5GJR

An atomic structure of the human 26S proteasome

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000166	molecular_function	nucleotide binding
0	0000502	cellular_component	proteasome complex
0	0000932	cellular_component	P-body
0	0001824	biological_process	blastocyst development
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005576	cellular_component	extracellular region
0	0005634	cellular_component	nucleus
0	0005654	cellular_component	nucleoplasm
0	0005737	cellular_component	cytoplasm
0	0005829	cellular_component	cytosol
0	0008540	cellular_component	proteasome regulatory particle, base subcomplex
0	0016020	cellular_component	membrane
0	0016887	molecular_function	ATP hydrolysis activity
0	0022624	cellular_component	proteasome accessory complex
0	0034774	cellular_component	secretory granule lumen
0	0036402	molecular_function	proteasome-activating activity
0	0042802	molecular_function	identical protein binding
0	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
0	0043921	biological_process	host-mediated perturbation of viral transcription
0	0045944	biological_process	positive regulation of transcription by RNA polymerase II
0	1901800	biological_process	positive regulation of proteasomal protein catabolic process
0	1904813	cellular_component	ficolin-1-rich granule lumen
1	0000502	cellular_component	proteasome complex
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005829	cellular_component	cytosol
1	0005838	cellular_component	proteasome regulatory particle
1	0008540	cellular_component	proteasome regulatory particle, base subcomplex
1	0016020	cellular_component	membrane
1	0022624	cellular_component	proteasome accessory complex
1	0030234	molecular_function	enzyme regulator activity
1	0031625	molecular_function	ubiquitin protein ligase binding
1	0034515	cellular_component	proteasome storage granule
1	0035578	cellular_component	azurophil granule lumen
1	0042176	biological_process	regulation of protein catabolic process
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0000502	cellular_component	proteasome complex
2	0005198	molecular_function	structural molecule activity
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005829	cellular_component	cytosol
2	0005838	cellular_component	proteasome regulatory particle
2	0006511	biological_process	ubiquitin-dependent protein catabolic process
2	0007127	biological_process	meiosis I
2	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
2	0016020	cellular_component	membrane
2	0022624	cellular_component	proteasome accessory complex
2	0034774	cellular_component	secretory granule lumen
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	1904813	cellular_component	ficolin-1-rich granule lumen
3	0000502	cellular_component	proteasome complex
3	0005515	molecular_function	protein binding
3	0005576	cellular_component	extracellular region
3	0005654	cellular_component	nucleoplasm
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005838	cellular_component	proteasome regulatory particle
3	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
3	0016020	cellular_component	membrane
3	0022624	cellular_component	proteasome accessory complex
3	0034774	cellular_component	secretory granule lumen
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0070062	cellular_component	extracellular exosome
3	1904813	cellular_component	ficolin-1-rich granule lumen
4	0000502	cellular_component	proteasome complex
4	0005198	molecular_function	structural molecule activity
4	0005515	molecular_function	protein binding
4	0005576	cellular_component	extracellular region
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005737	cellular_component	cytoplasm
4	0005829	cellular_component	cytosol
4	0005838	cellular_component	proteasome regulatory particle
4	0006511	biological_process	ubiquitin-dependent protein catabolic process
4	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
4	0016020	cellular_component	membrane
4	0022624	cellular_component	proteasome accessory complex
4	0032991	cellular_component	protein-containing complex
4	0034774	cellular_component	secretory granule lumen
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0043248	biological_process	proteasome assembly
4	0048863	biological_process	stem cell differentiation
4	1904813	cellular_component	ficolin-1-rich granule lumen
5	0000502	cellular_component	proteasome complex
5	0005515	molecular_function	protein binding
5	0005576	cellular_component	extracellular region
5	0005654	cellular_component	nucleoplasm
5	0005829	cellular_component	cytosol
5	0005838	cellular_component	proteasome regulatory particle
5	0022624	cellular_component	proteasome accessory complex
5	0032991	cellular_component	protein-containing complex
5	0034774	cellular_component	secretory granule lumen
5	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
5	1904813	cellular_component	ficolin-1-rich granule lumen
6	0000502	cellular_component	proteasome complex
6	0005515	molecular_function	protein binding
6	0005576	cellular_component	extracellular region
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005829	cellular_component	cytosol
6	0005838	cellular_component	proteasome regulatory particle
6	0006511	biological_process	ubiquitin-dependent protein catabolic process
6	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
6	0016020	cellular_component	membrane
6	0022624	cellular_component	proteasome accessory complex
6	0030234	molecular_function	enzyme regulator activity
6	0034774	cellular_component	secretory granule lumen
6	0042176	biological_process	regulation of protein catabolic process
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0070062	cellular_component	extracellular exosome
6	1904813	cellular_component	ficolin-1-rich granule lumen
7	0000502	cellular_component	proteasome complex
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005829	cellular_component	cytosol
