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5JCP

RhoGAP domain of ARAP3 in complex with RhoA in the transition state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001764biological_processneuron migration
A0001822biological_processkidney development
A0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
A0002363biological_processalpha-beta T cell lineage commitment
A0003100biological_processregulation of systemic arterial blood pressure by endothelin
A0003189biological_processaortic valve formation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007165biological_processsignal transduction
A0007266biological_processRho protein signal transduction
A0007519biological_processskeletal muscle tissue development
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0010975biological_processregulation of neuron projection development
A0016477biological_processcell migration
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0021795biological_processcerebral cortex cell migration
A0021861biological_processforebrain radial glial cell differentiation
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030521biological_processandrogen receptor signaling pathway
A0030667cellular_componentsecretory granule membrane
A0031122biological_processcytoplasmic microtubule organization
A0031982cellular_componentvesicle
A0032154cellular_componentcleavage furrow
A0032467biological_processpositive regulation of cytokinesis
A0032587cellular_componentruffle membrane
A0032956biological_processregulation of actin cytoskeleton organization
A0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
A0033688biological_processregulation of osteoblast proliferation
A0034329biological_processcell junction assembly
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035385biological_processRoundabout signaling pathway
A0036089biological_processcleavage furrow formation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042476biological_processodontogenesis
A0042995cellular_componentcell projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043149biological_processstress fiber assembly
A0043197cellular_componentdendritic spine
A0043296cellular_componentapical junction complex
A0043297biological_processapical junction assembly
A0043366biological_processbeta selection
A0043542biological_processendothelial cell migration
A0043547biological_processpositive regulation of GTPase activity
A0043931biological_processossification involved in bone maturation
A0044319biological_processwound healing, spreading of cells
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045666biological_processpositive regulation of neuron differentiation
A0045792biological_processnegative regulation of cell size
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0050919biological_processnegative chemotaxis
A0051301biological_processcell division
A0051496biological_processpositive regulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060193biological_processpositive regulation of lipase activity
A0061430biological_processbone trabecula morphogenesis
A0070062cellular_componentextracellular exosome
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071526biological_processsemaphorin-plexin signaling pathway
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090307biological_processmitotic spindle assembly
A0090324biological_processnegative regulation of oxidative phosphorylation
A0097049biological_processmotor neuron apoptotic process
A0097498biological_processendothelial tube lumen extension
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0101003cellular_componentficolin-1-rich granule membrane
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1902766biological_processskeletal muscle satellite cell migration
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903673biological_processmitotic cleavage furrow formation
A1904695biological_processpositive regulation of vascular associated smooth muscle contraction
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A1990869biological_processcellular response to chemokine
A2000177biological_processregulation of neural precursor cell proliferation
A2000406biological_processpositive regulation of T cell migration
A2000672biological_processnegative regulation of motor neuron apoptotic process
B0000902biological_processcell morphogenesis
B0001764biological_processneuron migration
B0001822biological_processkidney development
B0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
B0002363biological_processalpha-beta T cell lineage commitment
B0003100biological_processregulation of systemic arterial blood pressure by endothelin
B0003189biological_processaortic valve formation
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005096molecular_functionGTPase activator activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006357biological_processregulation of transcription by RNA polymerase II
B0007010biological_processcytoskeleton organization
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007165biological_processsignal transduction
B0007266biological_processRho protein signal transduction
B0007519biological_processskeletal muscle tissue development
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010812biological_processnegative regulation of cell-substrate adhesion
B0010975biological_processregulation of neuron projection development
B0016477biological_processcell migration
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0021795biological_processcerebral cortex cell migration
B0021861biological_processforebrain radial glial cell differentiation
B0030027cellular_componentlamellipodium
B0030036biological_processactin cytoskeleton organization
B0030054cellular_componentcell junction
B0030154biological_processcell differentiation
B0030334biological_processregulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030521biological_processandrogen receptor signaling pathway
B0030667cellular_componentsecretory granule membrane
B0031122biological_processcytoplasmic microtubule organization
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032467biological_processpositive regulation of cytokinesis
B0032587cellular_componentruffle membrane
B0032956biological_processregulation of actin cytoskeleton organization
B0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
B0033688biological_processregulation of osteoblast proliferation
B0034329biological_processcell junction assembly
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035385biological_processRoundabout signaling pathway
B0036089biological_processcleavage furrow formation
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0042476biological_processodontogenesis
B0042995cellular_componentcell projection
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043296cellular_componentapical junction complex
B0043297biological_processapical junction assembly
B0043366biological_processbeta selection
B0043542biological_processendothelial cell migration
B0043547biological_processpositive regulation of GTPase activity
B0043931biological_processossification involved in bone maturation
B0044319biological_processwound healing, spreading of cells
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045666biological_processpositive regulation of neuron differentiation
B0045792biological_processnegative regulation of cell size
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0050919biological_processnegative chemotaxis
B0051301biological_processcell division
B0051496biological_processpositive regulation of stress fiber assembly
B0051893biological_processregulation of focal adhesion assembly
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060193biological_processpositive regulation of lipase activity
B0061430biological_processbone trabecula morphogenesis
B0070062cellular_componentextracellular exosome
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071222biological_processcellular response to lipopolysaccharide
B0071345biological_processcellular response to cytokine stimulus
B0071526biological_processsemaphorin-plexin signaling pathway
B0071803biological_processpositive regulation of podosome assembly
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0071944cellular_componentcell periphery
B0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
B0090307biological_processmitotic spindle assembly
B0090324biological_processnegative regulation of oxidative phosphorylation
B0097049biological_processmotor neuron apoptotic process
B0097498biological_processendothelial tube lumen extension
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0101003cellular_componentficolin-1-rich granule membrane
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1902766biological_processskeletal muscle satellite cell migration
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903673biological_processmitotic cleavage furrow formation
B1904695biological_processpositive regulation of vascular associated smooth muscle contraction
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
B1990869biological_processcellular response to chemokine
B2000177biological_processregulation of neural precursor cell proliferation
B2000406biological_processpositive regulation of T cell migration
B2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue GDP B 1201
ChainResidue
BALA15
BSER160
BALA161
BLYS162
BARG942
BMG1202
BALF1203
BHOH1312
BHOH1320
BHOH1388
BCYS16
BGLY17
BLYS18
BTHR19
BCYS20
BLYS118
BASP120
BLEU121

