5FC6
Murine SMPDL3A in complex with ADP analog AMPCP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006685 | biological_process | sphingomyelin catabolic process |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
A | 0008150 | biological_process | biological_process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009143 | biological_process | nucleoside triphosphate catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016887 | molecular_function | ATP hydrolysis activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26792860 |
Chain | Residue | Details |
A | ASP42 | |
A | HIS44 | |
A | ASP107 | |
A | ASN148 | |
A | HIS249 | |
A | HIS290 | |
A | HIS292 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26792860 |
Chain | Residue | Details |
A | HIS111 | |
A | HIS149 | |
A | TYR257 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26792860 |
Chain | Residue | Details |
A | ASN66 | |
A | ASN128 | |
A | ASN235 | |
A | ASN353 | |
A | ASN364 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN219 |