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5GJR

An atomic structure of the human 26S proteasome

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
00000166molecular_functionnucleotide binding
00000502cellular_componentproteasome complex
00000932cellular_componentP-body
00005515molecular_functionprotein binding
00005524molecular_functionATP binding
00005576cellular_componentextracellular region
00005634cellular_componentnucleus
00005654cellular_componentnucleoplasm
00005737cellular_componentcytoplasm
00005829cellular_componentcytosol
00006979biological_processresponse to oxidative stress
00008021cellular_componentsynaptic vesicle
00008540cellular_componentproteasome regulatory particle, base subcomplex
00010498biological_processproteasomal protein catabolic process
00016020cellular_componentmembrane
00016887molecular_functionATP hydrolysis activity
00022624cellular_componentproteasome accessory complex
00034774cellular_componentsecretory granule lumen
00036402molecular_functionproteasome-activating activity
00042802molecular_functionidentical protein binding
00043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
00043921biological_processhost-mediated perturbation of viral transcription
00045944biological_processpositive regulation of transcription by RNA polymerase II
00061136biological_processregulation of proteasomal protein catabolic process
00071357biological_processcellular response to type I interferon
01901800biological_processpositive regulation of proteasomal protein catabolic process
01904813cellular_componentficolin-1-rich granule lumen
10000502cellular_componentproteasome complex
10005515molecular_functionprotein binding
10005576cellular_componentextracellular region
10005634cellular_componentnucleus
10005654cellular_componentnucleoplasm
10005829cellular_componentcytosol
10005838cellular_componentproteasome regulatory particle
10006979biological_processresponse to oxidative stress
10008021cellular_componentsynaptic vesicle
10008540cellular_componentproteasome regulatory particle, base subcomplex
10010498biological_processproteasomal protein catabolic process
10016020cellular_componentmembrane
10022624cellular_componentproteasome accessory complex
10030234molecular_functionenzyme regulator activity
10031625molecular_functionubiquitin protein ligase binding
10034515cellular_componentproteasome storage granule
10035578cellular_componentazurophil granule lumen
10042176biological_processregulation of protein catabolic process
10043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
10061136biological_processregulation of proteasomal protein catabolic process
10071357biological_processcellular response to type I interferon
20000502cellular_componentproteasome complex
20005198molecular_functionstructural molecule activity
20005515molecular_functionprotein binding
20005576cellular_componentextracellular region
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005829cellular_componentcytosol
20005838cellular_componentproteasome regulatory particle
20006511biological_processubiquitin-dependent protein catabolic process
20006979biological_processresponse to oxidative stress
20008021cellular_componentsynaptic vesicle
20008541cellular_componentproteasome regulatory particle, lid subcomplex
20010498biological_processproteasomal protein catabolic process
20016020cellular_componentmembrane
20022624cellular_componentproteasome accessory complex
20034774cellular_componentsecretory granule lumen
20043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
20061136biological_processregulation of proteasomal protein catabolic process
20071357biological_processcellular response to type I interferon
21904813cellular_componentficolin-1-rich granule lumen
30000502cellular_componentproteasome complex
30005515molecular_functionprotein binding
30005576cellular_componentextracellular region
30005654cellular_componentnucleoplasm
30005737cellular_componentcytoplasm
30005829cellular_componentcytosol
30005838cellular_componentproteasome regulatory particle
30006979biological_processresponse to oxidative stress
30008021cellular_componentsynaptic vesicle
30008541cellular_componentproteasome regulatory particle, lid subcomplex
30010498biological_processproteasomal protein catabolic process
30016020cellular_componentmembrane
30022624cellular_componentproteasome accessory complex
30034774cellular_componentsecretory granule lumen
30043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
30061136biological_processregulation of proteasomal protein catabolic process
30070062cellular_componentextracellular exosome
30071357biological_processcellular response to type I interferon
31904813cellular_componentficolin-1-rich granule lumen
40000502cellular_componentproteasome complex
40005198molecular_functionstructural molecule activity
40005515molecular_functionprotein binding
40005576cellular_componentextracellular region
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005829cellular_componentcytosol
40005838cellular_componentproteasome regulatory particle
40006511biological_processubiquitin-dependent protein catabolic process
40006979biological_processresponse to oxidative stress
40008021cellular_componentsynaptic vesicle
40008541cellular_componentproteasome regulatory particle, lid subcomplex
40010498biological_processproteasomal protein catabolic process
40016020cellular_componentmembrane
40022624cellular_componentproteasome accessory complex
40032991cellular_componentprotein-containing complex
40034774cellular_componentsecretory granule lumen
40043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
40043248biological_processproteasome assembly
40048863biological_processstem cell differentiation
40061136biological_processregulation of proteasomal protein catabolic process
40071357biological_processcellular response to type I interferon
41904813cellular_componentficolin-1-rich granule lumen
50000502cellular_componentproteasome complex
50005515molecular_functionprotein binding
50005576cellular_componentextracellular region
50005654cellular_componentnucleoplasm
50005829cellular_componentcytosol
50005838cellular_componentproteasome regulatory particle
50006979biological_processresponse to oxidative stress
50008021cellular_componentsynaptic vesicle
50010498biological_processproteasomal protein catabolic process
50022624cellular_componentproteasome accessory complex
50032991cellular_componentprotein-containing complex
50034774cellular_componentsecretory granule lumen
50043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
50061136biological_processregulation of proteasomal protein catabolic process
50071357biological_processcellular response to type I interferon
51904813cellular_componentficolin-1-rich granule lumen
60000502cellular_componentproteasome complex
60005515molecular_functionprotein binding
60005576cellular_componentextracellular region
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005829cellular_componentcytosol
60005838cellular_componentproteasome regulatory particle
60006511biological_processubiquitin-dependent protein catabolic process
60006979biological_processresponse to oxidative stress
60008021cellular_componentsynaptic vesicle
60008541cellular_componentproteasome regulatory particle, lid subcomplex
60010498biological_processproteasomal protein catabolic process
60016020cellular_componentmembrane
60022624cellular_componentproteasome accessory complex
60030234molecular_functionenzyme regulator activity
60034774cellular_componentsecretory granule lumen
60042176biological_processregulation of protein catabolic process
60043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
60061136biological_processregulation of proteasomal protein catabolic process
60070062cellular_componentextracellular exosome
60071357biological_processcellular response to type I interferon
61904813cellular_componentficolin-1-rich granule lumen
70000502cellular_componentproteasome complex
70005515molecular_functionprotein binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005829cellular_componentcytosol
70005838cellular_componentproteasome regulatory particle
70006508biological_processproteolysis
70006979biological_processresponse to oxidative stress
70008021cellular_componentsynaptic vesicle
70008541cellular_componentproteasome regulatory particle, lid subcomplex
70010498biological_processproteasomal protein catabolic process
70022624cellular_componentproteasome accessory complex
70032991cellular_componentprotein-containing complex
70043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
70061136biological_processregulation of proteasomal protein catabolic process
70071357biological_processcellular response to type I interferon
80000502cellular_componentproteasome complex
80005515molecular_functionprotein binding
80005576cellular_componentextracellular region
80005634cellular_componentnucleus
80005654cellular_componentnucleoplasm
80005829cellular_componentcytosol
80005838cellular_componentproteasome regulatory particle
80006979biological_processresponse to oxidative stress
80008021cellular_componentsynaptic vesicle
80008233molecular_functionpeptidase activity
80008237molecular_functionmetallopeptidase activity
80010498biological_processproteasomal protein catabolic process
80016020cellular_componentmembrane
80034774cellular_componentsecretory granule lumen
80042803molecular_functionprotein homodimerization activity
80043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
80061136biological_processregulation of proteasomal protein catabolic process
80070062cellular_componentextracellular exosome
80071357biological_processcellular response to type I interferon
80140492molecular_functionmetal-dependent deubiquitinase activity
81904813cellular_componentficolin-1-rich granule lumen
90000502cellular_componentproteasome complex
90000724biological_processdouble-strand break repair via homologous recombination
90004843molecular_functioncysteine-type deubiquitinase activity
90005515molecular_functionprotein binding
90005576cellular_componentextracellular region
90005634cellular_componentnucleus
90005654cellular_componentnucleoplasm
90005829cellular_componentcytosol
90006281biological_processDNA repair
