5IC1

Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0007155	biological_process	cell adhesion
A	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 1901

Chain	Residue
A	GLN1466
A	SER1508
A	HOH2012
A	HOH2016

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 1902

Chain	Residue
A	SER1694
A	GLN1695
A	LYS1751

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 1903

Chain	Residue
A	SER1641
A	ILE1644
A	SER1400
A	GLY1404

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Region: {"description":"Helical bundle R7A; Interaction with KANK1","evidences":[{"source":"PubMed","id":"27410476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23389036","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	300
Details	Region: {"description":"Interaction with VCL and F-actin","evidences":[{"source":"PubMed","id":"20610383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	119
Details	Region: {"description":"Helical bundle R8","evidences":[{"source":"PubMed","id":"23389036","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	72
Details	Region: {"description":"Helical bundle R7B; Interaction with KANK1","evidences":[{"source":"PubMed","id":"27410476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23389036","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---