7	0005838	cellular_component	proteasome regulatory particle
7	0006508	biological_process	proteolysis
7	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
7	0022624	cellular_component	proteasome accessory complex
7	0032991	cellular_component	protein-containing complex
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
8	0000502	cellular_component	proteasome complex
8	0005515	molecular_function	protein binding
8	0005576	cellular_component	extracellular region
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005829	cellular_component	cytosol
8	0005838	cellular_component	proteasome regulatory particle
8	0008233	molecular_function	peptidase activity
8	0008237	molecular_function	metallopeptidase activity
8	0016020	cellular_component	membrane
8	0034774	cellular_component	secretory granule lumen
8	0042803	molecular_function	protein homodimerization activity
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
8	0070062	cellular_component	extracellular exosome
8	0140492	molecular_function	metal-dependent deubiquitinase activity
8	1904813	cellular_component	ficolin-1-rich granule lumen
9	0000502	cellular_component	proteasome complex
9	0000724	biological_process	double-strand break repair via homologous recombination
9	0005515	molecular_function	protein binding
9	0005576	cellular_component	extracellular region
9	0005634	cellular_component	nucleus
9	0005654	cellular_component	nucleoplasm
9	0005829	cellular_component	cytosol
9	0006281	biological_process	DNA repair
9	0006303	biological_process	double-strand break repair via nonhomologous end joining
9	0006508	biological_process	proteolysis
9	0006511	biological_process	ubiquitin-dependent protein catabolic process
9	0006974	biological_process	DNA damage response
9	0008233	molecular_function	peptidase activity
9	0008237	molecular_function	metallopeptidase activity
9	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
9	0016579	biological_process	protein deubiquitination
9	0016787	molecular_function	hydrolase activity
9	0022624	cellular_component	proteasome accessory complex
9	0031597	cellular_component	cytosolic proteasome complex
9	0034774	cellular_component	secretory granule lumen
9	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
9	0045471	biological_process	response to ethanol
9	0046872	molecular_function	metal ion binding
9	0061133	molecular_function	endopeptidase activator activity
9	0061136	biological_process	regulation of proteasomal protein catabolic process
9	0061578	molecular_function	K63-linked deubiquitinase activity
9	0070536	biological_process	protein K63-linked deubiquitination
9	0070628	molecular_function	proteasome binding
9	0140492	molecular_function	metal-dependent deubiquitinase activity
9	1904813	cellular_component	ficolin-1-rich granule lumen
AA	0000502	cellular_component	proteasome complex
AA	0003723	molecular_function	RNA binding
AA	0005515	molecular_function	protein binding
AA	0005634	cellular_component	nucleus
AA	0005654	cellular_component	nucleoplasm
AA	0005829	cellular_component	cytosol
AA	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AA	0022624	cellular_component	proteasome accessory complex
AA	0031593	molecular_function	polyubiquitin modification-dependent protein binding
AA	0042802	molecular_function	identical protein binding
AA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AA	0060090	molecular_function	molecular adaptor activity
AB	0000502	cellular_component	proteasome complex
AB	0000724	biological_process	double-strand break repair via homologous recombination
AB	0005515	molecular_function	protein binding
AB	0005634	cellular_component	nucleus
AB	0005654	cellular_component	nucleoplasm
AB	0005829	cellular_component	cytosol
AB	0006406	biological_process	mRNA export from nucleus
AB	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
AB	0032039	cellular_component	integrator complex
AB	0032991	cellular_component	protein-containing complex
AB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AB	0043248	biological_process	proteasome assembly
AC	0000502	cellular_component	proteasome complex
AC	0005515	molecular_function	protein binding
AC	0005576	cellular_component	extracellular region
AC	0005634	cellular_component	nucleus
AC	0005654	cellular_component	nucleoplasm
AC	0005829	cellular_component	cytosol
AC	0005838	cellular_component	proteasome regulatory particle
AC	0008540	cellular_component	proteasome regulatory particle, base subcomplex
AC	0016020	cellular_component	membrane
AC	0022624	cellular_component	proteasome accessory complex
AC	0030234	molecular_function	enzyme regulator activity
AC	0034515	cellular_component	proteasome storage granule
AC	0034774	cellular_component	secretory granule lumen
AC	0042176	biological_process	regulation of protein catabolic process
AC	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AC	0070062	cellular_component	extracellular exosome
AC	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0003723	molecular_function	RNA binding
B	0004175	molecular_function	endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0005840	cellular_component	ribosome
B	0005929	cellular_component	cilium
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0016363	cellular_component	nuclear matrix
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030016	cellular_component	myofibril
B	0030017	cellular_component	sarcomere
B	0035639	molecular_function	purine ribonucleoside triphosphate binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0050727	biological_process	regulation of inflammatory response
B	0051059	molecular_function	NF-kappaB binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0009615	biological_process	response to virus
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034774	cellular_component	secretory granule lumen
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000502	cellular_component	proteasome complex