90006303biological_processdouble-strand break repair via nonhomologous end joining
90006508biological_processproteolysis
90006511biological_processubiquitin-dependent protein catabolic process
90006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
90006914biological_processautophagy
90006974biological_processDNA damage response
90006979biological_processresponse to oxidative stress
90008021cellular_componentsynaptic vesicle
90008233molecular_functionpeptidase activity
90008234molecular_functioncysteine-type peptidase activity
90008237molecular_functionmetallopeptidase activity
90008541cellular_componentproteasome regulatory particle, lid subcomplex
90010498biological_processproteasomal protein catabolic process
90016192biological_processvesicle-mediated transport
90016241biological_processregulation of macroautophagy
90016579biological_processprotein deubiquitination
90016787molecular_functionhydrolase activity
90022624cellular_componentproteasome accessory complex
90031597cellular_componentcytosolic proteasome complex
90034774cellular_componentsecretory granule lumen
90043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
90045471biological_processresponse to ethanol
90046872molecular_functionmetal ion binding
90061133molecular_functionendopeptidase activator activity
90061136biological_processregulation of proteasomal protein catabolic process
90061578molecular_functionK63-linked deubiquitinase activity
90070536biological_processprotein K63-linked deubiquitination
90070628molecular_functionproteasome binding
90071357biological_processcellular response to type I interferon
90140492molecular_functionmetal-dependent deubiquitinase activity
91904813cellular_componentficolin-1-rich granule lumen
a0000502cellular_componentproteasome complex
a0004175molecular_functionendopeptidase activity
a0004298molecular_functionthreonine-type endopeptidase activity
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0005839cellular_componentproteasome core complex
a0006281biological_processDNA repair
a0006508biological_processproteolysis
a0006915biological_processapoptotic process
a0006974biological_processDNA damage response
a0006979biological_processresponse to oxidative stress
a0007283biological_processspermatogenesis
a0008021cellular_componentsynaptic vesicle
a0008233molecular_functionpeptidase activity
a0010498biological_processproteasomal protein catabolic process
a0010499biological_processproteasomal ubiquitin-independent protein catabolic process
a0016787molecular_functionhydrolase activity
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0030317biological_processflagellated sperm motility
a0034515cellular_componentproteasome storage granule
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0045296molecular_functioncadherin binding
a0051321biological_processmeiotic cell cycle
a0051603biological_processobsolete proteolysis involved in protein catabolic process
a0061136biological_processregulation of proteasomal protein catabolic process
a0070062cellular_componentextracellular exosome
a0071357biological_processcellular response to type I interferon
a2000045biological_processregulation of G1/S transition of mitotic cell cycle
AA0000502cellular_componentproteasome complex
AA0003723molecular_functionRNA binding
AA0005515molecular_functionprotein binding
AA0005634cellular_componentnucleus
AA0005829cellular_componentcytosol
AA0006979biological_processresponse to oxidative stress
AA0008021cellular_componentsynaptic vesicle
AA0008540cellular_componentproteasome regulatory particle, base subcomplex
AA0010498biological_processproteasomal protein catabolic process
AA0022624cellular_componentproteasome accessory complex
AA0031593molecular_functionpolyubiquitin modification-dependent protein binding
AA0042802molecular_functionidentical protein binding
AA0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AA0060090molecular_functionmolecular adaptor activity
AA0061136biological_processregulation of proteasomal protein catabolic process
AA0071357biological_processcellular response to type I interferon
AB0000502cellular_componentproteasome complex
AB0005515molecular_functionprotein binding
AB0005634cellular_componentnucleus
AB0005654cellular_componentnucleoplasm
AB0005829cellular_componentcytosol
AB0006406biological_processmRNA export from nucleus
AB0006979biological_processresponse to oxidative stress
AB0008021cellular_componentsynaptic vesicle
AB0008541cellular_componentproteasome regulatory particle, lid subcomplex
AB0010498biological_processproteasomal protein catabolic process
AB0032039cellular_componentintegrator complex
AB0032991cellular_componentprotein-containing complex
AB0043130molecular_functionubiquitin binding
AB0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AB0043248biological_processproteasome assembly
AB0045944biological_processpositive regulation of transcription by RNA polymerase II
AB0061136biological_processregulation of proteasomal protein catabolic process
AB0071357biological_processcellular response to type I interferon
AC0000502cellular_componentproteasome complex
AC0005515molecular_functionprotein binding
AC0005576cellular_componentextracellular region
AC0005634cellular_componentnucleus
AC0005654cellular_componentnucleoplasm
AC0005829cellular_componentcytosol
AC0005838cellular_componentproteasome regulatory particle
AC0006979biological_processresponse to oxidative stress
AC0008021cellular_componentsynaptic vesicle
AC0008540cellular_componentproteasome regulatory particle, base subcomplex
AC0010498biological_processproteasomal protein catabolic process
AC0016020cellular_componentmembrane
AC0022624cellular_componentproteasome accessory complex
AC0030234molecular_functionenzyme regulator activity
AC0034515cellular_componentproteasome storage granule
AC0034774cellular_componentsecretory granule lumen
AC0042176biological_processregulation of protein catabolic process
AC0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
AC0061136biological_processregulation of proteasomal protein catabolic process
AC0070062cellular_componentextracellular exosome
AC0071357biological_processcellular response to type I interferon
AC1904813cellular_componentficolin-1-rich granule lumen
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005576cellular_componentextracellular region
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0005839cellular_componentproteasome core complex
b0006281biological_processDNA repair
b0006508biological_processproteolysis
b0006915biological_processapoptotic process
b0006974biological_processDNA damage response
b0006979biological_processresponse to oxidative stress
b0007283biological_processspermatogenesis
b0008021cellular_componentsynaptic vesicle
b0008233molecular_functionpeptidase activity
b0010498biological_processproteasomal protein catabolic process
b0010499biological_processproteasomal ubiquitin-independent protein catabolic process
b0016604cellular_componentnuclear body
b0016787molecular_functionhydrolase activity
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0030317biological_processflagellated sperm motility
b0034515cellular_componentproteasome storage granule
b0034774cellular_componentsecretory granule lumen
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0051321biological_processmeiotic cell cycle
b0051603biological_processobsolete proteolysis involved in protein catabolic process
b0061136biological_processregulation of proteasomal protein catabolic process
b0071357biological_processcellular response to type I interferon
b1904813cellular_componentficolin-1-rich granule lumen
b2000045biological_processregulation of G1/S transition of mitotic cell cycle
B0000502cellular_componentproteasome complex
B0000932cellular_componentP-body
B0002376biological_processimmune system process
B0003723molecular_functionRNA binding
B0004175molecular_functionendopeptidase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0005840cellular_componentribosome
B0006281biological_processDNA repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007283biological_processspermatogenesis
B0008021cellular_componentsynaptic vesicle
B0010498biological_processproteasomal protein catabolic process
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0016363cellular_componentnuclear matrix
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0030016cellular_componentmyofibril
B0030017cellular_componentsarcomere
B0030317biological_processflagellated sperm motility
B0032729biological_processpositive regulation of type II interferon production
B0032743biological_processpositive regulation of interleukin-2 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0034341biological_processresponse to type II interferon
B0034515cellular_componentproteasome storage granule
B0035639molecular_functionpurine ribonucleoside triphosphate binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043374biological_processCD8-positive, alpha-beta T cell differentiation
B0045061biological_processthymic T cell selection
B0045063biological_processT-helper 1 cell differentiation
B0045590biological_processnegative regulation of regulatory T cell differentiation
B0050727biological_processregulation of inflammatory response
B0051059molecular_functionNF-kappaB binding
B0051321biological_processmeiotic cell cycle
B0051603biological_processobsolete proteolysis involved in protein catabolic process
B0061136biological_processregulation of proteasomal protein catabolic process
B0070062cellular_componentextracellular exosome
B0071357biological_processcellular response to type I interferon
B0072539biological_processT-helper 17 cell differentiation
B0097229cellular_componentsperm end piece
B0097542cellular_componentciliary tip
B0160165biological_processCD8-positive, alpha-beta T cell homeostasis
B2000045biological_processregulation of G1/S transition of mitotic cell cycle
c0000502cellular_componentproteasome complex
c0002376biological_processimmune system process
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0005839cellular_componentproteasome core complex
c0006281biological_processDNA repair
c0006915biological_processapoptotic process
c0006974biological_processDNA damage response
c0006979biological_processresponse to oxidative stress
