5H9E

Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0008270	molecular_function	zinc ion binding
A	0032991	cellular_component	protein-containing complex
A	0051607	biological_process	defense response to virus
A	0099048	biological_process	CRISPR-cas system
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0032991	cellular_component	protein-containing complex
B	0051607	biological_process	defense response to virus
B	0099048	biological_process	CRISPR-cas system
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0032991	cellular_component	protein-containing complex
C	0051607	biological_process	defense response to virus
C	0099048	biological_process	CRISPR-cas system
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0032991	cellular_component	protein-containing complex
D	0051607	biological_process	defense response to virus
D	0071667	molecular_function	DNA/RNA hybrid binding
D	0099048	biological_process	CRISPR-cas system
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0032991	cellular_component	protein-containing complex
E	0051607	biological_process	defense response to virus
E	0071667	molecular_function	DNA/RNA hybrid binding
E	0099048	biological_process	CRISPR-cas system
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0032991	cellular_component	protein-containing complex
F	0051607	biological_process	defense response to virus
F	0071667	molecular_function	DNA/RNA hybrid binding
F	0099048	biological_process	CRISPR-cas system
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0032991	cellular_component	protein-containing complex
G	0051607	biological_process	defense response to virus
G	0071667	molecular_function	DNA/RNA hybrid binding
G	0099048	biological_process	CRISPR-cas system
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0032991	cellular_component	protein-containing complex
H	0051607	biological_process	defense response to virus
H	0071667	molecular_function	DNA/RNA hybrid binding
H	0099048	biological_process	CRISPR-cas system
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0032991	cellular_component	protein-containing complex
I	0051607	biological_process	defense response to virus
I	0071667	molecular_function	DNA/RNA hybrid binding
I	0099048	biological_process	CRISPR-cas system
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0032991	cellular_component	protein-containing complex
J	0043571	biological_process	maintenance of CRISPR repeat elements
J	0051607	biological_process	defense response to virus
J	0071667	molecular_function	DNA/RNA hybrid binding
J	0099048	biological_process	CRISPR-cas system
K	0003723	molecular_function	RNA binding
K	0004518	molecular_function	nuclease activity
K	0004519	molecular_function	endonuclease activity
K	0004521	molecular_function	RNA endonuclease activity
K	0005515	molecular_function	protein binding
K	0006396	biological_process	RNA processing
K	0016787	molecular_function	hydrolase activity
K	0032991	cellular_component	protein-containing complex
K	0051607	biological_process	defense response to virus
K	0099048	biological_process	CRISPR-cas system

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 601

Chain	Residue
A	CYS140
A	CYS143
A	CYS250
A	CYS253

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site_id	AC2
Number of Residues	6
Details	binding site for Di-nucleotide G L 60 and 23G L 61

Chain	Residue
L	G59
K	ASP36
K	GLN181
L	C46
L	C47
L	C48

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