5NDF
Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Polypeptide N-acetylgalactosaminyltransferase 2 | polymer | 571 | 64824.7 | 6 | UniProt (Q10471) Pfam (PF00535) Pfam (PF00652) | Homo sapiens (Human) | Polypeptide GalNAc transferase 2,pp-GaNTase 2,Protein-UDP acetylgalactosaminyltransferase 2,UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 |
| 2 | CA, G, O, S, V... (F, A, B, C, D...) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) PubChem (27854) | |||
| 3 | AA, DA, H, P, T... (E, F, A, B, C...) | URIDINE-5'-DIPHOSPHATE | non-polymer | 404.2 | 6 | Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (60098857) PubChem (57448939) PubChem (3084486) PubChem (91746160) PubChem (6101632) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (93088131) PubChem (93630083) PubChem (6604175) PubChem (11811538) PubChem (12049241) | |||
| 4 | BA, EA, I, J, K... (E, F, A, B, C...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | N, R, Y (A, B, D) | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | non-polymer | 286.2 | 3 | Chemie (LU2) PubChem (5280445) | |||
| 6 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 848 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 571 (UniProt: Q10471)
| PDB | External Database | Details |
|---|---|---|
| Asp 516 | Asn 516 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 388948.2 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 4234.0 | |
| All* | Total formula weight | 393182.2 |