c0007283biological_processspermatogenesis
c0008021cellular_componentsynaptic vesicle
c0010498biological_processproteasomal protein catabolic process
c0010499biological_processproteasomal ubiquitin-independent protein catabolic process
c0019774cellular_componentproteasome core complex, beta-subunit complex
c0030317biological_processflagellated sperm motility
c0032729biological_processpositive regulation of type II interferon production
c0032743biological_processpositive regulation of interleukin-2 production
c0032760biological_processpositive regulation of tumor necrosis factor production
c0034341biological_processresponse to type II interferon
c0034515cellular_componentproteasome storage granule
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0043374biological_processCD8-positive, alpha-beta T cell differentiation
c0045061biological_processthymic T cell selection
c0045063biological_processT-helper 1 cell differentiation
c0045590biological_processnegative regulation of regulatory T cell differentiation
c0051321biological_processmeiotic cell cycle
c0051603biological_processobsolete proteolysis involved in protein catabolic process
c0061136biological_processregulation of proteasomal protein catabolic process
c0070062cellular_componentextracellular exosome
c0071357biological_processcellular response to type I interferon
c0072539biological_processT-helper 17 cell differentiation
c0160165biological_processCD8-positive, alpha-beta T cell homeostasis
c2000045biological_processregulation of G1/S transition of mitotic cell cycle
C0000502cellular_componentproteasome complex
C0000932cellular_componentP-body
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006281biological_processDNA repair
C0006511biological_processubiquitin-dependent protein catabolic process
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0006979biological_processresponse to oxidative stress
C0007283biological_processspermatogenesis
C0008021cellular_componentsynaptic vesicle
C0009615biological_processresponse to virus
C0010498biological_processproteasomal protein catabolic process
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0030317biological_processflagellated sperm motility
C0032729biological_processpositive regulation of type II interferon production
C0032743biological_processpositive regulation of interleukin-2 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034341biological_processresponse to type II interferon
C0034515cellular_componentproteasome storage granule
C0034774cellular_componentsecretory granule lumen
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043374biological_processCD8-positive, alpha-beta T cell differentiation
C0045061biological_processthymic T cell selection
C0045063biological_processT-helper 1 cell differentiation
C0045590biological_processnegative regulation of regulatory T cell differentiation
C0051321biological_processmeiotic cell cycle
C0051603biological_processobsolete proteolysis involved in protein catabolic process
C0061136biological_processregulation of proteasomal protein catabolic process
C0070062cellular_componentextracellular exosome
C0071357biological_processcellular response to type I interferon
C0072539biological_processT-helper 17 cell differentiation
C0160165biological_processCD8-positive, alpha-beta T cell homeostasis
C1904813cellular_componentficolin-1-rich granule lumen
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
d0000502cellular_componentproteasome complex
d0002376biological_processimmune system process
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0005839cellular_componentproteasome core complex
d0006281biological_processDNA repair
d0006915biological_processapoptotic process
d0006974biological_processDNA damage response
d0006979biological_processresponse to oxidative stress
d0007283biological_processspermatogenesis
d0008021cellular_componentsynaptic vesicle
d0010498biological_processproteasomal protein catabolic process
d0010499biological_processproteasomal ubiquitin-independent protein catabolic process
d0016020cellular_componentmembrane
d0019774cellular_componentproteasome core complex, beta-subunit complex
d0030317biological_processflagellated sperm motility
d0032729biological_processpositive regulation of type II interferon production
d0032743biological_processpositive regulation of interleukin-2 production
d0032760biological_processpositive regulation of tumor necrosis factor production
d0034341biological_processresponse to type II interferon
d0034515cellular_componentproteasome storage granule
d0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
d0043374biological_processCD8-positive, alpha-beta T cell differentiation
d0045061biological_processthymic T cell selection
d0045063biological_processT-helper 1 cell differentiation
d0045590biological_processnegative regulation of regulatory T cell differentiation
d0051321biological_processmeiotic cell cycle
d0051603biological_processobsolete proteolysis involved in protein catabolic process
d0061136biological_processregulation of proteasomal protein catabolic process
d0070062cellular_componentextracellular exosome
d0071357biological_processcellular response to type I interferon
d0072539biological_processT-helper 17 cell differentiation
d0160165biological_processCD8-positive, alpha-beta T cell homeostasis
d2000045biological_processregulation of G1/S transition of mitotic cell cycle
D0000502cellular_componentproteasome complex
D0000932cellular_componentP-body
D0002376biological_processimmune system process
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005839cellular_componentproteasome core complex
D0006281biological_processDNA repair
D0006511biological_processubiquitin-dependent protein catabolic process
D0006915biological_processapoptotic process
D0006974biological_processDNA damage response
D0006979biological_processresponse to oxidative stress
D0007283biological_processspermatogenesis
D0008021cellular_componentsynaptic vesicle
D0010498biological_processproteasomal protein catabolic process
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0030317biological_processflagellated sperm motility
D0032729biological_processpositive regulation of type II interferon production
D0032743biological_processpositive regulation of interleukin-2 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034341biological_processresponse to type II interferon
D0034515cellular_componentproteasome storage granule
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043374biological_processCD8-positive, alpha-beta T cell differentiation
D0045061biological_processthymic T cell selection
D0045063biological_processT-helper 1 cell differentiation
D0045590biological_processnegative regulation of regulatory T cell differentiation
D0051321biological_processmeiotic cell cycle
D0051603biological_processobsolete proteolysis involved in protein catabolic process
D0061136biological_processregulation of proteasomal protein catabolic process
D0070062cellular_componentextracellular exosome
D0071357biological_processcellular response to type I interferon
D0072539biological_processT-helper 17 cell differentiation
D0160165biological_processCD8-positive, alpha-beta T cell homeostasis
D2000045biological_processregulation of G1/S transition of mitotic cell cycle
e0000502cellular_componentproteasome complex
e0004175molecular_functionendopeptidase activity
e0004298molecular_functionthreonine-type endopeptidase activity
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005737cellular_componentcytoplasm
e0005829cellular_componentcytosol
e0005839cellular_componentproteasome core complex
e0006281biological_processDNA repair
e0006508biological_processproteolysis
e0006915biological_processapoptotic process
e0006974biological_processDNA damage response
e0006979biological_processresponse to oxidative stress
e0007283biological_processspermatogenesis
e0008021cellular_componentsynaptic vesicle
e0008233molecular_functionpeptidase activity
e0010498biological_processproteasomal protein catabolic process
e0010499biological_processproteasomal ubiquitin-independent protein catabolic process
e0016787molecular_functionhydrolase activity
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g0019774cellular_componentproteasome core complex, beta-subunit complex
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h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
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h0043374biological_processCD8-positive, alpha-beta T cell differentiation
h0045061biological_processthymic T cell selection
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h0070062cellular_componentextracellular exosome
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h2000045biological_processregulation of G1/S transition of mitotic cell cycle
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H0000502cellular_componentproteasome complex
H0000932cellular_componentP-body
H0001649biological_processosteoblast differentiation
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i0006974biological_processDNA damage response
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k0019773cellular_componentproteasome core complex, alpha-subunit complex
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k0032760biological_processpositive regulation of tumor necrosis factor production
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k0043374biological_processCD8-positive, alpha-beta T cell differentiation
k0045061biological_processthymic T cell selection
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l0005737cellular_componentcytoplasm
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l0007283biological_processspermatogenesis
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l0045061biological_processthymic T cell selection
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l0072539biological_processT-helper 17 cell differentiation
l0160165biological_processCD8-positive, alpha-beta T cell homeostasis
l1904813cellular_componentficolin-1-rich granule lumen
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L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
