5ERG
Crystal structure of the two-subunit tRNA m1A58 methyltransferase TRM6-TRM61 in complex with SAM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008033 | biological_process | tRNA processing |
| A | 0030488 | biological_process | tRNA methylation |
| A | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| A | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0030488 | biological_process | tRNA methylation |
| B | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| B | 0032259 | biological_process | methylation |
| B | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue SAM B 401 |
| Chain | Residue |
| B | GLN92 |
| B | GLU139 |
| B | PHE140 |
| B | ARG144 |
| B | ARG167 |
| B | ASP168 |
| B | VAL169 |
| B | CYS170 |
| B | ASP203 |
| B | LEU204 |
| B | HOH506 |
| B | VAL94 |
| B | GLY118 |
| B | THR119 |
| B | GLY120 |
| B | SER121 |
| B | GLY122 |
| B | SER123 |
| B | PHE124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27582183, ECO:0000312|PDB:5ERG |
| Chain | Residue | Details |
| B | VAL94 | |
| B | SER121 | |
| B | GLU139 | |
| B | ASP168 | |
| B | ASP203 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q96FX7 |
| Chain | Residue | Details |
| B | ARG144 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| B | SER302 |