D	0000932	cellular_component	P-body
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034774	cellular_component	secretory granule lumen
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000502	cellular_component	proteasome complex
G	0001530	molecular_function	lipopolysaccharide binding
G	0002376	biological_process	immune system process
G	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0000166	molecular_function	nucleotide binding
H	0000502	cellular_component	proteasome complex
H	0000932	cellular_component	P-body
H	0001649	biological_process	osteoblast differentiation
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0022624	cellular_component	proteasome accessory complex
H	0034774	cellular_component	secretory granule lumen
H	0036402	molecular_function	proteasome-activating activity
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000166	molecular_function	nucleotide binding
I	0000502	cellular_component	proteasome complex
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005838	cellular_component	proteasome regulatory particle
I	0008540	cellular_component	proteasome regulatory particle, base subcomplex
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0022624	cellular_component	proteasome accessory complex
I	0036402	molecular_function	proteasome-activating activity
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	1901800	biological_process	positive regulation of proteasomal protein catabolic process
J	0000166	molecular_function	nucleotide binding
J	0000502	cellular_component	proteasome complex
J	0005102	molecular_function	signaling receptor binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005838	cellular_component	proteasome regulatory particle
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0008134	molecular_function	transcription factor binding
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0016020	cellular_component	membrane
J	0016234	cellular_component	inclusion body
J	0016887	molecular_function	ATP hydrolysis activity
J	0017025	molecular_function	TBP-class protein binding
J	0022624	cellular_component	proteasome accessory complex
J	0031410	cellular_component	cytoplasmic vesicle
J	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
J	0031595	cellular_component	nuclear proteasome complex
J	0031597	cellular_component	cytosolic proteasome complex
J	0036402	molecular_function	proteasome-activating activity
J	0043069	biological_process	negative regulation of programmed cell death
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
J	0090261	biological_process	positive regulation of inclusion body assembly
J	0140296	molecular_function	general transcription initiation factor binding
J	0140297	molecular_function	DNA-binding transcription factor binding
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
K	0000166	molecular_function	nucleotide binding
K	0000502	cellular_component	proteasome complex
K	0001824	biological_process	blastocyst development
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0022624	cellular_component	proteasome accessory complex
K	0036064	cellular_component	ciliary basal body
K	0036402	molecular_function	proteasome-activating activity
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	1901800	biological_process	positive regulation of proteasomal protein catabolic process
L	0000166	molecular_function	nucleotide binding
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0008540	cellular_component	proteasome regulatory particle, base subcomplex
L	0016020	cellular_component	membrane
L	0016234	cellular_component	inclusion body
L	0016887	molecular_function	ATP hydrolysis activity
L	0022624	cellular_component	proteasome accessory complex
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031597	cellular_component	cytosolic proteasome complex
L	0036402	molecular_function	proteasome-activating activity
L	0036503	biological_process	ERAD pathway
L	0042802	molecular_function	identical protein binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0070062	cellular_component	extracellular exosome
L	0090261	biological_process	positive regulation of inclusion body assembly
L	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	0000166	molecular_function	nucleotide binding
M	0000502	cellular_component	proteasome complex
M	0000932	cellular_component	P-body
M	0001824	biological_process	blastocyst development
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0022624	cellular_component	proteasome accessory complex
M	0034774	cellular_component	secretory granule lumen
M	0036402	molecular_function	proteasome-activating activity
M	0042802	molecular_function	identical protein binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0043921	biological_process	host-mediated perturbation of viral transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0000502	cellular_component	proteasome complex
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005829	cellular_component	cytosol
N	0005838	cellular_component	proteasome regulatory particle
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0016020	cellular_component	membrane
N	0022624	cellular_component	proteasome accessory complex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0035578	cellular_component	azurophil granule lumen
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005829	cellular_component	cytosol
O	0005838	cellular_component	proteasome regulatory particle
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0007127	biological_process	meiosis I
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0016020	cellular_component	membrane
O	0022624	cellular_component	proteasome accessory complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005838	cellular_component	proteasome regulatory particle
P	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
P	0016020	cellular_component	membrane