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L0008021cellular_componentsynaptic vesicle
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L0070062cellular_componentextracellular exosome
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m0002376biological_processimmune system process
m0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
m0005515molecular_functionprotein binding
m0005634cellular_componentnucleus
m0005654cellular_componentnucleoplasm
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0005839cellular_componentproteasome core complex
m0006281biological_processDNA repair
m0006511biological_processubiquitin-dependent protein catabolic process
m0006915biological_processapoptotic process
m0006974biological_processDNA damage response
m0006979biological_processresponse to oxidative stress
m0007283biological_processspermatogenesis
m0008021cellular_componentsynaptic vesicle
m0010498biological_processproteasomal protein catabolic process
m0010499biological_processproteasomal ubiquitin-independent protein catabolic process
m0016604cellular_componentnuclear body
m0019773cellular_componentproteasome core complex, alpha-subunit complex
m0030317biological_processflagellated sperm motility
m0032729biological_processpositive regulation of type II interferon production
m0032743biological_processpositive regulation of interleukin-2 production
m0032760biological_processpositive regulation of tumor necrosis factor production
m0034341biological_processresponse to type II interferon
m0034515cellular_componentproteasome storage granule
m0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
m0043374biological_processCD8-positive, alpha-beta T cell differentiation
m0045061biological_processthymic T cell selection
m0045063biological_processT-helper 1 cell differentiation
m0045590biological_processnegative regulation of regulatory T cell differentiation
m0051321biological_processmeiotic cell cycle
m0051603biological_processobsolete proteolysis involved in protein catabolic process
m0061136biological_processregulation of proteasomal protein catabolic process
m0070062cellular_componentextracellular exosome
m0071357biological_processcellular response to type I interferon
m0072539biological_processT-helper 17 cell differentiation
m0160165biological_processCD8-positive, alpha-beta T cell homeostasis
m2000045biological_processregulation of G1/S transition of mitotic cell cycle
M0000166molecular_functionnucleotide binding
M0000502cellular_componentproteasome complex
M0000932cellular_componentP-body
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005576cellular_componentextracellular region
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0006979biological_processresponse to oxidative stress
M0008021cellular_componentsynaptic vesicle
M0008540cellular_componentproteasome regulatory particle, base subcomplex
M0010498biological_processproteasomal protein catabolic process
M0016020cellular_componentmembrane
M0016887molecular_functionATP hydrolysis activity
M0022624cellular_componentproteasome accessory complex
M0034774cellular_componentsecretory granule lumen
M0036402molecular_functionproteasome-activating activity
M0042802molecular_functionidentical protein binding
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0043921biological_processhost-mediated perturbation of viral transcription
M0045944biological_processpositive regulation of transcription by RNA polymerase II
M0061136biological_processregulation of proteasomal protein catabolic process
M0071357biological_processcellular response to type I interferon
M1901800biological_processpositive regulation of proteasomal protein catabolic process
M1904813cellular_componentficolin-1-rich granule lumen
n0000502cellular_componentproteasome complex
n0002376biological_processimmune system process
n0005515molecular_functionprotein binding
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005737cellular_componentcytoplasm
n0005829cellular_componentcytosol
n0005839cellular_componentproteasome core complex
n0006281biological_processDNA repair
n0006511biological_processubiquitin-dependent protein catabolic process
n0006915biological_processapoptotic process
n0006974biological_processDNA damage response
n0006979biological_processresponse to oxidative stress
n0007283biological_processspermatogenesis
n0008021cellular_componentsynaptic vesicle
n0010498biological_processproteasomal protein catabolic process
n0010499biological_processproteasomal ubiquitin-independent protein catabolic process
n0019773cellular_componentproteasome core complex, alpha-subunit complex
n0030317biological_processflagellated sperm motility
n0031625molecular_functionubiquitin protein ligase binding
n0032729biological_processpositive regulation of type II interferon production
n0032743biological_processpositive regulation of interleukin-2 production
n0032760biological_processpositive regulation of tumor necrosis factor production
n0034341biological_processresponse to type II interferon
n0034515cellular_componentproteasome storage granule
n0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
n0043374biological_processCD8-positive, alpha-beta T cell differentiation
n0045061biological_processthymic T cell selection
n0045063biological_processT-helper 1 cell differentiation
n0045590biological_processnegative regulation of regulatory T cell differentiation
n0051321biological_processmeiotic cell cycle
n0051603biological_processobsolete proteolysis involved in protein catabolic process
n0061136biological_processregulation of proteasomal protein catabolic process
n0070062cellular_componentextracellular exosome
n0071357biological_processcellular response to type I interferon
n0072539biological_processT-helper 17 cell differentiation
n0160165biological_processCD8-positive, alpha-beta T cell homeostasis
n2000045biological_processregulation of G1/S transition of mitotic cell cycle
N0000502cellular_componentproteasome complex
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005829cellular_componentcytosol
N0005838cellular_componentproteasome regulatory particle
N0006979biological_processresponse to oxidative stress
N0008021cellular_componentsynaptic vesicle
N0008540cellular_componentproteasome regulatory particle, base subcomplex
N0010498biological_processproteasomal protein catabolic process
N0016020cellular_componentmembrane
N0022624cellular_componentproteasome accessory complex
N0030234molecular_functionenzyme regulator activity
N0031625molecular_functionubiquitin protein ligase binding
N0034515cellular_componentproteasome storage granule
N0035578cellular_componentazurophil granule lumen
N0042176biological_processregulation of protein catabolic process
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0061136biological_processregulation of proteasomal protein catabolic process
N0071357biological_processcellular response to type I interferon
o0000502cellular_componentproteasome complex
o0004175molecular_functionendopeptidase activity
o0004298molecular_functionthreonine-type endopeptidase activity
o0005515molecular_functionprotein binding
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0005737cellular_componentcytoplasm
o0005829cellular_componentcytosol
o0005839cellular_componentproteasome core complex
o0006281biological_processDNA repair
o0006508biological_processproteolysis
o0006915biological_processapoptotic process
o0006974biological_processDNA damage response
o0006979biological_processresponse to oxidative stress
o0007283biological_processspermatogenesis
o0008021cellular_componentsynaptic vesicle
o0008233molecular_functionpeptidase activity
o0010498biological_processproteasomal protein catabolic process
o0010499biological_processproteasomal ubiquitin-independent protein catabolic process
o0016787molecular_functionhydrolase activity
o0019774cellular_componentproteasome core complex, beta-subunit complex
o0030317biological_processflagellated sperm motility
o0034515cellular_componentproteasome storage granule
o0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
o0045296molecular_functioncadherin binding
o0051321biological_processmeiotic cell cycle
o0051603biological_processobsolete proteolysis involved in protein catabolic process
o0061136biological_processregulation of proteasomal protein catabolic process
o0070062cellular_componentextracellular exosome
o0071357biological_processcellular response to type I interferon
o2000045biological_processregulation of G1/S transition of mitotic cell cycle
O0000502cellular_componentproteasome complex
O0005198molecular_functionstructural molecule activity
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005829cellular_componentcytosol
O0005838cellular_componentproteasome regulatory particle
O0006511biological_processubiquitin-dependent protein catabolic process
O0006979biological_processresponse to oxidative stress
O0008021cellular_componentsynaptic vesicle
O0008541cellular_componentproteasome regulatory particle, lid subcomplex
O0010498biological_processproteasomal protein catabolic process
O0016020cellular_componentmembrane
O0022624cellular_componentproteasome accessory complex
O0034774cellular_componentsecretory granule lumen
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0061136biological_processregulation of proteasomal protein catabolic process
O0071357biological_processcellular response to type I interferon
O1904813cellular_componentficolin-1-rich granule lumen
p0000502cellular_componentproteasome complex
p0004175molecular_functionendopeptidase activity
p0004298molecular_functionthreonine-type endopeptidase activity
p0005515molecular_functionprotein binding
p0005576cellular_componentextracellular region
p0005634cellular_componentnucleus
p0005654cellular_componentnucleoplasm
p0005737cellular_componentcytoplasm
p0005829cellular_componentcytosol
p0005839cellular_componentproteasome core complex
p0006281biological_processDNA repair
p0006508biological_processproteolysis
p0006915biological_processapoptotic process
p0006974biological_processDNA damage response
p0006979biological_processresponse to oxidative stress
p0007283biological_processspermatogenesis
p0008021cellular_componentsynaptic vesicle
p0008233molecular_functionpeptidase activity
