5F4E
Crystal structure of the human sperm Izumo1 and egg Juno complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0007342 | biological_process | fusion of sperm to egg plasma membrane involved in single fertilization |
| A | 0016020 | cellular_component | membrane |
| A | 0035036 | biological_process | sperm-egg recognition |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005542 | molecular_function | folic acid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007155 | biological_process | cell adhesion |
| B | 0007338 | biological_process | single fertilization |
| B | 0007342 | biological_process | fusion of sperm to egg plasma membrane involved in single fertilization |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0035036 | biological_process | sperm-egg recognition |
| B | 0038023 | molecular_function | signaling receptor activity |
| B | 0098552 | cellular_component | side of membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Domain: {"description":"Ig-like C2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Region: {"description":"Important for interaction with IZUMO1R","evidences":[{"source":"PubMed","id":"27309818","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Region: {"description":"Important for interaction with IZUMO1","evidences":[{"source":"PubMed","id":"27309808","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27309818","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
