5NDF

Small-molecule inhibition of ppGalNAc-Ts selectively reduces mucin-type O-glycosylation

Summary for 5NDF

• Entry DOI: 10.2210/pdb5ndf/pdb
• Descriptor: Polypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: galnac-t2 inhibition flavonoids mucin-type o-glycosylation alzheimer disease, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein : Q10471
• Total number of polymer chains: 6
• Total formula weight: 393182.20

Authors

Hurtado-Guerrero, R.,De las Rivas, M. (deposition date: 2017-03-08, release date: 2017-11-01, Last modification date: 2024-01-17)

• Primary citation: Liu, F.,Xu, K.,Xu, Z.,de Las Rivas, M.,Wang, C.,Li, X.,Lu, J.,Zhou, Y.,Delso, I.,Merino, P.,Hurtado-Guerrero, R.,Zhang, Y.,Wu, F.; The small molecule luteolin inhibits N-acetyl-alpha-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein.; J. Biol. Chem., 292:21304-21319, 2017; PubMed: 29061849; DOI: 10.1074/jbc.M117.814202

Experimental method

X-RAY DIFFRACTION (2.3 Å)