5HPE

Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MN A 1101

Chain	Residue
A	ASP271
A	ASN303
A	HIS352
A	HIS427
A	GLU1013
A	MN1102
A	HOH1203

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site_id	AC2
Number of Residues	7
Details	binding site for residue MN A 1102

Chain	Residue
A	ASP271
A	GLU1013
A	MN1101
A	HOH1203
A	HOH1257
A	ASP242
A	HIS244

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NCO A 1103

Chain	Residue
A	GLU255
A	LEU256
A	GLY258
A	GLU336
A	ASN372
A	HOH1235

---

site_id	AC4
Number of Residues	5
Details	binding site for residue NCO A 1104

Chain	Residue
A	LYS320
A	ALA321
A	LYS322
A	TYR323
A	TRP511

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Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU300-GLU305

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:15155720

Chain	Residue	Details
A	HIS304

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64

Chain	Residue	Details
A	ASP271
A	ASN303
A	HIS352
A	ASP242

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15155720

Chain	Residue	Details
A	ARG275
A	ARG400
A	HIS427
A	HIS244

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	GLU1013

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	10
Details	M-CSA 472

Chain	Residue	Details
A	ASP242	metal ligand
A	HIS244	metal ligand
A	ASP271	metal ligand
A	ASP274	activator, proton donor
A	ARG275	transition state stabiliser
A	ASN303	metal ligand, transition state stabiliser
A	HIS304	proton acceptor, proton donor, proton relay
A	HIS352	metal ligand
A	ARG400	transition state stabiliser
A	HIS427	activator, metal ligand

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