Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue D16 A 401 |
| Chain | Residue |
| A | PHE104 |
| A | ASP242 |
| A | LEU245 |
| A | GLY246 |
| A | PHE249 |
| A | UMP402 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue UMP A 402 |
| Chain | Residue |
| A | SER240 |
| A | GLY241 |
| A | ASP242 |
| A | GLY246 |
| A | ASN250 |
| A | HIS280 |
| A | TYR282 |
| A | D16401 |
| B | ARG199 |
| B | ARG200 |
| A | CYS219 |
| A | HIS220 |
| A | ARG239 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue D16 B 401 |
| Chain | Residue |
| B | ASP242 |
| B | LEU245 |
| B | GLY246 |
| B | PHE249 |
| B | UMP402 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue UMP B 402 |
| Chain | Residue |
| A | ARG199 |
| A | ARG200 |
| B | CYS219 |
| B | HIS220 |
| B | GLN238 |
| B | ARG239 |
| B | SER240 |
| B | GLY241 |
| B | ASP242 |
| B | GLY246 |
| B | ASN250 |
| B | HIS280 |
| B | TYR282 |
| B | D16401 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImcaWNpadlslma.....LpPCHllcQFyV |
| Chain | Residue | Details |
| A | ARG199-VAL227 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS219 | |
| B | CYS219 | |
| Chain | Residue | Details |
| A | ARG74 | |
| A | ARG239 | |
| A | ASN250 | |
| A | HIS280 | |
| B | ARG74 | |
| B | ARG239 | |
| B | ASN250 | |
| B | HIS280 | |
| Chain | Residue | Details |
| A | ARG199 | |
| A | ASP242 | |
| B | ARG199 | |
| B | ASP242 | |