P	0022624	cellular_component	proteasome accessory complex
P	0034774	cellular_component	secretory granule lumen
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0000502	cellular_component	proteasome complex
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005838	cellular_component	proteasome regulatory particle
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Q	0016020	cellular_component	membrane
Q	0022624	cellular_component	proteasome accessory complex
Q	0032991	cellular_component	protein-containing complex
Q	0034774	cellular_component	secretory granule lumen
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043248	biological_process	proteasome assembly
Q	0048863	biological_process	stem cell differentiation
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005654	cellular_component	nucleoplasm
R	0005829	cellular_component	cytosol
R	0005838	cellular_component	proteasome regulatory particle
R	0022624	cellular_component	proteasome accessory complex
R	0032991	cellular_component	protein-containing complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005829	cellular_component	cytosol
S	0005838	cellular_component	proteasome regulatory particle
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
S	0016020	cellular_component	membrane
S	0022624	cellular_component	proteasome accessory complex
S	0030234	molecular_function	enzyme regulator activity
S	0034774	cellular_component	secretory granule lumen
S	0042176	biological_process	regulation of protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005829	cellular_component	cytosol
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
T	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
T	0022624	cellular_component	proteasome accessory complex
T	0032991	cellular_component	protein-containing complex
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0016020	cellular_component	membrane
U	0034774	cellular_component	secretory granule lumen
U	0042803	molecular_function	protein homodimerization activity
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0140492	molecular_function	metal-dependent deubiquitinase activity
U	1904813	cellular_component	ficolin-1-rich granule lumen
V	0000502	cellular_component	proteasome complex
V	0000724	biological_process	double-strand break repair via homologous recombination
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006303	biological_process	double-strand break repair via nonhomologous end joining
V	0006508	biological_process	proteolysis
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0006974	biological_process	DNA damage response
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016579	biological_process	protein deubiquitination
V	0016787	molecular_function	hydrolase activity
V	0022624	cellular_component	proteasome accessory complex
V	0031597	cellular_component	cytosolic proteasome complex
V	0034774	cellular_component	secretory granule lumen
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0045471	biological_process	response to ethanol
V	0046872	molecular_function	metal ion binding
V	0061133	molecular_function	endopeptidase activator activity
V	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0061578	molecular_function	K63-linked deubiquitinase activity
V	0070536	biological_process	protein K63-linked deubiquitination
V	0070628	molecular_function	proteasome binding
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005829	cellular_component	cytosol
W	0008540	cellular_component	proteasome regulatory particle, base subcomplex
W	0022624	cellular_component	proteasome accessory complex
W	0031593	molecular_function	polyubiquitin modification-dependent protein binding
W	0042802	molecular_function	identical protein binding
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0060090	molecular_function	molecular adaptor activity
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0019773	cellular_component	proteasome core complex, alpha-subunit complex
X	0031625	molecular_function	ubiquitin protein ligase binding
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0032039	cellular_component	integrator complex
Y	0032991	cellular_component	protein-containing complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0005838	cellular_component	proteasome regulatory particle
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0016020	cellular_component	membrane
Z	0022624	cellular_component	proteasome accessory complex
Z	0030234	molecular_function	enzyme regulator activity
Z	0034515	cellular_component	proteasome storage granule
Z	0034774	cellular_component	secretory granule lumen
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	1904813	cellular_component	ficolin-1-rich granule lumen
a	0000502	cellular_component	proteasome complex
a	0004175	molecular_function	endopeptidase activity
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0006508	biological_process	proteolysis
a	0008233	molecular_function	peptidase activity
a	0016787	molecular_function	hydrolase activity
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0045296	molecular_function	cadherin binding
a	0051603	biological_process	proteolysis involved in protein catabolic process
a	0070062	cellular_component	extracellular exosome
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0005929	cellular_component	cilium
b	0006508	biological_process	proteolysis
b	0008233	molecular_function	peptidase activity
b	0016604	cellular_component	nuclear body
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0034774	cellular_component	secretory granule lumen
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
b	1904813	cellular_component	ficolin-1-rich granule lumen
c	0000502	cellular_component	proteasome complex
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0019774	cellular_component	proteasome core complex, beta-subunit complex
