Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043571 | biological_process | maintenance of CRISPR repeat elements |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 2083 |
| Chain | Residue |
| A | A65 |
| A | U66 |
| A | HOH3252 |
| A | HOH3278 |
| A | HOH3279 |
| B | THR1102 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 2084 |
| Chain | Residue |
| A | HOH3158 |
| A | HOH3299 |
| A | G21 |
| A | HOH3006 |
| A | HOH3156 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 2365 |
| Chain | Residue |
| A | A68 |
| A | HOH3280 |
| A | HOH3283 |
| B | GLN1350 |
| B | HOH3588 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 2366 |
| Chain | Residue |
| B | GLU584 |
| B | ARG586 |
| B | ASN588 |
| B | HOH3356 |
| B | HOH3357 |
| E | HOH3039 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1083 |
| Chain | Residue |
| A | HOH3102 |
| A | HOH3104 |
| A | HOH3112 |
| A | HOH3299 |
| A | HOH3300 |
| A | HOH3301 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1084 |
| Chain | Residue |
| A | U50 |
| A | HOH3183 |
| A | HOH3184 |
| A | HOH3185 |
| A | HOH3187 |
| A | HOH3209 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 2367 |
| Chain | Residue |
| B | LEU623 |
| B | THR624 |
| B | PHE626 |
| B | TYR656 |
| B | HOH3386 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 2368 |
| Chain | Residue |
| A | HOH3107 |
| B | GLY361 |
| B | TYR362 |
| B | GLY365 |
| B | ALA367 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 2369 |
| Chain | Residue |
| B | ILE226 |
| B | LEU229 |
| B | GLU232 |
| B | HOH3021 |
| B | HOH3022 |
| B | HOH3174 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 2370 |
| Chain | Residue |
| B | GLU108 |
| B | LYS111 |
| B | HOH3108 |
| B | HOH3109 |
| B | HOH3111 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 2371 |
| Chain | Residue |
| B | ASP576 |
| B | SER577 |
| B | ALA640 |
| B | PHE643 |
| B | HOH3396 |
| B | HOH3399 |
| B | HOH3401 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 1085 |
| Chain | Residue |
| A | U12 |
| A | G13 |
| A | HOH3055 |
| A | HOH3060 |
| A | HOH3061 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 2372 |
| Chain | Residue |
| A | HOH3254 |
| A | HOH3255 |
| A | HOH3263 |
| B | GLU57 |
| B | HOH3003 |
| B | HOH3053 |
| B | HOH3593 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 2373 |
| Chain | Residue |
| A | U22 |
| A | HOH3109 |
| A | HOH3114 |
| B | ASP364 |
| B | GLY365 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K D 1013 |
| Chain | Residue |
| D | DT5 |
| D | HOH3002 |
| D | HOH3003 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 17 |
| Details | Region: {"description":"ARM","evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 47 |
| Details | Region: {"description":"RuvC-II","evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000303"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Motif: {"description":"PAM substrate-binding","evidences":[{"source":"PubMed","id":"25079318","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For RuvC-like nuclease domain","evidences":[{"source":"PubMed","id":"24529477","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor for HNH nuclease domain","evidences":[{"source":"PubMed","id":"24529477","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24505130","evidenceCode":"ECO:0000269"}]} |
