5INK
Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | PHE209 |
| A | PRO210 |
| A | ASN211 |
| A | GLU246 |
| A | ARG249 |
| A | THR253 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | HOH538 |
| D | 3DR1 |
| D | HOH109 |
| A | GLU162 |
| A | HOH519 |
| A | HOH534 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | GLU162 |
| B | HOH523 |
| B | HOH528 |
| B | HOH531 |
| C | 3DR1 |
| C | HOH107 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EPE B 402 |
| Chain | Residue |
| B | CYS149 |
| B | TYR153 |
| B | VAL345 |
| B | GLY346 |
| B | LEU347 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 403 |
| Chain | Residue |
| A | PRO208 |
| B | ILE180 |
| B | ILE181 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | binding site for Di-nucleotide 3DR C 1 and DC C 2 |
| Chain | Residue |
| B | ASN130 |
| B | GLU162 |
| B | HIS236 |
| B | SER239 |
| B | THR240 |
| B | ASP272 |
| B | ASN274 |
| B | ARG276 |
| B | TRP307 |
| B | ILE317 |
| B | TYR321 |
| B | PHE325 |
| B | HIS359 |
| B | MG401 |
| B | HOH528 |
| B | HOH531 |
| C | DG3 |
| C | HOH101 |
| C | HOH102 |
| C | HOH103 |
| C | HOH105 |
| C | HOH107 |
| C | HOH109 |
| D | DC8 |
| D | DG9 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for Di-nucleotide 3DR D 1 and DC D 2 |
| Chain | Residue |
| A | ASN130 |
| A | GLU162 |
| A | HIS236 |
| A | SER239 |
| A | THR240 |
| A | ASP272 |
| A | ASN274 |
| A | ARG276 |
| A | TRP307 |
| A | ILE317 |
| A | TYR321 |
| A | HIS323 |
| A | HIS359 |
| A | MG402 |
| A | HOH519 |
| A | HOH534 |
| C | DC8 |
| C | DG9 |
| D | DG3 |
| D | HOH101 |
| D | HOH102 |
| D | HOH107 |
| D | HOH109 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23104055, ECO:0000305|PubMed:27060144 |
| Chain | Residue | Details |
| A | ASP272 | |
| B | ASP272 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | ASP132 | |
| B | ASP132 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27099339, ECO:0007744|PDB:4GYZ, ECO:0007744|PDB:4GZ1, ECO:0007744|PDB:4GZ2, ECO:0007744|PDB:4PUQ, ECO:0007744|PDB:5HT2, ECO:0007744|PDB:5INP, ECO:0007744|PDB:5J42 |
| Chain | Residue | Details |
| A | GLU162 | |
| B | GLU162 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TYR188 | |
| B | TYR188 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055, ECO:0000269|PubMed:24808172, ECO:0000269|PubMed:27060144 |
| Chain | Residue | Details |
| A | TRP307 | |
| A | HIS359 | |
| B | TRP307 | |
| B | HIS359 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000269|PubMed:23104055 |
| Chain | Residue | Details |
| A | PHE325 | |
| B | PHE325 |