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0051603	biological_process	proteolysis involved in protein catabolic process
c	0070062	cellular_component	extracellular exosome
d	0000502	cellular_component	proteasome complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005839	cellular_component	proteasome core complex
d	0010498	biological_process	proteasomal protein catabolic process
d	0016020	cellular_component	membrane
d	0019774	cellular_component	proteasome core complex, beta-subunit complex
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	proteolysis involved in protein catabolic process
d	0070062	cellular_component	extracellular exosome
e	0000502	cellular_component	proteasome complex
e	0004175	molecular_function	endopeptidase activity
e	0004298	molecular_function	threonine-type endopeptidase activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005813	cellular_component	centrosome
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006508	biological_process	proteolysis
e	0006979	biological_process	response to oxidative stress
e	0008233	molecular_function	peptidase activity
e	0016787	molecular_function	hydrolase activity
e	0019774	cellular_component	proteasome core complex, beta-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043248	biological_process	proteasome assembly
e	0051603	biological_process	proteolysis involved in protein catabolic process
e	0070062	cellular_component	extracellular exosome
f	0000502	cellular_component	proteasome complex
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005839	cellular_component	proteasome core complex
f	0019774	cellular_component	proteasome core complex, beta-subunit complex
f	0034774	cellular_component	secretory granule lumen
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	proteolysis involved in protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	1904813	cellular_component	ficolin-1-rich granule lumen
g	0000502	cellular_component	proteasome complex
g	0001530	molecular_function	lipopolysaccharide binding
g	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0019774	cellular_component	proteasome core complex, beta-subunit complex
g	0036064	cellular_component	ciliary basal body
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0051603	biological_process	proteolysis involved in protein catabolic process
g	0070062	cellular_component	extracellular exosome
h	0000502	cellular_component	proteasome complex
h	0000932	cellular_component	P-body
h	0003723	molecular_function	RNA binding
h	0004175	molecular_function	endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005737	cellular_component	cytoplasm
h	0005739	cellular_component	mitochondrion
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0005840	cellular_component	ribosome
h	0005929	cellular_component	cilium
h	0006511	biological_process	ubiquitin-dependent protein catabolic process
h	0016363	cellular_component	nuclear matrix
h	0019773	cellular_component	proteasome core complex, alpha-subunit complex
h	0030016	cellular_component	myofibril
h	0030017	cellular_component	sarcomere
h	0035639	molecular_function	purine ribonucleoside triphosphate binding
h	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0050727	biological_process	regulation of inflammatory response
h	0051059	molecular_function	NF-kappaB binding
h	0051603	biological_process	proteolysis involved in protein catabolic process
h	0070062	cellular_component	extracellular exosome
i	0000502	cellular_component	proteasome complex
i	0000932	cellular_component	P-body
i	0005515	molecular_function	protein binding
i	0005576	cellular_component	extracellular region
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
i	0009615	biological_process	response to virus
i	0019773	cellular_component	proteasome core complex, alpha-subunit complex
i	0034774	cellular_component	secretory granule lumen
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0051603	biological_process	proteolysis involved in protein catabolic process
i	0070062	cellular_component	extracellular exosome
i	1904813	cellular_component	ficolin-1-rich granule lumen
j	0000502	cellular_component	proteasome complex
j	0000932	cellular_component	P-body
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0006511	biological_process	ubiquitin-dependent protein catabolic process
j	0019773	cellular_component	proteasome core complex, alpha-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
j	0070062	cellular_component	extracellular exosome
k	0000502	cellular_component	proteasome complex
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0006511	biological_process	ubiquitin-dependent protein catabolic process
k	0019773	cellular_component	proteasome core complex, alpha-subunit complex
k	0042802	molecular_function	identical protein binding
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
k	0070062	cellular_component	extracellular exosome
l	0000502	cellular_component	proteasome complex
l	0005515	molecular_function	protein binding
l	0005576	cellular_component	extracellular region
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0006511	biological_process	ubiquitin-dependent protein catabolic process
l	0019773	cellular_component	proteasome core complex, alpha-subunit complex
l	0034774	cellular_component	secretory granule lumen
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0051603	biological_process	proteolysis involved in protein catabolic process
l	0070062	cellular_component	extracellular exosome
l	1904813	cellular_component	ficolin-1-rich granule lumen
m	0000502	cellular_component	proteasome complex
m	0001530	molecular_function	lipopolysaccharide binding
m	0002376	biological_process	immune system process
m	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005737	cellular_component	cytoplasm
m	0005813	cellular_component	centrosome
