5FV9
Crystal structure of GalNAc-T2 in complex with compound 16d
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0005795 | cellular_component | Golgi stack |
A | 0006486 | biological_process | protein glycosylation |
A | 0006493 | biological_process | protein O-linked glycosylation |
A | 0016020 | cellular_component | membrane |
A | 0016266 | biological_process | O-glycan processing |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0018242 | biological_process | protein O-linked glycosylation via serine |
A | 0018243 | biological_process | protein O-linked glycosylation via threonine |
A | 0030145 | molecular_function | manganese ion binding |
A | 0030246 | molecular_function | carbohydrate binding |
A | 0032580 | cellular_component | Golgi cisterna membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0051604 | biological_process | protein maturation |
B | 0000139 | cellular_component | Golgi membrane |
B | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0005794 | cellular_component | Golgi apparatus |
B | 0005795 | cellular_component | Golgi stack |
B | 0006486 | biological_process | protein glycosylation |
B | 0006493 | biological_process | protein O-linked glycosylation |
B | 0016020 | cellular_component | membrane |
B | 0016266 | biological_process | O-glycan processing |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0018242 | biological_process | protein O-linked glycosylation via serine |
B | 0018243 | biological_process | protein O-linked glycosylation via threonine |
B | 0030145 | molecular_function | manganese ion binding |
B | 0030246 | molecular_function | carbohydrate binding |
B | 0032580 | cellular_component | Golgi cisterna membrane |
B | 0046872 | molecular_function | metal ion binding |
B | 0048471 | cellular_component | perinuclear region of cytoplasm |
B | 0051604 | biological_process | protein maturation |
C | 0000139 | cellular_component | Golgi membrane |
C | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005789 | cellular_component | endoplasmic reticulum membrane |
C | 0005794 | cellular_component | Golgi apparatus |
C | 0005795 | cellular_component | Golgi stack |
C | 0006486 | biological_process | protein glycosylation |
C | 0006493 | biological_process | protein O-linked glycosylation |
C | 0016020 | cellular_component | membrane |
C | 0016266 | biological_process | O-glycan processing |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0018242 | biological_process | protein O-linked glycosylation via serine |
C | 0018243 | biological_process | protein O-linked glycosylation via threonine |
C | 0030145 | molecular_function | manganese ion binding |
C | 0030246 | molecular_function | carbohydrate binding |
C | 0032580 | cellular_component | Golgi cisterna membrane |
C | 0046872 | molecular_function | metal ion binding |
C | 0048471 | cellular_component | perinuclear region of cytoplasm |
C | 0051604 | biological_process | protein maturation |
D | 0000139 | cellular_component | Golgi membrane |
D | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005789 | cellular_component | endoplasmic reticulum membrane |
D | 0005794 | cellular_component | Golgi apparatus |
D | 0005795 | cellular_component | Golgi stack |
D | 0006486 | biological_process | protein glycosylation |
D | 0006493 | biological_process | protein O-linked glycosylation |
D | 0016020 | cellular_component | membrane |
D | 0016266 | biological_process | O-glycan processing |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0018242 | biological_process | protein O-linked glycosylation via serine |
D | 0018243 | biological_process | protein O-linked glycosylation via threonine |
D | 0030145 | molecular_function | manganese ion binding |
D | 0030246 | molecular_function | carbohydrate binding |
D | 0032580 | cellular_component | Golgi cisterna membrane |
D | 0046872 | molecular_function | metal ion binding |
D | 0048471 | cellular_component | perinuclear region of cytoplasm |
D | 0051604 | biological_process | protein maturation |
E | 0000139 | cellular_component | Golgi membrane |
E | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005576 | cellular_component | extracellular region |
E | 0005789 | cellular_component | endoplasmic reticulum membrane |
E | 0005794 | cellular_component | Golgi apparatus |
E | 0005795 | cellular_component | Golgi stack |
E | 0006486 | biological_process | protein glycosylation |
E | 0006493 | biological_process | protein O-linked glycosylation |
E | 0016020 | cellular_component | membrane |
E | 0016266 | biological_process | O-glycan processing |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0018242 | biological_process | protein O-linked glycosylation via serine |
E | 0018243 | biological_process | protein O-linked glycosylation via threonine |
E | 0030145 | molecular_function | manganese ion binding |