p0010498biological_processproteasomal protein catabolic process
p0010499biological_processproteasomal ubiquitin-independent protein catabolic process
p0016604cellular_componentnuclear body
p0016787molecular_functionhydrolase activity
p0019774cellular_componentproteasome core complex, beta-subunit complex
p0030317biological_processflagellated sperm motility
p0034515cellular_componentproteasome storage granule
p0034774cellular_componentsecretory granule lumen
p0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
p0051321biological_processmeiotic cell cycle
p0051603biological_processobsolete proteolysis involved in protein catabolic process
p0061136biological_processregulation of proteasomal protein catabolic process
p0071357biological_processcellular response to type I interferon
p1904813cellular_componentficolin-1-rich granule lumen
p2000045biological_processregulation of G1/S transition of mitotic cell cycle
P0000502cellular_componentproteasome complex
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005654cellular_componentnucleoplasm
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005838cellular_componentproteasome regulatory particle
P0006979biological_processresponse to oxidative stress
P0008021cellular_componentsynaptic vesicle
P0008541cellular_componentproteasome regulatory particle, lid subcomplex
P0010498biological_processproteasomal protein catabolic process
P0016020cellular_componentmembrane
P0022624cellular_componentproteasome accessory complex
P0034774cellular_componentsecretory granule lumen
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0061136biological_processregulation of proteasomal protein catabolic process
P0070062cellular_componentextracellular exosome
P0071357biological_processcellular response to type I interferon
P1904813cellular_componentficolin-1-rich granule lumen
q0000502cellular_componentproteasome complex
q0002376biological_processimmune system process
q0005515molecular_functionprotein binding
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005737cellular_componentcytoplasm
q0005829cellular_componentcytosol
q0005839cellular_componentproteasome core complex
q0006281biological_processDNA repair
q0006915biological_processapoptotic process
q0006974biological_processDNA damage response
q0006979biological_processresponse to oxidative stress
q0007283biological_processspermatogenesis
q0008021cellular_componentsynaptic vesicle
q0010498biological_processproteasomal protein catabolic process
q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
q0019774cellular_componentproteasome core complex, beta-subunit complex
q0030317biological_processflagellated sperm motility
q0032729biological_processpositive regulation of type II interferon production
q0032743biological_processpositive regulation of interleukin-2 production
q0032760biological_processpositive regulation of tumor necrosis factor production
q0034341biological_processresponse to type II interferon
q0034515cellular_componentproteasome storage granule
q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
q0043374biological_processCD8-positive, alpha-beta T cell differentiation
q0045061biological_processthymic T cell selection
q0045063biological_processT-helper 1 cell differentiation
q0045590biological_processnegative regulation of regulatory T cell differentiation
q0051321biological_processmeiotic cell cycle
q0051603biological_processobsolete proteolysis involved in protein catabolic process
q0061136biological_processregulation of proteasomal protein catabolic process
q0070062cellular_componentextracellular exosome
q0071357biological_processcellular response to type I interferon
q0072539biological_processT-helper 17 cell differentiation
q0160165biological_processCD8-positive, alpha-beta T cell homeostasis
q2000045biological_processregulation of G1/S transition of mitotic cell cycle
Q0000502cellular_componentproteasome complex
Q0005198molecular_functionstructural molecule activity
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005829cellular_componentcytosol
Q0005838cellular_componentproteasome regulatory particle
Q0006511biological_processubiquitin-dependent protein catabolic process
Q0006979biological_processresponse to oxidative stress
Q0008021cellular_componentsynaptic vesicle
Q0008541cellular_componentproteasome regulatory particle, lid subcomplex
Q0010498biological_processproteasomal protein catabolic process
Q0016020cellular_componentmembrane
Q0022624cellular_componentproteasome accessory complex
Q0032991cellular_componentprotein-containing complex
Q0034774cellular_componentsecretory granule lumen
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0043248biological_processproteasome assembly
Q0048863biological_processstem cell differentiation
Q0061136biological_processregulation of proteasomal protein catabolic process
Q0071357biological_processcellular response to type I interferon
Q1904813cellular_componentficolin-1-rich granule lumen
r0000502cellular_componentproteasome complex
r0002376biological_processimmune system process
r0005515molecular_functionprotein binding
r0005634cellular_componentnucleus
r0005654cellular_componentnucleoplasm
r0005737cellular_componentcytoplasm
r0005829cellular_componentcytosol
r0005839cellular_componentproteasome core complex
r0006281biological_processDNA repair
r0006915biological_processapoptotic process
r0006974biological_processDNA damage response
r0006979biological_processresponse to oxidative stress
r0007283biological_processspermatogenesis
r0008021cellular_componentsynaptic vesicle
r0010498biological_processproteasomal protein catabolic process
r0010499biological_processproteasomal ubiquitin-independent protein catabolic process
r0016020cellular_componentmembrane
r0019774cellular_componentproteasome core complex, beta-subunit complex
r0030317biological_processflagellated sperm motility
r0032729biological_processpositive regulation of type II interferon production
r0032743biological_processpositive regulation of interleukin-2 production
r0032760biological_processpositive regulation of tumor necrosis factor production
r0034341biological_processresponse to type II interferon
r0034515cellular_componentproteasome storage granule
r0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
r0043374biological_processCD8-positive, alpha-beta T cell differentiation
r0045061biological_processthymic T cell selection
r0045063biological_processT-helper 1 cell differentiation
r0045590biological_processnegative regulation of regulatory T cell differentiation
r0051321biological_processmeiotic cell cycle
r0051603biological_processobsolete proteolysis involved in protein catabolic process
r0061136biological_processregulation of proteasomal protein catabolic process
r0070062cellular_componentextracellular exosome
r0071357biological_processcellular response to type I interferon
r0072539biological_processT-helper 17 cell differentiation
r0160165biological_processCD8-positive, alpha-beta T cell homeostasis
r2000045biological_processregulation of G1/S transition of mitotic cell cycle
R0000502cellular_componentproteasome complex
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005654cellular_componentnucleoplasm
R0005829cellular_componentcytosol
R0005838cellular_componentproteasome regulatory particle
R0006979biological_processresponse to oxidative stress
R0008021cellular_componentsynaptic vesicle
R0010498biological_processproteasomal protein catabolic process
R0022624cellular_componentproteasome accessory complex
R0032991cellular_componentprotein-containing complex
R0034774cellular_componentsecretory granule lumen
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0061136biological_processregulation of proteasomal protein catabolic process
R0071357biological_processcellular response to type I interferon
R1904813cellular_componentficolin-1-rich granule lumen
s0000502cellular_componentproteasome complex
s0004175molecular_functionendopeptidase activity
s0004298molecular_functionthreonine-type endopeptidase activity
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005654cellular_componentnucleoplasm
s0005737cellular_componentcytoplasm
s0005829cellular_componentcytosol
s0005839cellular_componentproteasome core complex
s0006281biological_processDNA repair
s0006508biological_processproteolysis
s0006915biological_processapoptotic process
s0006974biological_processDNA damage response
s0006979biological_processresponse to oxidative stress
s0007283biological_processspermatogenesis
s0008021cellular_componentsynaptic vesicle
s0008233molecular_functionpeptidase activity
s0010498biological_processproteasomal protein catabolic process
s0010499biological_processproteasomal ubiquitin-independent protein catabolic process
s0016787molecular_functionhydrolase activity
s0019774cellular_componentproteasome core complex, beta-subunit complex
s0030317biological_processflagellated sperm motility
s0034515cellular_componentproteasome storage granule
s0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
s0043248biological_processproteasome assembly
s0051321biological_processmeiotic cell cycle
s0051603biological_processobsolete proteolysis involved in protein catabolic process
s0061136biological_processregulation of proteasomal protein catabolic process
s0070062cellular_componentextracellular exosome
s0071357biological_processcellular response to type I interferon
s2000045biological_processregulation of G1/S transition of mitotic cell cycle
S0000502cellular_componentproteasome complex
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005829cellular_componentcytosol
S0005838cellular_componentproteasome regulatory particle
S0006511biological_processubiquitin-dependent protein catabolic process
S0006979biological_processresponse to oxidative stress
S0008021cellular_componentsynaptic vesicle
S0008541cellular_componentproteasome regulatory particle, lid subcomplex
S0010498biological_processproteasomal protein catabolic process
S0016020cellular_componentmembrane
S0022624cellular_componentproteasome accessory complex
S0030234molecular_functionenzyme regulator activity
S0034774cellular_componentsecretory granule lumen
S0042176biological_processregulation of protein catabolic process
