFY motifs => ECO:0000269\|PubMed:25091737

Chain	Residue	Details
B	LYS720
C	LYS720
D	LYS720

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000269\|PubMed:25091737

Chain	Residue	Details
B	GLU897
C	GLU897
D	GLU897

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by CSK => ECO:0000269\|PubMed:17045208

Chain	Residue	Details
C	TYR915
B	TYR915
D	TYR915

site_id	SWS_FT_FI6
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:19345326

Chain	Residue	Details
B	LYS845
B	LYS847
C	LYS845
C	LYS847
D	LYS845
D	LYS847

218500

PDB entries from 2024-04-17

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