5IL0
Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 601 |
| Chain | Residue |
| A | TRP373 |
| A | PRO537 |
| A | LEU551 |
| A | ASP552 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| B | HOH613 |
| A | ARG468 |
| B | ARG142 |
| B | ASP310 |
| B | ILE311 |
| B | GLU329 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue BR B 502 |
| Chain | Residue |
| B | ASP222 |
| B | ARG249 |
| B | LYS250 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
| Chain | Residue | Details |
| B | TYR146 | |
| B | ASP242 | |
| B | ARG245 | |
| B | ARG298 | |
| B | SEP399 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:29348140, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SEP399 | |
| A | LYS513 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
| Chain | Residue | Details |
| A | GLU438 | |
| A | ARG441 |
