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5JHW

Crystal Structure of the GDF11:Follistatin 288 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008083molecular_functiongrowth factor activity
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001501biological_processskeletal system development
C0002244biological_processhematopoietic progenitor cell differentiation
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0007276biological_processgamete generation
C0007389biological_processpattern specification process
C0008585biological_processfemale gonad development
C0014070biological_processresponse to organic cyclic compound
C0030154biological_processcell differentiation
C0030509biological_processBMP signaling pathway
C0030510biological_processregulation of BMP signaling pathway
C0030857biological_processnegative regulation of epithelial cell differentiation
C0031069biological_processhair follicle morphogenesis
C0032926biological_processnegative regulation of activin receptor signaling pathway
C0036305biological_processameloblast differentiation
C0038102molecular_functionactivin receptor antagonist activity
C0042475biological_processodontogenesis of dentin-containing tooth
C0043395molecular_functionheparan sulfate proteoglycan binding
C0043616biological_processkeratinocyte proliferation
C0048185molecular_functionactivin binding
C0051798biological_processpositive regulation of hair follicle development
C0071363biological_processcellular response to growth factor stimulus
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001501biological_processskeletal system development
D0002244biological_processhematopoietic progenitor cell differentiation
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0007276biological_processgamete generation
D0007389biological_processpattern specification process
D0008585biological_processfemale gonad development
D0014070biological_processresponse to organic cyclic compound
D0030154biological_processcell differentiation
D0030509biological_processBMP signaling pathway
D0030510biological_processregulation of BMP signaling pathway
D0030857biological_processnegative regulation of epithelial cell differentiation
D0031069biological_processhair follicle morphogenesis
D0032926biological_processnegative regulation of activin receptor signaling pathway
D0036305biological_processameloblast differentiation
D0038102molecular_functionactivin receptor antagonist activity
D0042475biological_processodontogenesis of dentin-containing tooth
D0043395molecular_functionheparan sulfate proteoglycan binding
D0043616biological_processkeratinocyte proliferation
D0048185molecular_functionactivin binding
D0051798biological_processpositive regulation of hair follicle development
D0071363biological_processcellular response to growth factor stimulus
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue PO4 A 201
ChainResidue
AGLU12
ASER13
AARG14
CPRO101
CARG134
DTYR17
DLYS18
DFLC301

site_idAC2
Number of Residues9
Detailsbinding site for residue FLC A 202
ChainResidue
AGLN92
DARG237
DSER239
DGLU265
DLYS269
DLEU278
DGLU280
DHOH414
ALYS90

site_idAC3
Number of Residues6
Detailsbinding site for residue FLC B 201
ChainResidue
BGLY28
BASP30
BTRP31
CALA188
CARG192
DLYS48

site_idAC4
Number of Residues9
Detailsbinding site for residue FLC B 202
ChainResidue
BSER11
BGLU12
BSER13
BARG14
CLYS18
DLYS108
DTHR109
DTYR110
DARG111

site_idAC5
Number of Residues8
Detailsbinding site for residue PO4 C 301
ChainResidue
CVAL142
CCYS144
CTHR149
CCYS150
CLYS232
CSER257
CASN259
CLYS282

site_idAC6
Number of Residues6
Detailsbinding site for residue FLC C 302
ChainResidue
BLYS90
CLEU228
CARG237
CSER239
CLYS269
CLEU278

site_idAC7
Number of Residues6
Detailsbinding site for residue FLC C 303
ChainResidue
BLEU2
BLYS78
BARG105
CARG6
CLYS9
CHOH413

site_idAC8
Number of Residues8
Detailsbinding site for residue FLC D 301
ChainResidue
AARG14
APO4201
CTRP98
CPRO101
CGLY133
CARG134
CLYS136
DLYS18

site_idAC9
Number of Residues6
Detailsbinding site for residue FLC D 302
ChainResidue
ATHR21
AARG37
ALYS39
DARG120
DGLU126
DGLU128

site_idAD1
Number of Residues8
Detailsbinding site for residue PO4 D 303
ChainResidue
DVAL142
DPHE143
DCYS144
DTHR149
DCYS150
DLYS232
DSER257
DASN259

Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IiaPkrYkanyCsGqC
ChainResidueDetails
AILE32-CYS47

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN95
CASN259
DASN95
DASN259

225946

PDB entries from 2024-10-09

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