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0061136biological_processregulation of proteasomal protein catabolic process
S0070062cellular_componentextracellular exosome
S0071357biological_processcellular response to type I interferon
S1904813cellular_componentficolin-1-rich granule lumen
t0000502cellular_componentproteasome complex
t0002376biological_processimmune system process
t0005515molecular_functionprotein binding
t0005576cellular_componentextracellular region
t0005634cellular_componentnucleus
t0005654cellular_componentnucleoplasm
t0005737cellular_componentcytoplasm
t0005829cellular_componentcytosol
t0005839cellular_componentproteasome core complex
t0006281biological_processDNA repair
t0006915biological_processapoptotic process
t0006974biological_processDNA damage response
t0006979biological_processresponse to oxidative stress
t0007283biological_processspermatogenesis
t0008021cellular_componentsynaptic vesicle
t0010498biological_processproteasomal protein catabolic process
t0010499biological_processproteasomal ubiquitin-independent protein catabolic process
t0019774cellular_componentproteasome core complex, beta-subunit complex
t0030317biological_processflagellated sperm motility
t0032729biological_processpositive regulation of type II interferon production
t0032743biological_processpositive regulation of interleukin-2 production
t0032760biological_processpositive regulation of tumor necrosis factor production
t0034341biological_processresponse to type II interferon
t0034515cellular_componentproteasome storage granule
t0034774cellular_componentsecretory granule lumen
t0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
t0043374biological_processCD8-positive, alpha-beta T cell differentiation
t0045061biological_processthymic T cell selection
t0045063biological_processT-helper 1 cell differentiation
t0045590biological_processnegative regulation of regulatory T cell differentiation
t0051321biological_processmeiotic cell cycle
t0051603biological_processobsolete proteolysis involved in protein catabolic process
t0061136biological_processregulation of proteasomal protein catabolic process
t0070062cellular_componentextracellular exosome
t0071357biological_processcellular response to type I interferon
t0072539biological_processT-helper 17 cell differentiation
t0160165biological_processCD8-positive, alpha-beta T cell homeostasis
t1904813cellular_componentficolin-1-rich granule lumen
t2000045biological_processregulation of G1/S transition of mitotic cell cycle
T0000502cellular_componentproteasome complex
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005829cellular_componentcytosol
T0005838cellular_componentproteasome regulatory particle
T0006508biological_processproteolysis
T0006979biological_processresponse to oxidative stress
T0008021cellular_componentsynaptic vesicle
T0008541cellular_componentproteasome regulatory particle, lid subcomplex
T0010498biological_processproteasomal protein catabolic process
T0022624cellular_componentproteasome accessory complex
T0032991cellular_componentprotein-containing complex
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0061136biological_processregulation of proteasomal protein catabolic process
T0071357biological_processcellular response to type I interferon
u0000502cellular_componentproteasome complex
u0001530molecular_functionlipopolysaccharide binding
u0002376biological_processimmune system process
u0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
u0005515molecular_functionprotein binding
u0005634cellular_componentnucleus
u0005654cellular_componentnucleoplasm
u0005737cellular_componentcytoplasm
u0005829cellular_componentcytosol
u0005839cellular_componentproteasome core complex
u0006281biological_processDNA repair
u0006915biological_processapoptotic process
u0006974biological_processDNA damage response
u0006979biological_processresponse to oxidative stress
u0007283biological_processspermatogenesis
u0008021cellular_componentsynaptic vesicle
u0010498biological_processproteasomal protein catabolic process
u0010499biological_processproteasomal ubiquitin-independent protein catabolic process
u0019774cellular_componentproteasome core complex, beta-subunit complex
u0030317biological_processflagellated sperm motility
u0032729biological_processpositive regulation of type II interferon production
u0032743biological_processpositive regulation of interleukin-2 production
u0032760biological_processpositive regulation of tumor necrosis factor production
u0034341biological_processresponse to type II interferon
u0034515cellular_componentproteasome storage granule
u0036064cellular_componentciliary basal body
u0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
u0043374biological_processCD8-positive, alpha-beta T cell differentiation
u0045061biological_processthymic T cell selection
u0045063biological_processT-helper 1 cell differentiation
u0045590biological_processnegative regulation of regulatory T cell differentiation
u0051321biological_processmeiotic cell cycle
u0051603biological_processobsolete proteolysis involved in protein catabolic process
u0061136biological_processregulation of proteasomal protein catabolic process
u0070062cellular_componentextracellular exosome
u0071357biological_processcellular response to type I interferon
u0072539biological_processT-helper 17 cell differentiation
u0160165biological_processCD8-positive, alpha-beta T cell homeostasis
u2000045biological_processregulation of G1/S transition of mitotic cell cycle
U0000502cellular_componentproteasome complex
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005829cellular_componentcytosol
U0005838cellular_componentproteasome regulatory particle
U0006979biological_processresponse to oxidative stress
U0008021cellular_componentsynaptic vesicle
U0008233molecular_functionpeptidase activity
U0008237molecular_functionmetallopeptidase activity
U0010498biological_processproteasomal protein catabolic process
U0016020cellular_componentmembrane
U0034774cellular_componentsecretory granule lumen
U0042803molecular_functionprotein homodimerization activity
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0061136biological_processregulation of proteasomal protein catabolic process
U0070062cellular_componentextracellular exosome
U0071357biological_processcellular response to type I interferon
U0140492molecular_functionmetal-dependent deubiquitinase activity
U1904813cellular_componentficolin-1-rich granule lumen
v0000166molecular_functionnucleotide binding
v0000502cellular_componentproteasome complex
v0000932cellular_componentP-body
v0001649biological_processosteoblast differentiation
v0005515molecular_functionprotein binding
v0005524molecular_functionATP binding
v0005576cellular_componentextracellular region
v0005634cellular_componentnucleus
v0005654cellular_componentnucleoplasm
v0005737cellular_componentcytoplasm
v0005829cellular_componentcytosol
v0006511biological_processubiquitin-dependent protein catabolic process
v0006979biological_processresponse to oxidative stress
v0008021cellular_componentsynaptic vesicle
v0008540cellular_componentproteasome regulatory particle, base subcomplex
v0010498biological_processproteasomal protein catabolic process
v0016020cellular_componentmembrane
v0016887molecular_functionATP hydrolysis activity
v0022624cellular_componentproteasome accessory complex
v0034774cellular_componentsecretory granule lumen
v0036402molecular_functionproteasome-activating activity
v0036464cellular_componentcytoplasmic ribonucleoprotein granule
v0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
v0061136biological_processregulation of proteasomal protein catabolic process
v0071357biological_processcellular response to type I interferon
v1901800biological_processpositive regulation of proteasomal protein catabolic process
v1904813cellular_componentficolin-1-rich granule lumen
V0000502cellular_componentproteasome complex
V0000724biological_processdouble-strand break repair via homologous recombination
V0004843molecular_functioncysteine-type deubiquitinase activity
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005829cellular_componentcytosol
V0006281biological_processDNA repair
V0006303biological_processdouble-strand break repair via nonhomologous end joining
V0006508biological_processproteolysis
V0006511biological_processubiquitin-dependent protein catabolic process
V0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
V0006914biological_processautophagy
V0006974biological_processDNA damage response
V0006979biological_processresponse to oxidative stress
V0008021cellular_componentsynaptic vesicle
V0008233molecular_functionpeptidase activity
V0008234molecular_functioncysteine-type peptidase activity
V0008237molecular_functionmetallopeptidase activity
V0008541cellular_componentproteasome regulatory particle, lid subcomplex
V0010498biological_processproteasomal protein catabolic process
V0016192biological_processvesicle-mediated transport
V0016241biological_processregulation of macroautophagy
V0016579biological_processprotein deubiquitination
V0016787molecular_functionhydrolase activity
V0022624cellular_componentproteasome accessory complex
V0031597cellular_componentcytosolic proteasome complex
V0034774cellular_componentsecretory granule lumen
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0045471biological_processresponse to ethanol
V0046872molecular_functionmetal ion binding
V0061133molecular_functionendopeptidase activator activity
V0061136biological_processregulation of proteasomal protein catabolic process
V0061578molecular_functionK63-linked deubiquitinase activity
V0070536biological_processprotein K63-linked deubiquitination
V0070628molecular_functionproteasome binding
V0071357biological_processcellular response to type I interferon
V0140492molecular_functionmetal-dependent deubiquitinase activity
V1904813cellular_componentficolin-1-rich granule lumen
w0000166molecular_functionnucleotide binding
w0000502cellular_componentproteasome complex
w0003723molecular_functionRNA binding
w0005515molecular_functionprotein binding
w0005524molecular_functionATP binding
w0005634cellular_componentnucleus
w0005654cellular_componentnucleoplasm
w0005737cellular_componentcytoplasm
w0005829cellular_componentcytosol
