5HK5

Structure of the Grem2-GDF5 Inhibitory Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0005576	cellular_component	extracellular region
C	0008083	molecular_function	growth factor activity
D	0005576	cellular_component	extracellular region
D	0008083	molecular_function	growth factor activity
E	0005125	molecular_function	cytokine activity
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0008201	molecular_function	heparin binding
E	0009966	biological_process	regulation of signal transduction
E	0010172	biological_process	embryonic body morphogenesis
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0030514	biological_process	negative regulation of BMP signaling pathway
E	0036122	molecular_function	BMP binding
E	0038098	biological_process	sequestering of BMP from receptor via BMP binding
E	0042802	molecular_function	identical protein binding
E	0048018	molecular_function	receptor ligand activity
E	0048263	biological_process	determination of dorsal identity
E	0060300	biological_process	regulation of cytokine activity
F	0005125	molecular_function	cytokine activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0008201	molecular_function	heparin binding
F	0009966	biological_process	regulation of signal transduction
F	0010172	biological_process	embryonic body morphogenesis
F	0019221	biological_process	cytokine-mediated signaling pathway
F	0030514	biological_process	negative regulation of BMP signaling pathway
F	0036122	molecular_function	BMP binding
F	0038098	biological_process	sequestering of BMP from receptor via BMP binding
F	0042802	molecular_function	identical protein binding
F	0048018	molecular_function	receptor ligand activity
F	0048263	biological_process	determination of dorsal identity
F	0060300	biological_process	regulation of cytokine activity
G	0005125	molecular_function	cytokine activity
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0008201	molecular_function	heparin binding
G	0009966	biological_process	regulation of signal transduction
G	0010172	biological_process	embryonic body morphogenesis
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0030514	biological_process	negative regulation of BMP signaling pathway
G	0036122	molecular_function	BMP binding
G	0038098	biological_process	sequestering of BMP from receptor via BMP binding
G	0042802	molecular_function	identical protein binding
G	0048018	molecular_function	receptor ligand activity
G	0048263	biological_process	determination of dorsal identity
G	0060300	biological_process	regulation of cytokine activity
H	0005125	molecular_function	cytokine activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0008201	molecular_function	heparin binding
H	0009966	biological_process	regulation of signal transduction
H	0010172	biological_process	embryonic body morphogenesis
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0030514	biological_process	negative regulation of BMP signaling pathway
H	0036122	molecular_function	BMP binding
H	0038098	biological_process	sequestering of BMP from receptor via BMP binding
H	0042802	molecular_function	identical protein binding
H	0048018	molecular_function	receptor ligand activity
H	0048263	biological_process	determination of dorsal identity
H	0060300	biological_process	regulation of cytokine activity

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPleYeafhCeGlC

Chain	Residue	Details
A	ILE37-CYS52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Domain: {"description":"CTCK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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