5GWT

4-hydroxyisoleucine dehydrogenase mutant complexed with NADH and succinate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	35
Details	binding site for residue NAD A 301

Chain	Residue
A	GLY11
A	LEU58
A	LYS75
A	ALA84
A	ALA85
A	GLY86
A	ILE87
A	VAL107
A	ILE135
A	ALA136
A	SER137
A	ASN13
A	TYR150
A	LYS154
A	PRO180
A	GLY181
A	ILE183
A	THR185
A	LEU187
A	THR188
A	SIN302
A	HOH430
A	SER14
A	HOH431
A	HOH432
A	HOH436
A	HOH452
A	HOH453
A	HOH491
A	GLY15
A	ILE16
A	ASP35
A	ILE36
A	ILE56
A	ASP57

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SIN A 302

Chain	Residue
A	ARG88
A	SER137
A	VAL138
A	SER139
A	LYS144
A	ARG147
A	TYR150
A	TYR191
A	NAD301
A	HOH453

---

site_id	AC3
Number of Residues	35
Details	binding site for residue NAD B 301

Chain	Residue
B	GLY11
B	SER14
B	GLY15
B	ILE16
B	ASP35
B	ILE36
B	ASN37
B	ILE56
B	ASP57
B	LEU58
B	ALA84
B	ALA85
B	GLY86
B	ILE87
B	VAL107
B	ILE135
B	ALA136
B	SER137
B	TYR150
B	LYS154
B	PRO180
B	GLY181
B	ILE183
B	THR185
B	LEU187
B	THR188
B	SIN302
B	HOH410
B	HOH411
B	HOH416
B	HOH434
B	HOH442
B	HOH469
B	HOH471
B	HOH483

---

site_id	AC4
Number of Residues	10
Details	binding site for residue SIN B 302

Chain	Residue
B	ARG88
B	SER137
B	VAL138
B	SER139
B	LYS144
B	ARG147
B	TYR150
B	TYR191
B	NAD301
B	HOH434

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SIN C 301

Chain	Residue
C	HOH417
C	ARG88
C	SER137
C	VAL138
C	SER139
C	LYS144
C	ARG147
C	TYR150
C	TYR191
C	NAD302

---

site_id	AC6
Number of Residues	34
Details	binding site for residue NAD C 302

Chain	Residue
C	GLY11
C	SER14
C	GLY15
C	ILE16
C	ASP35
C	ILE36
C	ASN37
C	ILE56
C	ASP57
C	LEU58
C	ALA84
C	ALA85
C	GLY86
C	ILE87
C	VAL107
C	ILE135
C	ALA136
C	SER137
C	TYR150
C	LYS154
C	PRO180
C	GLY181
C	ILE183
C	THR185
C	LEU187
C	THR188
C	SIN301
C	HOH410
C	HOH417
C	HOH420
C	HOH443
C	HOH448
C	HOH450
C	HOH471

---

site_id	AC7
Number of Residues	11
Details	binding site for residue SIN D 301

Chain	Residue
D	ARG88
D	SER137
D	VAL138
D	SER139
D	LYS144
D	ARG147
D	TYR150
D	TYR191
D	NAD302
D	HOH428
D	HOH466

---

site_id	AC8
Number of Residues	34
Details	binding site for residue NAD D 302

Chain	Residue
D	GLY11
D	ASN13
D	SER14
D	GLY15
D	ILE16
D	ASP35
D	ILE36
D	ASN37
D	ILE56
D	ASP57
D	LEU58
D	ALA84
D	ALA85
D	GLY86
D	ILE87
D	VAL107
D	ILE135
D	ALA136
D	SER137
D	TYR150
D	LYS154
D	PRO180
D	GLY181
D	ILE183
D	THR185
D	LEU187
D	THR188
D	SIN301
D	HOH408
D	HOH412
D	HOH428
D	HOH431
D	HOH434
D	HOH461

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvsglmakpeRaaYVASKHALiGLTkQMA

Chain	Residue	Details
A	SER137-ALA165

---