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0006511	biological_process	ubiquitin-dependent protein catabolic process
m	0019773	cellular_component	proteasome core complex, alpha-subunit complex
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	proteolysis involved in protein catabolic process
m	0070062	cellular_component	extracellular exosome
n	0000502	cellular_component	proteasome complex
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0006511	biological_process	ubiquitin-dependent protein catabolic process
n	0019773	cellular_component	proteasome core complex, alpha-subunit complex
n	0031625	molecular_function	ubiquitin protein ligase binding
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0051603	biological_process	proteolysis involved in protein catabolic process
n	0070062	cellular_component	extracellular exosome
o	0000502	cellular_component	proteasome complex
o	0004175	molecular_function	endopeptidase activity
o	0004298	molecular_function	threonine-type endopeptidase activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005737	cellular_component	cytoplasm
o	0005739	cellular_component	mitochondrion
o	0005829	cellular_component	cytosol
o	0005839	cellular_component	proteasome core complex
o	0006508	biological_process	proteolysis
o	0008233	molecular_function	peptidase activity
o	0016787	molecular_function	hydrolase activity
o	0019774	cellular_component	proteasome core complex, beta-subunit complex
o	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
o	0045296	molecular_function	cadherin binding
o	0051603	biological_process	proteolysis involved in protein catabolic process
o	0070062	cellular_component	extracellular exosome
p	0000502	cellular_component	proteasome complex
p	0004175	molecular_function	endopeptidase activity
p	0004298	molecular_function	threonine-type endopeptidase activity
p	0005515	molecular_function	protein binding
p	0005576	cellular_component	extracellular region
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0005839	cellular_component	proteasome core complex
p	0005929	cellular_component	cilium
p	0006508	biological_process	proteolysis
p	0008233	molecular_function	peptidase activity
p	0016604	cellular_component	nuclear body
p	0016787	molecular_function	hydrolase activity
p	0019774	cellular_component	proteasome core complex, beta-subunit complex
p	0034774	cellular_component	secretory granule lumen
p	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
p	0051603	biological_process	proteolysis involved in protein catabolic process
p	1904813	cellular_component	ficolin-1-rich granule lumen
q	0000502	cellular_component	proteasome complex
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005829	cellular_component	cytosol
q	0005839	cellular_component	proteasome core complex
q	0019774	cellular_component	proteasome core complex, beta-subunit complex
q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
q	0051603	biological_process	proteolysis involved in protein catabolic process
q	0070062	cellular_component	extracellular exosome
r	0000502	cellular_component	proteasome complex
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0005839	cellular_component	proteasome core complex
r	0010498	biological_process	proteasomal protein catabolic process
r	0016020	cellular_component	membrane
r	0019774	cellular_component	proteasome core complex, beta-subunit complex
r	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
r	0051603	biological_process	proteolysis involved in protein catabolic process
r	0070062	cellular_component	extracellular exosome
s	0000502	cellular_component	proteasome complex
s	0004175	molecular_function	endopeptidase activity
s	0004298	molecular_function	threonine-type endopeptidase activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005737	cellular_component	cytoplasm
s	0005813	cellular_component	centrosome
s	0005829	cellular_component	cytosol
s	0005839	cellular_component	proteasome core complex
s	0006508	biological_process	proteolysis
s	0006979	biological_process	response to oxidative stress
s	0008233	molecular_function	peptidase activity
s	0016787	molecular_function	hydrolase activity
s	0019774	cellular_component	proteasome core complex, beta-subunit complex
s	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
s	0043248	biological_process	proteasome assembly
s	0051603	biological_process	proteolysis involved in protein catabolic process
s	0070062	cellular_component	extracellular exosome
t	0000502	cellular_component	proteasome complex
t	0005515	molecular_function	protein binding
t	0005576	cellular_component	extracellular region
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005737	cellular_component	cytoplasm
t	0005829	cellular_component	cytosol
t	0005839	cellular_component	proteasome core complex
t	0019774	cellular_component	proteasome core complex, beta-subunit complex
t	0034774	cellular_component	secretory granule lumen
t	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
t	0051603	biological_process	proteolysis involved in protein catabolic process
t	0070062	cellular_component	extracellular exosome
t	1904813	cellular_component	ficolin-1-rich granule lumen
u	0000502	cellular_component	proteasome complex
u	0001530	molecular_function	lipopolysaccharide binding
u	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005737	cellular_component	cytoplasm
u	0005739	cellular_component	mitochondrion
u	0005829	cellular_component	cytosol
u	0005839	cellular_component	proteasome core complex
u	0019774	cellular_component	proteasome core complex, beta-subunit complex
u	0036064	cellular_component	ciliary basal body
u	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
u	0051603	biological_process	proteolysis involved in protein catabolic process
u	0070062	cellular_component	extracellular exosome
v	0000166	molecular_function	nucleotide binding
v	0000502	cellular_component	proteasome complex
v	0000932	cellular_component	P-body
