5INK

Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 401

Chain	Residue
A	PHE209
A	PRO210
A	ASN211
A	GLU246
A	ARG249
A	THR253

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	HOH538
D	3DR1
D	HOH109
A	GLU162
A	HOH519
A	HOH534

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG B 401

Chain	Residue
B	GLU162
B	HOH523
B	HOH528
B	HOH531
C	3DR1
C	HOH107

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EPE B 402

Chain	Residue
B	CYS149
B	TYR153
B	VAL345
B	GLY346
B	LEU347

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PEG B 403

Chain	Residue
A	PRO208
B	ILE180
B	ILE181

---

site_id	AC6
Number of Residues	25
Details	binding site for Di-nucleotide 3DR C 1 and DC C 2

Chain	Residue
B	ASN130
B	GLU162
B	HIS236
B	SER239
B	THR240
B	ASP272
B	ASN274
B	ARG276
B	TRP307
B	ILE317
B	TYR321
B	PHE325
B	HIS359
B	MG401
B	HOH528
B	HOH531
C	DG3
C	HOH101
C	HOH102
C	HOH103
C	HOH105
C	HOH107
C	HOH109
D	DC8
D	DG9

---

site_id	AC7
Number of Residues	23
Details	binding site for Di-nucleotide 3DR D 1 and DC D 2

Chain	Residue
A	ASN130
A	GLU162
A	HIS236
A	SER239
A	THR240
A	ASP272
A	ASN274
A	ARG276
A	TRP307
A	ILE317
A	TYR321
A	HIS323
A	HIS359
A	MG402
A	HOH519
A	HOH534
C	DC8
C	DG9
D	DG3
D	HOH101
D	HOH102
D	HOH107
D	HOH109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	26
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27099339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27099339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---