w0005838cellular_componentproteasome regulatory particle
w0006979biological_processresponse to oxidative stress
w0008021cellular_componentsynaptic vesicle
w0008540cellular_componentproteasome regulatory particle, base subcomplex
w0010498biological_processproteasomal protein catabolic process
w0016020cellular_componentmembrane
w0016887molecular_functionATP hydrolysis activity
w0022624cellular_componentproteasome accessory complex
w0036402molecular_functionproteasome-activating activity
w0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
w0061136biological_processregulation of proteasomal protein catabolic process
w0071357biological_processcellular response to type I interferon
W0000502cellular_componentproteasome complex
W0003723molecular_functionRNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005829cellular_componentcytosol
W0006979biological_processresponse to oxidative stress
W0008021cellular_componentsynaptic vesicle
W0008540cellular_componentproteasome regulatory particle, base subcomplex
W0010498biological_processproteasomal protein catabolic process
W0022624cellular_componentproteasome accessory complex
W0031593molecular_functionpolyubiquitin modification-dependent protein binding
W0042802molecular_functionidentical protein binding
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0060090molecular_functionmolecular adaptor activity
W0061136biological_processregulation of proteasomal protein catabolic process
W0071357biological_processcellular response to type I interferon
x0000166molecular_functionnucleotide binding
x0000502cellular_componentproteasome complex
x0005102molecular_functionsignaling receptor binding
x0005515molecular_functionprotein binding
x0005524molecular_functionATP binding
x0005634cellular_componentnucleus
x0005654cellular_componentnucleoplasm
x0005737cellular_componentcytoplasm
x0005829cellular_componentcytosol
x0005838cellular_componentproteasome regulatory particle
x0005886cellular_componentplasma membrane
x0006357biological_processregulation of transcription by RNA polymerase II
x0006979biological_processresponse to oxidative stress
x0008021cellular_componentsynaptic vesicle
x0008134molecular_functiontranscription factor binding
x0008540cellular_componentproteasome regulatory particle, base subcomplex
x0010498biological_processproteasomal protein catabolic process
x0016020cellular_componentmembrane
x0016234cellular_componentinclusion body
x0016887molecular_functionATP hydrolysis activity
x0017025molecular_functionTBP-class protein binding
x0022624cellular_componentproteasome accessory complex
x0031410cellular_componentcytoplasmic vesicle
x0031531molecular_functionthyrotropin-releasing hormone receptor binding
x0031595cellular_componentnuclear proteasome complex
x0031597cellular_componentcytosolic proteasome complex
x0036402molecular_functionproteasome-activating activity
x0043069biological_processnegative regulation of programmed cell death
x0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
x0045893biological_processpositive regulation of DNA-templated transcription
x0061136biological_processregulation of proteasomal protein catabolic process
x0070062cellular_componentextracellular exosome
x0071357biological_processcellular response to type I interferon
x0072562cellular_componentblood microparticle
x0090261biological_processpositive regulation of inclusion body assembly
x0140296molecular_functiongeneral transcription initiation factor binding
x0140297molecular_functionDNA-binding transcription factor binding
x1901800biological_processpositive regulation of proteasomal protein catabolic process
X0000502cellular_componentproteasome complex
X0002376biological_processimmune system process
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0005839cellular_componentproteasome core complex
X0006281biological_processDNA repair
X0006511biological_processubiquitin-dependent protein catabolic process
X0006915biological_processapoptotic process
X0006974biological_processDNA damage response
X0006979biological_processresponse to oxidative stress
X0007283biological_processspermatogenesis
X0008021cellular_componentsynaptic vesicle
X0010498biological_processproteasomal protein catabolic process
X0010499biological_processproteasomal ubiquitin-independent protein catabolic process
X0019773cellular_componentproteasome core complex, alpha-subunit complex
X0030317biological_processflagellated sperm motility
X0031625molecular_functionubiquitin protein ligase binding
X0032729biological_processpositive regulation of type II interferon production
X0032743biological_processpositive regulation of interleukin-2 production
X0032760biological_processpositive regulation of tumor necrosis factor production
X0034341biological_processresponse to type II interferon
X0034515cellular_componentproteasome storage granule
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0043374biological_processCD8-positive, alpha-beta T cell differentiation
X0045061biological_processthymic T cell selection
X0045063biological_processT-helper 1 cell differentiation
X0045590biological_processnegative regulation of regulatory T cell differentiation
X0051321biological_processmeiotic cell cycle
X0051603biological_processobsolete proteolysis involved in protein catabolic process
X0061136biological_processregulation of proteasomal protein catabolic process
X0070062cellular_componentextracellular exosome
X0071357biological_processcellular response to type I interferon
X0072539biological_processT-helper 17 cell differentiation
X0160165biological_processCD8-positive, alpha-beta T cell homeostasis
X2000045biological_processregulation of G1/S transition of mitotic cell cycle
y0000166molecular_functionnucleotide binding
y0000502cellular_componentproteasome complex
y0005515molecular_functionprotein binding
y0005524molecular_functionATP binding
y0005634cellular_componentnucleus
y0005654cellular_componentnucleoplasm
y0005737cellular_componentcytoplasm
y0005829cellular_componentcytosol
y0006508biological_processproteolysis
y0006979biological_processresponse to oxidative stress
y0008021cellular_componentsynaptic vesicle
y0008540cellular_componentproteasome regulatory particle, base subcomplex
y0010498biological_processproteasomal protein catabolic process
y0016020cellular_componentmembrane
y0016887molecular_functionATP hydrolysis activity
y0022624cellular_componentproteasome accessory complex
y0036402molecular_functionproteasome-activating activity
y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
y0061136biological_processregulation of proteasomal protein catabolic process
y0071357biological_processcellular response to type I interferon
Y0000502cellular_componentproteasome complex
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0005829cellular_componentcytosol
Y0006406biological_processmRNA export from nucleus
Y0006979biological_processresponse to oxidative stress
Y0008021cellular_componentsynaptic vesicle
Y0008541cellular_componentproteasome regulatory particle, lid subcomplex
Y0010498biological_processproteasomal protein catabolic process
Y0032039cellular_componentintegrator complex
Y0032991cellular_componentprotein-containing complex
Y0043130molecular_functionubiquitin binding
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0043248biological_processproteasome assembly
Y0045944biological_processpositive regulation of transcription by RNA polymerase II
Y0061136biological_processregulation of proteasomal protein catabolic process
Y0071357biological_processcellular response to type I interferon
z0000166molecular_functionnucleotide binding
z0000502cellular_componentproteasome complex
z0005515molecular_functionprotein binding
z0005524molecular_functionATP binding
z0005634cellular_componentnucleus
z0005654cellular_componentnucleoplasm
z0005737cellular_componentcytoplasm
z0005829cellular_componentcytosol
z0006979biological_processresponse to oxidative stress
z0008021cellular_componentsynaptic vesicle
z0008540cellular_componentproteasome regulatory particle, base subcomplex
z0010498biological_processproteasomal protein catabolic process
z0016020cellular_componentmembrane
z0016234cellular_componentinclusion body
z0016887molecular_functionATP hydrolysis activity
z0022624cellular_componentproteasome accessory complex
z0030674molecular_functionprotein-macromolecule adaptor activity
z0031597cellular_componentcytosolic proteasome complex
z0036402molecular_functionproteasome-activating activity
z0036503biological_processERAD pathway
z0042802molecular_functionidentical protein binding
z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
z0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
z0061136biological_processregulation of proteasomal protein catabolic process
z0070062cellular_componentextracellular exosome
z0071357biological_processcellular response to type I interferon
z0090261biological_processpositive regulation of inclusion body assembly
z1901800biological_processpositive regulation of proteasomal protein catabolic process
Z0000502cellular_componentproteasome complex
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005829cellular_componentcytosol
Z0005838cellular_componentproteasome regulatory particle
Z0006979biological_processresponse to oxidative stress
Z0008021cellular_componentsynaptic vesicle
Z0008540cellular_componentproteasome regulatory particle, base subcomplex
Z0010498biological_processproteasomal protein catabolic process
Z0016020cellular_componentmembrane
Z0022624cellular_componentproteasome accessory complex
Z0030234molecular_functionenzyme regulator activity
Z0034515cellular_componentproteasome storage granule
Z0034774cellular_componentsecretory granule lumen
Z0042176biological_processregulation of protein catabolic process
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0061136biological_processregulation of proteasomal protein catabolic process
Z0070062cellular_componentextracellular exosome
Z0071357biological_processcellular response to type I interferon
Z1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue ADP I 501
ChainResidue
IASP186
ILYS237
IASN332
IILE364
IHIS368
IGLY392
IALA393
JARG307
JARG310
IILE187
IGLY188
IPRO228
IGLY229
IGLY231
ILYS232
ITHR233
ILEU234