v	0001649	biological_process	osteoblast differentiation
v	0005515	molecular_function	protein binding
v	0005524	molecular_function	ATP binding
v	0005576	cellular_component	extracellular region
v	0005634	cellular_component	nucleus
v	0005654	cellular_component	nucleoplasm
v	0005737	cellular_component	cytoplasm
v	0005829	cellular_component	cytosol
v	0006511	biological_process	ubiquitin-dependent protein catabolic process
v	0008540	cellular_component	proteasome regulatory particle, base subcomplex
v	0016020	cellular_component	membrane
v	0016887	molecular_function	ATP hydrolysis activity
v	0022624	cellular_component	proteasome accessory complex
v	0034774	cellular_component	secretory granule lumen
v	0036402	molecular_function	proteasome-activating activity
v	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
v	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
v	1901800	biological_process	positive regulation of proteasomal protein catabolic process
v	1904813	cellular_component	ficolin-1-rich granule lumen
w	0000166	molecular_function	nucleotide binding
w	0000502	cellular_component	proteasome complex
w	0003723	molecular_function	RNA binding
w	0005515	molecular_function	protein binding
w	0005524	molecular_function	ATP binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005737	cellular_component	cytoplasm
w	0005829	cellular_component	cytosol
w	0005838	cellular_component	proteasome regulatory particle
w	0008540	cellular_component	proteasome regulatory particle, base subcomplex
w	0016020	cellular_component	membrane
w	0016887	molecular_function	ATP hydrolysis activity
w	0022624	cellular_component	proteasome accessory complex
w	0036402	molecular_function	proteasome-activating activity
w	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
w	1901800	biological_process	positive regulation of proteasomal protein catabolic process
x	0000166	molecular_function	nucleotide binding
x	0000502	cellular_component	proteasome complex
x	0005102	molecular_function	signaling receptor binding
x	0005515	molecular_function	protein binding
x	0005524	molecular_function	ATP binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005737	cellular_component	cytoplasm
x	0005829	cellular_component	cytosol
x	0005838	cellular_component	proteasome regulatory particle
x	0006357	biological_process	regulation of transcription by RNA polymerase II
x	0008134	molecular_function	transcription factor binding
x	0008540	cellular_component	proteasome regulatory particle, base subcomplex
x	0016020	cellular_component	membrane
x	0016234	cellular_component	inclusion body
x	0016887	molecular_function	ATP hydrolysis activity
x	0017025	molecular_function	TBP-class protein binding
x	0022624	cellular_component	proteasome accessory complex
x	0031410	cellular_component	cytoplasmic vesicle
x	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
x	0031595	cellular_component	nuclear proteasome complex
x	0031597	cellular_component	cytosolic proteasome complex
x	0036402	molecular_function	proteasome-activating activity
x	0043069	biological_process	negative regulation of programmed cell death
x	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
x	0045892	biological_process	negative regulation of DNA-templated transcription
x	0045893	biological_process	positive regulation of DNA-templated transcription
x	0070062	cellular_component	extracellular exosome
x	0072562	cellular_component	blood microparticle
x	0090261	biological_process	positive regulation of inclusion body assembly
x	0140296	molecular_function	general transcription initiation factor binding
x	0140297	molecular_function	DNA-binding transcription factor binding
x	1901800	biological_process	positive regulation of proteasomal protein catabolic process
y	0000166	molecular_function	nucleotide binding
y	0000502	cellular_component	proteasome complex
y	0001824	biological_process	blastocyst development
y	0005515	molecular_function	protein binding
y	0005524	molecular_function	ATP binding
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005737	cellular_component	cytoplasm
y	0005829	cellular_component	cytosol
y	0006508	biological_process	proteolysis
y	0008540	cellular_component	proteasome regulatory particle, base subcomplex
y	0016020	cellular_component	membrane
y	0016887	molecular_function	ATP hydrolysis activity
y	0022624	cellular_component	proteasome accessory complex
y	0036064	cellular_component	ciliary basal body
y	0036402	molecular_function	proteasome-activating activity
y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
y	1901800	biological_process	positive regulation of proteasomal protein catabolic process
z	0000166	molecular_function	nucleotide binding
z	0000502	cellular_component	proteasome complex
z	0005515	molecular_function	protein binding
z	0005524	molecular_function	ATP binding
z	0005634	cellular_component	nucleus
z	0005654	cellular_component	nucleoplasm
z	0005737	cellular_component	cytoplasm
z	0005829	cellular_component	cytosol
z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
z	0016020	cellular_component	membrane
z	0016234	cellular_component	inclusion body
z	0016887	molecular_function	ATP hydrolysis activity
z	0022624	cellular_component	proteasome accessory complex
z	0030674	molecular_function	protein-macromolecule adaptor activity
z	0031597	cellular_component	cytosolic proteasome complex
z	0036402	molecular_function	proteasome-activating activity
z	0036503	biological_process	ERAD pathway
z	0042802	molecular_function	identical protein binding
z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
z	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
z	0070062	cellular_component	extracellular exosome
z	0090261	biological_process	positive regulation of inclusion body assembly
z	1901800	biological_process	positive regulation of proteasomal protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ADP I 501

