5GWZ
The structure of Porcine epidemic diarrhea virus main protease in complex with an inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN D OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| A | HIS235 |
| B | LEU164 |
| B | GLU165 |
| B | HIS171 |
| B | GLN187 |
| B | PRO188 |
| B | THR189 |
| B | LEU190 |
| B | GLN191 |
| B | HOH430 |
| D | HOH101 |
| B | MET25 |
| B | ALA26 |
| B | HIS41 |
| B | PHE139 |
| B | GLY142 |
| B | CYS144 |
| B | HIS162 |
| B | GLN163 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR CHAIN E OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| A | MET25 |
| A | LEU27 |
| A | HIS41 |
| A | PHE139 |
| A | ASN141 |
| A | GLY142 |
| A | CYS144 |
| A | HIS162 |
| A | GLN163 |
| A | LEU164 |
| A | GLU165 |
| A | HIS171 |
| A | GLN187 |
| A | PRO188 |
| A | THR189 |
| A | LEU190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27173881","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