site_idAC2
Number of Residues14
Detailsbinding site for residue ADP H 501
ChainResidue
HASP176
HGLY178
HPRO218
HGLY219
HTHR220
HGLY221
HLYS222
HTHR223
HLEU224
HGLY382
HALA383
IASP317
IARG343
IARG346

site_idAC3
Number of Residues14
Detailsbinding site for residue ADP L 401
ChainResidue
LGLY136
LGLY177
LGLY179
LLYS180
LTHR181
LLEU182
LASN280
LILE312
LHIS316
LGLY340
LALA341
LARG344
MARG344
MARG347

site_idAC4
Number of Residues14
Detailsbinding site for residue ADP M 501
ChainResidue
HARG333
MILE188
MGLY189
MPRO229
MGLY230
MTHR231
MGLY232
MLYS233
MTHR234
MLEU235
MASN333
MILE365
MHIS369
MLYS397

site_idAC5
Number of Residues13
Detailsbinding site for residue ADP J 501
ChainResidue
JILE151
JGLY152
JLEU154
JPRO192
JGLY193
JTHR194
JGLY195
JLYS196
JTHR197
JILE328
JHIS332
JGLY356
JLYS360

site_idAC6
Number of Residues14
Detailsbinding site for residue ADP K 501
ChainResidue
KASP166
KILE167
KGLY168
KGLY209
KCYS210
KGLY211
KLYS212
KTHR213
KMET214
KILE344
KGLY372
KALA373
LARG291
LARG294

site_idAC7
Number of Residues14
Detailsbinding site for residue ADP v 501
ChainResidue
wARG346
vASP176
vGLY178
vPRO218
vGLY219
vTHR220
vGLY221
vLYS222
vTHR223
vLEU224
vGLY382
vALA383
wASP317
wARG343

site_idAC8
Number of Residues17
Detailsbinding site for residue ADP w 501
ChainResidue
wASP186
wILE187
wGLY188
wPRO228
wGLY229
wGLY231
wLYS232
wTHR233
wLEU234
wLYS237
wASN332
wILE364
wHIS368
wGLY392
wALA393
xARG307
xARG310

site_idAC9
Number of Residues13
Detailsbinding site for residue ADP x 501
ChainResidue
xILE151
xGLY152
xLEU154
xPRO192
xGLY193
xTHR194
xGLY195
xLYS196
xTHR197
xILE328
xHIS332
xGLY356
xLYS360

site_idAD1
Number of Residues14
Detailsbinding site for residue ADP y 501
ChainResidue
yASP166
yILE167
yGLY168
yGLY209
yCYS210
yGLY211
yLYS212
yTHR213
yMET214
yILE344
yGLY372
yALA373
zARG291
zARG294

site_idAD2
Number of Residues14
Detailsbinding site for residue ADP z 401
ChainResidue
0ARG344
0ARG347
zGLY136
zGLY177
zGLY179
zLYS180
zTHR181
zLEU182
zASN280
zILE312
zHIS316
zGLY340
zALA341
zARG344

site_idAD3
Number of Residues14
Detailsbinding site for residue ADP 0 501
ChainResidue
0ILE188
0GLY189
0PRO229
0GLY230
0THR231
0GLY232
0LYS233
0THR234
0LEU235
0ASN333
0ILE365
0HIS369
0LYS397
vARG333

site_idAD4
Number of Residues10
Detailsbinding site for Di-peptide ILE 8 91 and CYS 8 116
ChainResidue
8LEU39
8LEU40
8TYR79
8ARG90
8VAL92
8MET112
8LYS113
8ARG114
8TYR115
8PRO117

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV
ChainResidueDetails
7ALA72-VAL87

site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA
ChainResidueDetails
iTYR5-ALA27
jTYR5-ALA27
lTYR8-ALA30
nTYR7-ALA29
mTYR6-ALA28
kTYR3-ALA25
hPHE9-ALA31

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IkVLmATNrpdtLDpALm.R
ChainResidueDetails
HILE315-ARG333
KVAL305-ARG323
MVAL326-ARG344
JILE289-ARG307
LVAL273-ARG291
IVAL325-ARG343

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIlAndGVLLAAErrnihklldevffse.KiyklnedmacsvaGitSD
ChainResidueDetails
jLEU35-ASP82
cMET12-ASP59
oMET4-ASP51
dILE5-ASP52
eLEU4-ASP51
gLEU12-ASP59
fLEU13-ASP60
bALA4-ASP51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues50
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues38
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues132
DetailsRepeat: {"description":"PC 1"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues138
DetailsRepeat: {"description":"PC 2"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues136
DetailsRepeat: {"description":"PC 3"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues136
DetailsRepeat: {"description":"PC 4"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues124
DetailsRepeat: {"description":"PC 5"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues132
DetailsRepeat: {"description":"PC 6"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues94
DetailsRepeat: {"description":"PC 7"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues68
DetailsRepeat: {"description":"PC 8"}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues80
DetailsRepeat: {"description":"PC 9"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3TXS7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues1702
DetailsDomain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Potts A.","Brablan J.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues48
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues26
DetailsMotif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues366
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues10
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues6
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

249697

PDB entries from 2026-02-25

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