Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 748 A 1001 |
| Chain | Residue |
| A | LEU599 |
| A | CYS814 |
| A | VAL815 |
| A | HIS816 |
| A | LEU825 |
| A | ILE834 |
| A | CYS835 |
| A | ASP836 |
| A | PHE837 |
| A | HOH1131 |
| A | HOH1235 |
| A | ALA625 |
| A | LYS627 |
| A | GLU644 |
| A | MET648 |
| A | ILE672 |
| A | THR674 |
| A | TYR676 |
| A | CYS677 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1002 |
| Chain | Residue |
| A | PRO918 |
| A | ASP919 |
| A | HOH1394 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1003 |
| Chain | Residue |
| A | LYS623 |
| A | PHE678 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGKVVeGtayglsrsqpvmk.....VAVK |
| Chain | Residue | Details |
| A | LEU599-LYS627 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CVHrDLAARNVLL |
| Chain | Residue | Details |
| A | CYS814-LEU826 | |
| site_id | PS00240 |
| Number of Residues | 14 |
| Details | RECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GpHlNIVNLLGACT |
| Chain | Residue | Details |
| A | GLY652-THR665 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