site_idAC2
Number of Residues5
Detailsbinding site for residue MG B 1202
ChainResidue
BTHR19
BGDP1201
BALF1203
BHOH1312
BHOH1320

site_idAC3
Number of Residues11
Detailsbinding site for residue ALF B 1203
ChainResidue
BGLY14
BALA15
BLYS18
BGLY62
BGLN63
BARG942
BGDP1201
BMG1202
BHOH1304
BHOH1312
BHOH1320

site_idAC4
Number of Residues19
Detailsbinding site for residue GDP A 1201
ChainResidue
AALA15
ACYS16
AGLY17
ALYS18
ATHR19
ACYS20
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
AARG942
AMG1202
AALF1203
AHOH1307
AHOH1323
AHOH1353
AHOH1365

site_idAC5
Number of Residues5
Detailsbinding site for residue MG A 1202
ChainResidue
ATHR19
AGDP1201
AALF1203
AHOH1307
AHOH1323

site_idAC6
Number of Residues11
Detailsbinding site for residue ALF A 1203
ChainResidue
AGLY14
AALA15
ALYS18
AGLY62
AGLN63
AARG942
AGDP1201
AMG1202
AHOH1305
AHOH1307
AHOH1323

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
BGLY12
BASN117
AGLY12
AASN117

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
BPHE30
BASP59
BSER160
APHE30
AASP59
ASER160

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
BTYR34
ATYR34

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
BTHR37
ATHR37

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
BASN41
AASN41

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
BGLN63
AGLN63

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
BTYR34
ATYR34

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
BTHR37
ATHR37

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
BLYS135
ALYS135

226707

PDB entries from 2024-10-30

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