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5GIE

Crystal structure of VDR in complex with DLAM-4P (P21 form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0006355biological_processregulation of DNA-templated transcription
D0003677molecular_functionDNA binding
D0004879molecular_functionnuclear receptor activity
D0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue VDP A 501
ChainResidue
ATYR143
AVAL296
ASER297
AHIS393
ATYR397
APHE418
APRO219
ASER233
AILE267
AARG270
ASER271
ASER274
ATRP282
ACYS284

site_idAC2
Number of Residues14
Detailsbinding site for residue VDP D 501
ChainResidue
DTYR143
DLEU223
DSER233
DILE267
DARG270
DSER271
DSER274
DTRP282
DCYS284
DVAL296
DLEU305
DHIS393
DTYR397
DLEU400

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsRegion: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RK3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsMotif: {"description":"LXXLL motif 2"}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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