Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5I2D

Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005737	cellular_component	cytoplasm
F	0006352	biological_process	DNA-templated transcription initiation
F	0006355	biological_process	regulation of DNA-templated transcription
F	0010468	biological_process	regulation of gene expression
F	0016987	molecular_function	sigma factor activity
F	0046872	molecular_function	metal ion binding
F	2000142	biological_process	regulation of DNA-templated transcription initiation
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0042803	molecular_function	protein homodimerization activity
H	0003677	molecular_function	DNA binding
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0042803	molecular_function	protein homodimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006351	biological_process	DNA-templated transcription
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0046983	molecular_function	protein dimerization activity
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed RNA polymerase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0006351	biological_process	DNA-templated transcription
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034062	molecular_function	5'-3' RNA polymerase activity
M	0046983	molecular_function	protein dimerization activity
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed RNA polymerase activity
N	0006351	biological_process	DNA-templated transcription
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0032549	molecular_function	ribonucleoside binding
N	0034062	molecular_function	5'-3' RNA polymerase activity
O	0000287	molecular_function	magnesium ion binding
O	0000428	cellular_component	DNA-directed RNA polymerase complex
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed RNA polymerase activity
O	0005515	molecular_function	protein binding
O	0006351	biological_process	DNA-templated transcription
O	0008270	molecular_function	zinc ion binding
O	0016740	molecular_function	transferase activity
O	0016779	molecular_function	nucleotidyltransferase activity
O	0034062	molecular_function	5'-3' RNA polymerase activity
O	0046872	molecular_function	metal ion binding
P	0000428	cellular_component	DNA-directed RNA polymerase complex
P	0003677	molecular_function	DNA binding
P	0003899	molecular_function	DNA-directed RNA polymerase activity
P	0006351	biological_process	DNA-templated transcription
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0034062	molecular_function	5'-3' RNA polymerase activity
Q	0003677	molecular_function	DNA binding
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0005737	cellular_component	cytoplasm
Q	0006352	biological_process	DNA-templated transcription initiation
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0010468	biological_process	regulation of gene expression
Q	0016987	molecular_function	sigma factor activity
Q	0046872	molecular_function	metal ion binding
Q	2000142	biological_process	regulation of DNA-templated transcription initiation
R	0003677	molecular_function	DNA binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0005515	molecular_function	protein binding
R	0005829	cellular_component	cytosol
R	0006355	biological_process	regulation of DNA-templated transcription
R	0042803	molecular_function	protein homodimerization activity
S	0003677	molecular_function	DNA binding
S	0003700	molecular_function	DNA-binding transcription factor activity
S	0005515	molecular_function	protein binding
S	0005829	cellular_component	cytosol
S	0006355	biological_process	regulation of DNA-templated transcription
S	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN D 2001

Chain	Residue
D	CYS1112
D	CYS1194
D	CYS1201
D	CYS1204

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 2002

Chain	Residue
D	CYS58
D	CYS60
D	CYS73
D	CYS76

site_id	AC3
Number of Residues	4
Details	binding site for residue MG D 2003

Chain	Residue
D	ASP741
D	ASP743
K	A4
D	ASP739

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN O 2001

Chain	Residue
O	CYS1112
O	CYS1194
O	CYS1201
O	CYS1204

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN O 2002

Chain	Residue
O	CYS58
O	CYS60
O	CYS73
O	CYS76

site_id	AC6
Number of Residues	4
Details	binding site for residue MG O 2003

Chain	Residue
O	ASP739
O	ASP741
O	ASP743
V	A4

Functional Information from PROSITE/UniProt

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TleEVGaffgVTrerIrQIEnkaLrkL

Chain	Residue	Details
F	THR382-LEU408

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL

Chain	Residue	Details
F	LEU187-LEU194

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV

Chain	Residue	Details
C	GLY836-VAL848

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255\|PROSITE-ProRule:PRU00387

Chain	Residue	Details
G	HIS142-ALA161
D	CYS1201
D	CYS1204
O	CYS58
O	CYS60
O	CYS73
O	CYS76
O	ASP739
O	ASP741
O	ASP743
O	CYS1112
H	HIS142-ALA161
O	CYS1194
O	CYS1201
O	CYS1204
R	HIS142-ALA161
S	HIS142-ALA161
D	ASP739
D	ASP741
D	ASP743
D	CYS1112
D	CYS1194

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)