E | 0030246 | molecular_function | carbohydrate binding |
E | 0032580 | cellular_component | Golgi cisterna membrane |
E | 0046872 | molecular_function | metal ion binding |
E | 0048471 | cellular_component | perinuclear region of cytoplasm |
E | 0051604 | biological_process | protein maturation |
F | 0000139 | cellular_component | Golgi membrane |
F | 0004653 | molecular_function | polypeptide N-acetylgalactosaminyltransferase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005576 | cellular_component | extracellular region |
F | 0005789 | cellular_component | endoplasmic reticulum membrane |
F | 0005794 | cellular_component | Golgi apparatus |
F | 0005795 | cellular_component | Golgi stack |
F | 0006486 | biological_process | protein glycosylation |
F | 0006493 | biological_process | protein O-linked glycosylation |
F | 0016020 | cellular_component | membrane |
F | 0016266 | biological_process | O-glycan processing |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0018242 | biological_process | protein O-linked glycosylation via serine |
F | 0018243 | biological_process | protein O-linked glycosylation via threonine |
F | 0030145 | molecular_function | manganese ion binding |
F | 0030246 | molecular_function | carbohydrate binding |
F | 0032580 | cellular_component | Golgi cisterna membrane |
F | 0046872 | molecular_function | metal ion binding |
F | 0048471 | cellular_component | perinuclear region of cytoplasm |
F | 0051604 | biological_process | protein maturation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE UDP A 1570 |
Chain | Residue |
A | THR143 |
A | ARG362 |
A | MN1571 |
A | HOH2084 |
A | HOH2164 |
A | HOH2166 |
A | HIS145 |
A | ASP176 |
A | ARG201 |
A | LEU204 |
A | ASP224 |
A | HIS226 |
A | VAL330 |
A | HIS359 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 1571 |
Chain | Residue |
A | ASP224 |
A | HIS226 |
A | HIS359 |
A | UDP1570 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 1572 |
Chain | Residue |
A | GLY535 |
A | SER536 |
A | ASN537 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 1573 |
Chain | Residue |
A | TYR177 |
A | SER178 |
A | ASN179 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1575 |
Chain | Residue |
A | TYR99 |
A | LYS103 |
A | HOH2024 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE Y6W B 1570 |
Chain | Residue |
B | THR143 |
B | HIS145 |
B | ASP176 |
B | ARG201 |
B | LEU204 |
B | SER207 |
B | ASP224 |
B | HIS226 |
B | VAL330 |
B | GLU334 |
B | ARG362 |
B | MN1571 |
B | UDP1572 |
B | HOH2168 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 1571 |
Chain | Residue |
B | ASP224 |
B | HIS226 |
B | HIS359 |
B | Y6W1570 |
B | UDP1572 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UDP B 1572 |
Chain | Residue |
B | THR143 |
B | PHE144 |
B | HIS145 |
B | ASP176 |
B | ARG201 |
B | LEU204 |
B | ASP224 |
B | HIS226 |
B | HIS359 |
B | ARG362 |
B | Y6W1570 |
B | MN1571 |
B | HOH2051 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 1573 |
Chain | Residue |
B | TYR408 |
B | GLY409 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 1574 |
Chain | Residue |
B | GLU481 |
B | ALA483 |
B | LYS491 |
B | MET493 |
site_id | BC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE UDP C 1570 |
Chain | Residue |
C | THR143 |
C | HIS145 |
C | ASP176 |
C | ARG201 |
C | LEU204 |
C | SER207 |
C | ASP224 |
C | HIS226 |
C | VAL330 |
C | HIS359 |
C | ARG362 |
C | MN1571 |
C | HOH2058 |
C | HOH2059 |
C | HOH2132 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN C 1571 |
Chain | Residue |
C | ASP224 |
C | HIS226 |
C | HIS359 |
C | UDP1570 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO C 1572 |
Chain | Residue |
C | LYS271 |
C | LYS302 |
C | VAL433 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO C 1573 |
Chain | Residue |
C | ASP517 |
C | SER518 |
C | ARG519 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL C 1574 |
Chain | Residue |
C | TYR408 |
C | GLY409 |
C | HOH2303 |
C | HOH2304 |
F | GLN412 |
site_id | BC7 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE UDP D 1555 |
Chain | Residue |
D | ARG201 |
D | GLY203 |
D | LEU204 |
D | SER207 |
D | ASP224 |
D | HIS226 |
D | VAL330 |
D | GLU334 |
D | HIS359 |
D | ARG362 |
D | MN1556 |
D | HOH2055 |
D | HOH2180 |
D | THR143 |
D | PHE144 |
D | HIS145 |
D | ASP176 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN D 1556 |
Chain | Residue |
D | ASP224 |
D | HIS226 |
D | HIS359 |
D | UDP1555 |
site_id | BC9 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UDP E 1570 |
Chain | Residue |
E | THR143 |
E | HIS145 |
E | ASP176 |
E | ARG201 |
E | LEU204 |
E | SER207 |
E | ASP224 |
E | HIS226 |
E | VAL330 |
E | HIS359 |
E | ARG362 |
E | MN1571 |
E | Y6W1572 |
E | HOH2053 |
E | HOH2054 |
E | HOH2121 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN E 1571 |
