5J0A
Crystal structure of PDZ-binding kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004708 | molecular_function | MAP kinase kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004708 | molecular_function | MAP kinase kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | SER76 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG81 |
| A | GLY188 |
| A | VAL189 |
| A | SER190 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS176 |
| A | GLY177 |
| A | TYR117 |
| A | GLY119 |
| A | GLU120 |
| A | ILE175 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | ARG130 |
| A | PRO139 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | HIS94 |
| A | ARG152 |
| A | VAL315 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue HC4 A 406 |
| Chain | Residue |
| A | LYS65 |
| A | ILE66 |
| A | ASN67 |
| A | PRO68 |
| A | HOH521 |
| B | THR209 |
| B | GLU210 |
| B | TYR272 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue HC4 A 407 |
| Chain | Residue |
| A | TYR78 |
| A | ARG101 |
| A | GLU116 |
| A | TYR117 |
| B | TYR78 |
| B | ARG101 |
| B | PHE103 |
| B | LYS306 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue HC4 A 408 |
| Chain | Residue |
| A | THR209 |
| A | GLU210 |
| A | TYR272 |
| A | HOH505 |
| B | LYS65 |
| B | ILE66 |
| B | ASN67 |
| B | PRO68 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | ARG81 |
| B | GLY188 |
| B | VAL189 |
| B | SER190 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| A | SER76 |
| A | GLN79 |
| B | HIS73 |
| B | SER76 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ILE69 |
| B | ARG75 |
| B | GLN79 |
| B | LYS80 |
| B | HOH530 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | HIS93 |
| B | HIS94 |
| B | PRO95 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ARG278 |
| B | ASN302 |
| B | GLU303 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue HC4 B 406 |
| Chain | Residue |
| B | LYS90 |
| B | ARG101 |
| B | ALA102 |
| B | THR104 |
| B | GLU105 |
| B | GLU219 |
| B | ASP304 |
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHgDIKssNVVI |
| Chain | Residue | Details |
| B | LEU163-ILE175 | |
| A | LEU163-ILE175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
