5NDF
Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Polypeptide N-acetylgalactosaminyltransferase 2 | polymer | 571 | 64824.7 | 6 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) | Homo sapiens (Human) | Polypeptide GalNAc transferase 2,pp-GaNTase 2,Protein-UDP acetylgalactosaminyltransferase 2,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 |
| 2 | CA, G, O, S, V... (F, A, B, C, D...) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 3 | AA, DA, H, P, T... (E, F, A, B, C...) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 6 | Chemie (UDP) | |||
| 4 | BA, EA, I, J, K... (E, F, A, B, C...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | N, R, Y (A, B, D) | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | non-polymer | 286.2 | 3 | Chemie (LU2) | |||
| 6 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 848 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 571 (UniProt: Q10471)
| PDB | External Database | Details |
|---|---|---|
| Asp 516 | Asn 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 388948.2 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 4234.0 | |
| All* | Total formula weight | 393182.2 |