Chain	Residue
I	ASP186
I	LYS237
I	ASN332
I	ILE364
I	HIS368
I	GLY392
I	ALA393
J	ARG307
J	ARG310
I	ILE187
I	GLY188
I	PRO228
I	GLY229
I	GLY231
I	LYS232
I	THR233
I	LEU234

---

site_id	AC2
Number of Residues	14
Details	binding site for residue ADP H 501

Chain	Residue
H	ASP176
H	GLY178
H	PRO218
H	GLY219
H	THR220
H	GLY221
H	LYS222
H	THR223
H	LEU224
H	GLY382
H	ALA383
I	ASP317
I	ARG343
I	ARG346

---

site_id	AC3
Number of Residues	14
Details	binding site for residue ADP L 401

Chain	Residue
L	GLY136
L	GLY177
L	GLY179
L	LYS180
L	THR181
L	LEU182
L	ASN280
L	ILE312
L	HIS316
L	GLY340
L	ALA341
L	ARG344
M	ARG344
M	ARG347

---

site_id	AC4
Number of Residues	14
Details	binding site for residue ADP M 501

Chain	Residue
H	ARG333
M	ILE188
M	GLY189
M	PRO229
M	GLY230
M	THR231
M	GLY232
M	LYS233
M	THR234
M	LEU235
M	ASN333
M	ILE365
M	HIS369
M	LYS397

---

site_id	AC5
Number of Residues	13
Details	binding site for residue ADP J 501

Chain	Residue
J	ILE151
J	GLY152
J	LEU154
J	PRO192
J	GLY193
J	THR194
J	GLY195
J	LYS196
J	THR197
J	ILE328
J	HIS332
J	GLY356
J	LYS360

---

site_id	AC6
Number of Residues	14
Details	binding site for residue ADP K 501

Chain	Residue
K	ASP166
K	ILE167
K	GLY168
K	GLY209
K	CYS210
K	GLY211
K	LYS212
K	THR213
K	MET214
K	ILE344
K	GLY372
K	ALA373
L	ARG291
L	ARG294

---

site_id	AC7
Number of Residues	14
Details	binding site for residue ADP v 501

Chain	Residue
w	ARG346
v	ASP176
v	GLY178
v	PRO218
v	GLY219
v	THR220
v	GLY221
v	LYS222
v	THR223
v	LEU224
v	GLY382
v	ALA383
w	ASP317
w	ARG343

---

site_id	AC8
Number of Residues	17
Details	binding site for residue ADP w 501

Chain	Residue
w	ASP186
w	ILE187
w	GLY188
w	PRO228
w	GLY229
w	GLY231
w	LYS232
w	THR233
w	LEU234
w	LYS237
w	ASN332
w	ILE364
w	HIS368
w	GLY392
w	ALA393
x	ARG307
x	ARG310

---

site_id	AC9
Number of Residues	13
Details	binding site for residue ADP x 501

Chain	Residue
x	ILE151
x	GLY152
x	LEU154
x	PRO192
x	GLY193
x	THR194
x	GLY195
x	LYS196
x	THR197
x	ILE328
x	HIS332
x	GLY356
x	LYS360

---

site_id	AD1
Number of Residues	14
Details	binding site for residue ADP y 501

Chain	Residue
y	ASP166
y	ILE167
y	GLY168
y	GLY209
y	CYS210
y	GLY211
y	LYS212
y	THR213
y	MET214
y	ILE344
y	GLY372
y	ALA373
z	ARG291
z	ARG294

---

site_id	AD2
Number of Residues	14
Details	binding site for residue ADP z 401

Chain	Residue
0	ARG344
0	ARG347
z	GLY136
z	GLY177
z	GLY179
z	LYS180
z	THR181
z	LEU182
z	ASN280
z	ILE312
z	HIS316
z	GLY340
z	ALA341
z	ARG344

---

site_id	AD3
Number of Residues	14
Details	binding site for residue ADP 0 501

Chain	Residue
0	ILE188
0	GLY189
0	PRO229
0	GLY230
0	THR231
0	GLY232
0	LYS233
0	THR234
0	LEU235
0	ASN333
0	ILE365
0	HIS369
0	LYS397
v	ARG333

---

site_id	AD4
Number of Residues	10
Details	binding site for Di-peptide ILE 8 91 and CYS 8 116

Chain	Residue
8	LEU39
8	LEU40
8	TYR79
8	ARG90
8	VAL92
8	MET112
8	LYS113
8	ARG114
8	TYR115
8	PRO117

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
7	ALA72-VAL87

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA

Chain	Residue	Details
k	TYR3-ALA25
l	TYR8-ALA30
i	TYR5-ALA27
n	TYR7-ALA29
j	TYR5-ALA27
m	TYR6-ALA28
h	PHE9-ALA31

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkVImATNridiLDsALl.R

Chain	Residue	Details
J	ILE289-ARG307
I	VAL325-ARG343
K	VAL305-ARG323
L	VAL273-ARG291
M	VAL326-ARG344
H	ILE315-ARG333

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGVkFegGVVIAADmlgsygslarfrnis.RimrvnnstmlgasGdyAD

Chain	Residue	Details
g	LEU12-ASP59
b	ALA4-ASP51
c	MET12-ASP59
j	LEU35-ASP82
f	LEU13-ASP60
d	ILE5-ASP52
o	MET4-ASP51
e	LEU4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	132
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	138
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	136
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	136
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	124
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	132
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	94
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	68
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	80
Details	Repeat: {"description":"PC 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3TXS7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1702
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2004","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Potts A.","Brablan J.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	48
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	26
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	366
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	10
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---