Chain | Residue |
E | ASP224 |
E | HIS226 |
E | HIS359 |
E | UDP1570 |
E | Y6W1572 |
site_id | CC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE Y6W E 1572 |
Chain | Residue |
E | THR143 |
E | PHE144 |
E | HIS145 |
E | ASP176 |
E | ARG201 |
E | SER207 |
E | HIS226 |
E | VAL330 |
E | GLU334 |
E | ARG362 |
E | UDP1570 |
E | MN1571 |
E | HOH2109 |
E | HOH2181 |
site_id | CC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO E 1573 |
Chain | Residue |
A | HOH2158 |
E | ASN198 |
E | ASP199 |
E | ARG200 |
E | GLU202 |
E | ARG210 |
E | HOH2101 |
site_id | CC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO E 1574 |
Chain | Residue |
E | TRP343 |
E | ASN432 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO E 1575 |
Chain | Residue |
E | TYR177 |
E | SER178 |
E | ASN179 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO E 1576 |
Chain | Residue |
E | GLU481 |
E | LYS491 |
E | HIS492 |
E | MET493 |
site_id | CC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE UDP F 1570 |
Chain | Residue |
F | THR143 |
F | PHE144 |
F | HIS145 |
F | ASP176 |
F | ARG201 |
F | LEU204 |
F | ASP224 |
F | HIS226 |
F | HIS359 |
F | ARG362 |
F | MN1571 |
F | Y6W1572 |
F | HOH2063 |
site_id | CC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN F 1571 |
Chain | Residue |
F | ASP224 |
F | HIS226 |
F | HIS359 |
F | UDP1570 |
F | Y6W1572 |
site_id | CC9 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE Y6W F 1572 |
Chain | Residue |
F | THR143 |
F | PHE144 |
F | ASP176 |
F | ARG201 |
F | ASP224 |
F | HIS226 |
F | VAL330 |
F | GLU334 |
F | ARG362 |
F | UDP1570 |
F | MN1571 |
F | HOH2097 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 1573 |
Chain | Residue |
F | ARG502 |
F | SER536 |
F | ASN537 |
F | HOH2199 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 1574 |
Chain | Residue |
F | PRO407 |
F | TYR408 |
F | GLY409 |
F | HOH2200 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO F 1575 |
Chain | Residue |
F | ARG514 |
F | ASP517 |
F | SER518 |
F | ARG519 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL F 1576 |
Chain | Residue |
F | ASP199 |
F | GLU202 |
F | ARG210 |
F | HOH2202 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL F 1577 |
Chain | Residue |
E | ARG514 |
E | ASP517 |
E | ARG519 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 30 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | MET1-ARG6 | |
B | MET1-ARG6 | |
C | MET1-ARG6 | |
D | MET1-ARG6 | |
E | MET1-ARG6 | |
F | MET1-ARG6 |
site_id | SWS_FT_FI2 |
Number of Residues | 102 |
Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
Chain | Residue | Details |
A | MET7-TYR24 | |
B | MET7-TYR24 | |
C | MET7-TYR24 | |
D | MET7-TYR24 | |
E | MET7-TYR24 | |
F | MET7-TYR24 |
site_id | SWS_FT_FI3 |
Number of Residues | 3276 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
A | SER25-GLN571 | |
B | SER25-GLN571 | |
C | SER25-GLN571 | |
D | SER25-GLN571 | |
E | SER25-GLN571 | |
F | SER25-GLN571 |
site_id | SWS_FT_FI4 |
Number of Residues | 42 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
Chain | Residue | Details |
A | THR143 | |
B | ARG201 | |
B | SER225 | |
B | TRP331 | |
B | ARG362 | |
B | HIS365 | |
C | THR143 | |
C | ASP176 | |
C | ARG201 | |
C | SER225 | |
C | TRP331 | |
A | ASP176 | |
C | ARG362 | |
C | HIS365 | |
D | THR143 | |
D | ASP176 | |
D | ARG201 | |
D | SER225 | |
D | TRP331 | |
D | ARG362 | |
D | HIS365 | |
E | THR143 | |
A | ARG201 | |
E | ASP176 | |
E | ARG201 | |
E | SER225 | |
E | TRP331 | |
E | ARG362 | |
E | HIS365 | |
F | THR143 | |
F | ASP176 | |
F | ARG201 | |
F | SER225 | |
A | SER225 | |
F | TRP331 | |
F | ARG362 | |
F | HIS365 | |
A | TRP331 | |
A | ARG362 | |
A | HIS365 | |
B | THR143 | |
B | ASP176 |
site_id | SWS_FT_FI5 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
Chain | Residue | Details |
A | ASP224 | |
D | ASP224 | |
D | HIS226 | |
D | HIS359 | |
E | ASP224 | |
E | HIS226 | |
E | HIS359 | |
F | ASP224 | |
F | HIS226 | |
F | HIS359 | |
A | HIS226 | |
A | HIS359 | |
B | ASP224 | |
B | HIS226 | |
B | HIS359 | |
C | ASP224 | |
C | HIS226 | |
C | HIS359 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJN, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9, ECO:0007744|PDB:5NDF, ECO:0007744|PDB:6EGS |
Chain | Residue | Details |
A | TYR367 | |
B | TYR367 | |
C | TYR367 | |
D | TYR367 | |
E | TYR367 | |
F | TYR367 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Not glycosylated |
Chain | Residue | Details |
A | ASP516 | |
B | ASP516 | |
C | ASP516 | |
D | ASP516 | |
E | ASP516 | |
F | ASP516 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER536 | |
B | SER536 | |
C | SER536 | |
D | SER536 | |
E | SER536 | |
F | SER536 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:37453717 |
Chain | Residue | Details |
A | SER29 | |
B | SER29 | |
C | SER29 | |
D | SER29 | |
E | SER29 | |
F | SER29 |