5FIR
Crystal structure of C. elegans XRN2 in complex with the XRN2-binding domain of PAXT-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004527 | molecular_function | exonuclease activity |
| C | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0004527 | molecular_function | exonuclease activity |
| E | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| G | 0003676 | molecular_function | nucleic acid binding |
| G | 0004527 | molecular_function | exonuclease activity |
| G | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| I | 0003676 | molecular_function | nucleic acid binding |
| I | 0004527 | molecular_function | exonuclease activity |
| I | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| I | 0005634 | cellular_component | nucleus |
| I | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| K | 0003676 | molecular_function | nucleic acid binding |
| K | 0004527 | molecular_function | exonuclease activity |
| K | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| K | 0005634 | cellular_component | nucleus |
| K | 0006139 | biological_process | nucleobase-containing compound metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1788 |
| Chain | Residue |
| E | ASP103 |
| E | LYS110 |
| E | GLN114 |
| E | ARG117 |
| E | ARG118 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1788 |
| Chain | Residue |
| C | ARG118 |
| C | ASN56 |
| C | LYS110 |
| C | GLN114 |
| C | ARG117 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1788 |
| Chain | Residue |
| A | ASN56 |
| A | LYS110 |
| A | GLN114 |
| A | ARG117 |
| A | ARG118 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1789 |
| Chain | Residue |
| A | GLN723 |
| E | ARG304 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 I 1788 |
| Chain | Residue |
| I | LYS110 |
| I | GLN114 |
| I | ARG117 |
| I | ARG118 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1788 |
| Chain | Residue |
| G | LYS110 |
| G | GLN114 |
| G | ARG117 |
| G | ARG118 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 K 1788 |
| Chain | Residue |
| K | LYS110 |
| K | GLN114 |
| K | ARG117 |
| K | ARG118 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1790 |
| Chain | Residue |
| E | THR696 |
| E | ALA697 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1791 |
| Chain | Residue |
| E | ARG329 |
| E | LYS379 |
| E | ARG387 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1789 |
| Chain | Residue |
| C | ARG329 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1789 |
| Chain | Residue |
| A | ARG329 |
| A | LYS379 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1789 |
| Chain | Residue |
| G | PRO347 |
| G | HIS348 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1790 |
| Chain | Residue |
| A | THR696 |
| A | ALA697 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1790 |
| Chain | Residue |
| G | ARG68 |
| G | LYS298 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 1792 |
| Chain | Residue |
| E | MSE373 |
| E | ARG387 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1791 |
| Chain | Residue |
| A | LYS642 |
| A | GLN646 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 I 1789 |
| Chain | Residue |
| I | ARG304 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 1791 |
| Chain | Residue |
| G | ARG329 |
| G | LYS379 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 K 1789 |
| Chain | Residue |
| K | ARG329 |
| K | TYR376 |
| K | LYS379 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 K 1790 |
| Chain | Residue |
| A | GLN724 |
| K | ASN320 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1792 |
| Chain | Residue |
| A | ARG304 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 K 1791 |
| Chain | Residue |
| K | PRO347 |
| K | HIS348 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1793 |
| Chain | Residue |
| A | GLU47 |
| C | ARG714 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1794 |
| Chain | Residue |
| A | ARG548 |
| A | GLY554 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1795 |
| Chain | Residue |
| A | PRO347 |
| A | HIS348 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1790 |
| Chain | Residue |
| C | LEU346 |
| C | PRO347 |
| C | HIS348 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 1790 |
| Chain | Residue |
| I | ARG329 |
| I | GLY375 |
| I | TYR376 |
| I | LYS379 |
| I | ARG387 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 102 |
| Details | ZN_FING: CCHC-type |
| Chain | Residue | Details |
| A | ASN299-LEU316 | |
| C | ASN299-LEU316 | |
| E | ASN299-LEU316 | |
| G | ASN299-LEU316 | |
| I | ASN299-LEU316 | |
| K | ASN299-LEU316 |
