5NDF
Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Summary for 5NDF
Entry DOI | 10.2210/pdb5ndf/pdb |
Descriptor | Polypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | galnac-t2 inhibition flavonoids mucin-type o-glycosylation alzheimer disease, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein : Q10471 |
Total number of polymer chains | 6 |
Total formula weight | 393182.20 |
Authors | Hurtado-Guerrero, R.,De las Rivas, M. (deposition date: 2017-03-08, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Liu, F.,Xu, K.,Xu, Z.,de Las Rivas, M.,Wang, C.,Li, X.,Lu, J.,Zhou, Y.,Delso, I.,Merino, P.,Hurtado-Guerrero, R.,Zhang, Y.,Wu, F. The small molecule luteolin inhibits N-acetyl-alpha-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. J. Biol. Chem., 292:21304-21319, 2017 Cited by PubMed: 29061849DOI: 10.1074/jbc.M117.814202 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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