5IFS
Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue ADP B 501 |
| Chain | Residue |
| B | ASP205 |
| B | HIS384 |
| B | GLY408 |
| B | ALA409 |
| B | MG502 |
| B | HOH656 |
| B | HOH661 |
| B | GLY207 |
| B | GLY248 |
| B | THR249 |
| B | GLY250 |
| B | LYS251 |
| B | THR252 |
| B | LEU253 |
| B | ILE380 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| B | ADP501 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | ARG359 |
| B | ARG362 |
| B | HOH699 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | ARG147 |
| B | LYS148 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ASN36 |
| B | LEU153 |
| B | VAL154 |
| B | ARG155 |
| B | HOH660 |
| B | HOH723 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | THR180 |
| B | ILE182 |
| B | HOH685 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue ADP D 501 |
| Chain | Residue |
| D | ASP205 |
| D | GLY207 |
| D | GLY248 |
| D | THR249 |
| D | GLY250 |
| D | LYS251 |
| D | THR252 |
| D | LEU253 |
| D | ILE380 |
| D | HIS384 |
| D | GLY408 |
| D | ALA409 |
| D | MG502 |
| D | HOH629 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue MG D 502 |
| Chain | Residue |
| D | ADP501 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| D | GLN398 |
| D | HOH616 |
Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R |
| Chain | Residue | Details |
| B | VAL341-ARG359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 152 |
| Details | Domain: {"description":"UBX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00215","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | Region: {"description":"Interaction with GLUT4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20512113","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine; by VCPKMT","evidences":[{"source":"PubMed","id":"22948820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23349634","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
