5IOR
Flavin-dependent thymidylate synthase in complex with FAD and 2'-deoxyuridine-5'-monosulfate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0032259 | biological_process | methylation |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050797 | molecular_function | thymidylate synthase (FAD) activity |
A | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | binding site for residue FAD A 301 |
Chain | Residue |
A | THR55 |
A | SER88 |
A | TYR91 |
A | ASN163 |
A | ARG165 |
A | ASN169 |
A | LEU173 |
A | ARG174 |
A | HIS178 |
A | DUS302 |
A | RBF303 |
A | GLU58 |
A | HOH406 |
A | HOH409 |
A | HOH414 |
A | HOH423 |
A | HOH464 |
A | HOH467 |
A | HOH474 |
A | HOH475 |
A | HOH479 |
A | ARG78 |
A | HIS79 |
A | ARG80 |
A | ILE81 |
A | ILE81 |
A | ASN85 |
A | GLU86 |
site_id | AC2 |
Number of Residues | 14 |
Details | binding site for residue DUS A 302 |
Chain | Residue |
A | ARG74 |
A | GLN75 |
A | ARG78 |
A | GLU86 |
A | LEU87 |
A | SER88 |
A | GLY89 |
A | ARG90 |
A | ARG147 |
A | ARG174 |
A | FAD301 |
A | HOH417 |
A | HOH455 |
A | HOH456 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue RBF A 303 |
Chain | Residue |
A | ARG40 |
A | TYR47 |
A | HIS53 |
A | THR55 |
A | ASN85 |
A | TYR91 |
A | FAD301 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Involved in ionization of N3 of dUMP, leading to its activation => ECO:0000269|PubMed:27214228 |
Chain | Residue | Details |
A | ARG174 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW |
Chain | Residue | Details |
A | THR55 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS |
Chain | Residue | Details |
A | GLN75 | |
A | ARG174 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12211025, ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0000269|PubMed:34315871, ECO:0007744|PDB:1KQ4, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GTD, ECO:0007744|PDB:4KAS, ECO:0007744|PDB:7NDW |
Chain | Residue | Details |
A | ARG78 | |
A | GLU86 | |
A | ASN163 | |
A | ASN169 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: in other chain => ECO:0000269|PubMed:12791256, ECO:0000269|PubMed:19370033, ECO:0000269|PubMed:22477781, ECO:0000269|PubMed:23019356, ECO:0000269|PubMed:24563811, ECO:0000269|PubMed:27214228, ECO:0007744|PDB:1O26, ECO:0007744|PDB:3G4A, ECO:0007744|PDB:3N0B, ECO:0007744|PDB:4GT9, ECO:0007744|PDB:4KAS |
Chain | Residue | Details |
A | ARG147 |